Scientist at @altos_labs // PhD @AgardLab (UCSF) studying protein folding using #cryoEM // UT Austin ‘16
Joined April 2012
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Very happy to have my grad school research published! This was a really fun project driven by a great collab with @WangyrRay. How do Hsp70 and Hsp90 cooperate to unfold a client protein? How does Hsp90 refold and reactivate a client protein? How do co-chaperones help? See below!
Very excited to announce our two new papers! #CryoEM structures demonstrate how Hsp70 and Hsp90 cooperate to regulate the folding and function of a model client, the glucocorticoid receptor. First authors @WangyrRay and @ChariMN
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
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Chari N retweeted
22 Feb 2023
Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵
#phage #jumbophage #cryoem
nature.com/articles/s41467-0…
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Chari N retweeted
18 Feb 2023
The jumbo-phage phi-PA3 encloses its replicating genome in a *beautiful* symmetrically flexible lattice!
Congratulations to an amazing mentor and friend @ENieweglowska
nature.com/articles/s41467-0…
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Congrats Eliza!!!
7 Apr 2022
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice!
biorxiv.org/content/10.1101/…
Chari N retweeted
5 Nov 2020
Cryo-EM amazingness!
4 Nov 2020
This week on the Nature cover: Atoms in focus. Single-particle cyro-EM powers protein imaging at atomic resolution. Browse the issue here: go.nature.com/3mRQH3X
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Our preprint is out! How the glucocorticoid receptor (GR) is reactivated by the molecular chaperone Hsp90 and the co-chaperone p23, revealed by cryo-EM
14 Sep 2020
GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex biorxiv.org/cgi/content/shor… #bioRxiv
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Chari N retweeted
6 Feb 2017
In response to threats to our public lands, @TheNorthFace and @Patagonia are committing an additional $100K annually to @ConservationAll.
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