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Agard Lab retweeted
2 Aug 2023
Smriti Sangwan (@smriti_sangwan) from the @agardlab & Peter Walter labs @UCSF is about to present her research - molecular mechanisms of translational regulation.
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🎉🎉🎉
15 May 2023
New featured image on our homepage!
nature.com/ncomms/
Related to this article:
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice
nature.com/articles/s41467-0…
@ENieweglowska @AgardLab @UCSF
#phagenucleus #jumbophage #phage #structuralbiology
ALT A lattice of protein tetramers
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Congratulations to Maru & team on the lab’s latest pub!
PP5 requires the molecular chaperone Hsp90 to dephosphorylate CRaf kinase and Hsp90 cochaperone Cdc37. Here, authors show how Hsp90 acts as a platform to allow for targeted dephosphorylation by PP5.
nature.com/articles/s41467-0…
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Check out the latest preprint from @andreafossati9 and @MozumdarDeepto on using SEC-MS to identify protein:protein interactions during jumbo phage infections! Congrats, team!
#phage #jumbophage #secms
24 Feb 2023
New preprint alert!
Here we show how SEC-MS is a powerful tool for host pathogen interactions profiling. We applied it to Jumbophages, which are large bacterial viruses (>300 genes) holding great potential as antibiotics.
What did we find? 1\n
biorxiv.org/content/10.1101/…
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Please check out our latest publication from grad student @ENieweglowska on the self-assembly of the phiPA3 phage nucleus! Congrats to the whole team! @MmendezMoran @minkbaek @UWproteindesign @yifan_ucsf @joeBondyDenomy
22 Feb 2023
Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵
#phage #jumbophage #cryoem
nature.com/articles/s41467-0…
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Check out our latest preprint! #CryoEM structures of immunophilins, FKBP51 and FKBP52, in complex with Hsp90 and the glucocorticoid receptor, demonstrating the FKBP co-chaperones directly bind an Hsp90 client to regulate client activity. From recent grad @ChariMN w/ Jill Johnson
12 Jan 2023
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor biorxiv.org/cgi/content/shor… #bioRxiv
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Agard Lab retweeted
22 Oct 2022
@AgardLab shared amazing data (published/unpublished) on Hsp90 chaperone complexes. @Hsp90Machine
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High resolution cellular cryoET!
29 Sep 2022
We optmized in situ cryoET to achieve 6 A reconstructions of mouse sperm doublets! The unique tertiary structures allow de novo protein identification of novel sperm proteins by computationally searching in the AlphaFold2 library of entire mouse proteome! biorxiv.org/content/10.1101/…
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Agard Lab retweeted
19 Sep 2022
A family of novel immune systems targets early infection of nucleus-forming jumbo phages biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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this just in --- our FTD CWOW website is LIVE! cwow.ucsf.edu/ Time to spread the news! Great work from our team @Karen_Shuster, @aimee_kao @YokoyamaLabUCSF @karchlab @AgardLab @metadsr_ @tauCWOW #ftdcwow
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We’re excited to announce that David Agard, Bridget Carragher Clint Potter have joined our new @ChanZuckerberg Imaging Institute to bring together scientists and engineers to develop new cryoelectron microscopy imaging hardware and software
🧵czi.co/ImagingInstitute
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Congratulations, @MmendezMoran! #phdcandidate
31 May 2022
I’ve passed my qualifying exam—a huge milestone on my way to a PhD!
So lucky to have amazing mentors and lab mates doing incredible science and throwing even more incredible @AgardLab parties!
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Check out our latest pre-print from postdoc Zhen Chen @ZhenChentccz on mammalian sperm axonemes revealed by in situ cryoET!
16 May 2022
Our preprint on asymmetric axonemes of mammalian sperm revealed by FIB-SEM/cryoET: biorxiv.org/content/10.1101/…
Thanks for the support from the Vale lab and Agard lab! This work would not be possible without my amazing collaborators from the Lishko lab and Janelia Research Campus.
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Explore emerging research and network with peers at our Protein Folding in the Cell Conference. Organized by Manajit Hayer-Hartl @MPI_Biochem and Jeffery Kelly @scrippsresearch. Don't miss keynote speaker David A. Agard @AgardLab bit.ly/3NGsdc3 #PFCSRC22
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Agard Lab retweeted
7 Apr 2022
The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice biorxiv.org/cgi/content/shor… #bioRxiv
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Check out our latest preprint showing that the major protein enclosing the Phage Nucleus (PhuN) forms a tetrameric lattice with C2 symmetry. The symmetry establishes 4 unique interfaces, two large enough to act as channels for small molecules, RNA, or even unfolded proteins.
7 Apr 2022
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice!
biorxiv.org/content/10.1101/…
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Congratulations to all of our authors! @ENieweglowska, Axel Brilot, @MmendezMoran, @minkbaek, Junrui Li, Claire Kokontis, David Baker (@UWproteindesign), @yifan_ucsf, and @joeBondyDenomy
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We've got that Friday feeling! Earlier this week, #tau2022 was a success! Our #ftdcwow team was in attendance and thrilled to discuss about Tau. @karchlab @YokoyamaLabUCSF @AimeeKaoLab @AgardLab @metadsr_ alz.org/tau/overview.asp
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Agard Lab retweeted
18 Feb 2022
#CryoeM #CryoET has enormous potential allow researchers to study #structuralbiology in situ but low throughput limits applications. This new publication from Shawn Zheng of @AgardLab @UCSF addresses that problem and offers on-the-fly processing!
biorxiv.org/content/10.1101/…
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