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ANU Toxo Lab @ANUToxoLab
Joined February 2020
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Come join our fabulous department to undertake a PhD!
ANU Division of Biomedical Science & Biochemistry@ANU_RSB_BSB
19 Dec 2023
Want to undertake a cutting-edge PhD in molecular sciences? Are you a high-achieving student (Australian or New Zealand citizen or PR)? Contact one of our award-winning research Group Leaders to express your interest: rb.gy/uhtyfc / Info: rb.gy/g9jjgf
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A new paper from our group investigating the essential role of an iron-sulfur (Fe-S) protein in the cytochrome c oxidase complex (Complex IV) of the Toxoplasma mitochondrial electron transport chain! 1/9 journals.plos.org/plospathog…

An essential role for an Fe-S cluster protein in the cytochrome c oxidase complex of Toxoplasma...

Author summary Complex IV is a canonical component of the electron transport chain (ETC) of eukaryotic mitochondria. Recent evidence indicates that considerable diversity exists in the protein...

journals.plos.org
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What might the role of the Fe-S clusters on Complex IV be? We don’t know for certain. The lability of ApiCox13 when lacking its Fe-S clusters could mean that ApiCox13 regulates Complex IV and ETC function in response to iron availability or levels of reactive oxygen species. 8/9
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A super enjoyable project led by the amazing Jenni Hayward and Rachel Leonard. Jenni’s first senior author publication and Rachel’s first first author one (not bad for an undergrad project!). Very grateful also for Feng and Yuan’s contributions! 9/9
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Check out this Research Officer position in our department with Alex Maier's group!
ANU Division of Biomedical Science & Biochemistry@ANU_RSB_BSB
21 Mar 2023
Exciting opportunity for a Research Officer to join the team at BSB! Contribute to the development of a novel drug delivery system to target parasitic infections and related diseases affecting millions globally. bit.ly/3Ttgy3V#researchjobs #parasiticinfections #drugdelivery
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A really cool new manuscript from Adele Lehane’s lab @ANU_RSB_BSB , demonstrating that a single amino acid change in the sodium pump of Plasmodium parasites confers >1000-fold resistance to a leading new anti-malarial drug called cipargamin. 1/8 nature.com/articles/s41467-0…

A G358S mutation in the Plasmodium falciparum Na pump PfATP4 confers clinically-relevant resista...

Nature Communications - In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in...

nature.com
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As cipargamin and other PfATP4 inhibitors make it to the field, it will be important to monitor for the G358S mutation as a marker for emerging resistance. 7/8
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Great work by Deyun, Victor and James, and many collaborators including @CorryLab , @fidocklab , @PhotiniSinnis17 and Marcus Lee. Glad we could contribute on the Toxo side of things! 8/8
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Parasitology through art - cool stuff from the creative students on Alex Maier's 3rd year undergrad course!
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