Our lab develops quantitative methods to design therapies for tuberculosis and to understand complex cell behaviors.
Joined November 2013
- Tweets 531
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16 Photos and videos
15 Nov 2024
Tap tap…is the🎙️ still on? This work has been in the works for a long time! We studied the growth behaviors and cell cycle timing of individual TB bacilli and ended up with a series of surprises and a lot of new questions. 1/5 nature.com/articles/s41564-0…
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15 Nov 2024
Finally, it is thought that a broad range of cell types grow exponentially at the single-cell level, but we find that Mtb grow linearly, implying that we need to study what processes Mtb use to control growth as it is fundamentally different from other studied cell types. 4/5
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15 Nov 2024
Together this project really underscores the importance of studying fundamentals of cell biology in non-model organisms. This was a really challenging project made possible by an incredible collaboration with Eun Seon Chung, @Ariel_4321, and @KarPrathitha. 5/5 #tuberculosis
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Bree Aldridge retweeted
1 Aug 2024
.@trevercsmith of @TuftsMedSchool has been named winner of the #BAL 2024 Emerging Leader Award. Dr. Smith will receive $150K for his pioneering research on combination therapies for persistent #Lymedisease. His work aims to create a first-of-its-kind drug interaction compendium to better target persistent Borrelia burgdorferi (Bb) infections. This could lead to more effective treatments, offering new hope for those w/ persistent #Lyme.
Read the full release here: bit.ly/4d3Slu1
#Lymediseaseresearch #Lymetherapeutics
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5 Jan 2024
This is an amazing program! Please RT! Would be happy to discuss opportunities in my group or at Tufts for IRACDA fellows!
20 Nov 2023
WE ARE HIRING! Currently recruiting for our next cycle beginning 9/1/24 for postdoctoral scholar training positions! Applications due 2/1/24! gsbs.tufts.edu/academics/tuf… #sciencejobs #postdoc #science #research #career #hiring #jobs @TuftsUniversity @TuftsGSBS @TuftsMedSchool
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Bree Aldridge retweeted
6 Oct 2023
Happy to celebrate the inauguration of new Tufts President Sunil Kumar and share the platform with TUSM Dean @hboucher3 GSBS Professor @AldridgeLab Tufts A&S Graduate Dean Barbara Brizuela @TuftsUniversity @TuftsMedicalCtr @TuftsMedSchool @TuftsGSBS
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7 Oct 2023
Had a great celebratory week welcoming Tufts' 14th president, Sunil Kumar! #TuftsLightingTheWay
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23 May 2023
Excited to share our new preprint describing the single-cell growth behaviors of pathogenic Mycobacterium #tuberculosis with Eun Seon Chung @KarPrathitha @Ariel_432 and Maliwan Kamkaew 1/5
18 May 2023
Mycobacterium tuberculosis grows linearly at the single-cell level with larger variability than model organisms biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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23 May 2023
As more types of bacteria are used for fundamental studies of cell biology, I think we will discover that there is far more diversity in the interworking of cells than previously believed 5/5
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23 May 2023
We have yet to understand why or how Mtb grow linearly and how they systematically create so much heterogeneity, but it is clear that to understand the single-cell characteristics of Mtb, we have to continue to study the pathogen itself 4/5
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23 May 2023
Most cell types have an exponential growth mode at single-cell level, but we discovered that Mtb growth is linear. We find that Mtb’s (slow) growth has a unique linear growth mode that is overlayed on more cell-to-cell variation than in model organisms 3/5
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23 May 2023
We report the characteristics of Mtb growth & cell cycle timing for the first time. We find a LOT of variation in growth speed, cell size, and cell cycle timing. But unlike in M. smegmatis, there is not a deterministic relationship between growth pole age & growth behaviors 2/5
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7 Oct 2022
We took the afternoon off for a goat hike and ice cream! It was a blast 🐐🍁🍃🍦. I am very thankful to work with this incredible team of creative and kind people!
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5 Oct 2022
Congratulations to @CarolynBertozzi! Thanks for making tools to help us understand #tuberculosis and also for training amazing colleagues :) @siegristpalmore @jcslab @MireilleKamariz
5 Oct 2022
Carolyn Bertozzi – awarded the 2022 #NobelPrize in Chemistry – has taken click chemistry to a new dimension and started utilising it in living organisms. Her bioorthogonal reactions take place without disrupting the normal chemistry of the cell.
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5 Oct 2022
Oh and also...your hometown is SO EXCITED too! <3 We will take a walk by LHS in your honor today :) @CarolynBertozzi
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23 Sep 2022
Thrilled (and flattered) to read this preview by one of my scientific heroes and leader in the field of drug #combinationtherapy @ac_palmer @SarahCooperUNC
23 Sep 2022
Online now: Predicting in vivo activity of combination therapies from in vitro drug pairs in diverse environments dlvr.it/SYsQsl
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