@APHage_ profile picture
Alexander Hynes @APHage_
Joined July 2019
  • Tweets 556
  • Following 486
  • Followers 964
49 Photos and videos
Pinned Tweet
Alexander Hynes@APHage_
25 Feb 2020
As I polish up my resubmission, I also reflect on the 'mistakes' of my initial CIHR project grant. If a limerick can ever be a mistake...
15
Two surprises hiding in our latest! (1) How broadly effective Piperacillin is at synergizing with temperate phages. Maybe a reason PTZ is so effective? (2) Our inability to correlate any likely predictors of tPAS to actual synergy. journals.asm.org/doi/10.1128…

Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host...

The recent discovery that otherwise therapeutically unusable temperate phages can potentiate the activity of antibiotics, resulting in a potent synergy, has only been tested in E. coli, and with a...

journals.asm.org
12
784
"Now that you've reviewed for us for free, would you also complete this short survey on the review process that will only take 12-15 minutes?"
1
3
511
Dr. @rabiafatima_ has "tPASsed". Too many feels. Thank you @implosian - sorry you couldn't make it for the presentation of the warhammer. I do get asked if I fear the graduates will use them against me... no! Not in public, anyway - they're all far too smart to get caught.
3
1
27
2,082
Another double-podium finish for the Hynes Lab! The costume is a bit of an in joke/homage to @Yingfu8888, while the pumpkins... well, I'd say they speak for themselves, although having "Bye Bye Bye" playing out of the speaker added a nice touch.
8
573
The night before NoR. Last week at @CSM_SCM2024 I met many fantastic researchers in this competition, in the same panel. And for 85% of us, tomorrow is going to suck. What's the better way forward?
6
1,486
A picture is worth 1536 plaque assays. While we used a robot, we also tried a dirt-cheap 3D-printed alternative which works wonders at 384-density. I really believe this pre-print has the potentially to be the largest impact I will make on my field. biorxiv.org/content/10.1101/…
5
50
195
29,784
I'd love for some of you who have done massive screens (@baym, @AHarms485, for example) to give this a look. It's a really simple concept, and works *way* better than I thought it would. I never expected we could see plaques at this resolution.
4
1
17
2,156
Alexander Hynes retweeted
mBio@mbiojournal
22 May 2024
If you've induced phages, you may have wondered if you can do the opposite: block entry into lysogeny. You can, using protein synthesis inhibitors! This yields a potent synergy, functionally turning a temperate phage into a virulent one. @APHage_ #mBio journals.asm.org/doi/10.1128…
4
26
3,113
If you've induced phages, you may have wondered if you can do the 'opposite' - block entry into lysogeny. You can, using protein synthesis inhibitors! Better still, this yields a potent synergy, functionally turning a temperate phage into a virulent one. journals.asm.org/doi/10.1128…
28
93
10,192
That's one impressive host range, and not even in the top 5 coolest things about this story.
Siân Owen@implosian
13 Apr 2024
Replying to @implosian
For example, the prototypical IncP plasmid-dependent phage PRD1 has a very generalist host range, and can infect most g-proteobacteria carrying an IncP plasmid. PRDcerulean is 95% identical to PRD1 but has a very narrow host range, mostly restricted to Pseudomonas (4/ )
1
8
28
5,412
Et de deux! @DNADoubleFelix presenting the spoils of his PhD - Warhammer, Phage-Planters, and DNA. Oh, and a Thesis, I suppose. A masterful defence, a wonderful external @jwmodell... and there goes the last of the lab's starting cohort. *sniff*.
3
2
34
2,193
Ladies, Gentlemen - I present to you the first PhD out of the Hynes Lab - congratulations Dr. Al-Anany!
18
14
527
44,517
Alexander Hynes retweeted
Pramalkumar Patel@pramalpatel
22 Feb 2024
I am thrilled to share our work on a novel prophage-encoded phage defence from @theMaxwellLab: Anti-phage defence through inhibition of virion assembly nature.com/articles/s41467-0…

Anti-phage defence through inhibition of virion assembly

Nature Communications - Bacteria have evolved various defence mechanisms to protect themselves against viral infection. Here, Patel et al. identify a type of antiviral defence that blocks virion...

nature.com
6
47
127
50,993
Oh dear. it looks exactly like what I would scribble if I were asked to draw a JAK-STAT pathway in an exam today. Uncanny.
Jesse Gilmer@ParallelFibers
15 Feb 2024
Replying to @ravenscimaven @FrontiersIn
This is not how Resprouization of íe regisors works...
7
1,344
Alexander Hynes retweeted
Canadian Running@CanadianRunning
11 Feb 2024
Marathon world record holder Kelvin Kiptum, dead at 24: runningmagazine.ca/the-scene…
Photo: Kevin Morris

ALT Photo: Kevin Morris

10
21
31
26,940
Alexander Hynes retweeted
NSERC / CRSNG
@NSERC_CRSNG
1 Nov 2023
🏆 Karen Maxwell @UofT wins an Arthur B. McDonald Fellowship in recognition of world-leading contributions to bacteriophage research and its applications. ▶️ tinyurl.com/32xv3smx
IMAGE: Portrait of Karen Maxwell (University of Toronto) standing in a lab, with a logo in white for NSERC PRIZES 2023, on the left. @theMaxwellLab

ALT IMAGE: Portrait of Karen Maxwell (University of Toronto) standing in a lab, with a logo in white for NSERC PRIZES 2023, on the left. @theMaxwellLab

4
11
66
8,841
The Hynes Lab Halloween! Even with a song and routine, we couldn't overthrough the reigning champion Li Lab in the costume contest, although we did claim victory in the Pumpkins!
26
1,121
Alexander Hynes retweeted
Arjun Raj
@arjunrajlab
28 Sep 2023
I don’t get this whole “correlation is not causation” thing. Every time I see a correlation, it seems to be causative.
23
5
95
47,510
When my 4-y old packs his lunch, it's by taking the easiest path to meeting our criteria for 'lunch'. With no consideration for the food he actually wants to eat that next day. There's a lesson there...
2
821
Load more