How does your immune system tell pathogenic RNA from your own, even though theyβre made of the same stuff? Our latest paper with
@GantierLab
shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. π§¬π¬β nature.com/articles/s41590-0β¦
Beginning 2026 with a flipping good paperπOSCA/TMEM63 proteins do double duty: theyβre ion channels andmechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. π@yiechanglin@Charles_D_Coxdoi.org/10.1038/s41467-026-6β¦
2 yrs ago @yiechanglin sent me this of lipid scrambling by OSCA1.2. Now we show itβs common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @Charles_D_Cox
&Zhang lab. tiny.cc/tmem63
πWe are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipidsπ
Join us at @ourANU with amazing collaborators and great working conditions!
Apply: tiny.cc/corry. Us: karri.anu.edu.au
πWe are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipidsπ
Join us at @ourANU with amazing collaborators and great working conditions!
Apply: tiny.cc/corry. Us: karri.anu.edu.au
Excited to share @john_d_tanner's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2)
tiny.cc/PfCRT
1/ In my final project as part of the @CorryLab, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations..
biorxiv.org/content/10.1101/β¦
Thrilled to share our latest preprint from @yiechanglin & @ciara__wallis showing AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states π)
tiny.cc/oligomers
Big congratulations to @Riottowow for winning an Anders Early Career Award at @LorneProteins #lorneproteins2025 ! Presenting his work on the lipid lined pore of the OSCA mechanosensitive channel.
Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 Pi selection/permeation by a channel-like knock-kiss-kick mechanism
π» @ciara__wallis@Riottowowtiny.cc/xpr1
Excited to start the year with this lovely paper with @whoiselainetao showing that drugs that inhibit sodium channels bind in a range of sites within the pore cavity rather having a single distinct pose.
@JGenPhysiol@scienceANU@NCInews
Tao and Corry @CorryLab@ANU_RSB_BSB investigate the binding of sodium channel inhibitors to the Naα΅₯1.5 pore using simulations, revealing promiscuous, polyspecific binding at the fenestrations and central cavity. hubs.la/Q031spy70
Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on sodiumchannelseminars.org. Mark your calendar and join the discussions!
We've just opened expressions of interest to EIGHT PhD scholarships in plant biosecurity! Each come with integrated placements in government or industry, awesome travel and professional development. #PhD#PhDposition#biosecurityplantbiosecuritycentre.edu.aβ¦