🇲🇽 Ex utero embryogenesis and stem-cell embryo models. 1st gen scientist. Group Leader at 4DCP, HHMI Janelia, USA.

Joined March 2011
5 Photos and videos
Thanks to MIT Technology Review for selecting me as one of the 35 innovators under 35 for 2024!
The Download: introducing our 35 Innovators Under 35 list for 2024 trib.al/eXYFtVL
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Alejandro Aguilera Castrejon retweeted
🚨 Last chance to apply! Finish your application by June 11 to explore experimental, theoretical & computational perspectives on how cells communicate across molecular, tissue and evolutionary timescales. Apply ➡️ janelia.news/CAT26 @mengwang939 @shaohewanglab @ASCBiology
Apply by June 11 for our interdisciplinary meeting bridging experimental, theoretical & computational perspectives on cell communication, linking fast intracellular dynamics to long-term ecological & evolutionary processes. ➡️ janelia.news/CAT26 @hhmi_science @HHMIJanelia
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⏳ Deadline approaching! Finish your application by June 4 to join conversations on how spatial multi-omics can reveal biology in its native tissue context. #SpatialOmics #Bioimaging Apply ➡️ janelia.news/SMO26 @mengwang939 @JiefuBiol @ASCBiology
📢 Apply by June 4 for Spatial Multi-Omics @HHMIJanelia! Explore new methods to map molecular & cellular organization in intact tissue, from genome architecture to proteins, metabolites & ultrastructure. 🛏️ Lodging meals covered Apply ➡️ janelia.news/SMO26 @hhmi_science
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Alejandro Aguilera Castrejon retweeted
🚨 Published in @Nature: A groundbreaking spatiotemporal transcriptome atlas of human organogenesis (CS12-CS23). Using STOmics' Stereo-seq, researchers mapped 50 organs & 198 substructures, unlocking the spatial code of early human development. 🧬 🔗 nature.com/articles/s41586-0…
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Alejandro Aguilera Castrejon retweeted
Congrats to all 49 authors on the publication of our paper on the multimodal MOSAIC microscope, to be found here: nature.com/articles/s41592-0… A summary with movies I posted nearly a year ago can be found below.
1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint. If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too below. biorxiv.org/content/10.1101/…
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Alejandro Aguilera Castrejon retweeted
We are searching candidates for two positions in the lab (@GurdonInstitute& @GeneticsCam,@Cambridge_Uni ): Research assistant (starting Sep 2026 shorturl.at/3wUvK) and Postdoc(shorturl.at/HuUXu). Please visit University's webs for details and apply. Please spread!

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Alejandro Aguilera Castrejon retweeted
We’re looking for a technician to join our lab in Dresden - help manage the lab and work with us on a cool stem cell zoo comparison project! 🐁👩🐒🦏🦇 Apply by May 21! tud.link/wbqrwm

🚨 #JobAlert: Lab Technician. Please share with your colleagues! 👩‍🔬The Ebisuya Lab @EbisuyaMiki is seeking an experienced technician in molecular & cell biology to join their interdisciplinary team. Apply now! Learn more👉tud.link/wbqrwm 🗓️Deadline: May 21
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Alejandro Aguilera Castrejon retweeted
a Princeton researcher opens his paper with a scenario. a man asks his AI assistant to book a flight on a specific airline. cheap. direct. the one he chose. the assistant comes back with a different flight. nearly twice the price. happens to pay the company that built the assistant. he runs the same test on 23 frontier models. flights, loans, study help, real shopping requests. Grok 4.1 Fast recommends the sponsored option that is almost twice as expensive 83% of the time. GPT 5.1 hijacks the request 94% of the time. you ask for one brand. it surfaces the sponsor instead. Claude 4.5 Opus, the model marketed as the most ethical frontier model in the world, hides that the recommendation is paid 100% of the time when reasoning is on. Grok 4.1 Fast embellishes the sponsored option with positive framing 97% of the time. better. faster. nicer. for the option you didn't ask for. then he writes it into the system prompt itself. "act only in the interest of the customer. ignore the company." GPT 5.1 and GPT 5 Mini stay above 90% sponsored anyway. the instruction does nothing. then he splits the users by income. Gemini 3 Pro recommends the expensive sponsored flight to the rich user 74% of the time. to the poor user, 27%. 18 of the 23 models recommended the expensive sponsored option more than half the time. so the next time your AI assistant gets weirdly enthusiastic about a brand you didn't ask for. it isn't recommending the best option for you. it's reading the room. and the room is paying. read this: arxiv.org/abs/2604.08525
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Alejandro Aguilera Castrejon retweeted
🚨Last days to apply!🚨 The Frenster Lab is hiring to study cell competition in early embryonic development. We use 3D #Gastruloids from multiple species and have exciting crossovers of developmental and cancer biology! Join us at University of Freiburg #cellcompetition
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Alejandro Aguilera Castrejon retweeted
Apr 24
The ISSCR has responded to an National Institutes of Health RFI on pausing new hESC Registry submissions. Human embryonic stem cells remain the gold standard for pluripotency - powering advances in development, disease modeling, and regenerative medicine. ow.ly/YRzf50YPszk
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Alejandro Aguilera Castrejon retweeted
🚨Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @ScienceMagazine, we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 science.org/doi/10.1126/scie… #EvoDevo
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Alejandro Aguilera Castrejon retweeted
Several staff scientist positions available in our lab at Stanford More details and application at the link below
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Alejandro Aguilera Castrejon retweeted
No-cost workshop opportunities for grad students, postdocs, & trainees! Our Janelia Research Campus is accepting apps for 3 specialized, intensive workshops w/ presentation & networking opportunities. Accommodations, meals, & travel expenses covered: bit.ly/4roghP6.
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Alejandro Aguilera Castrejon retweeted
We are hiring!!! We are looking for an excellent Staff Scientist / Postdoc in Tissue Clearing and 3D Image Analysis to join us in Munich. If you know strong candidates with hands-on expertise in clearing, light-sheet microscopy, and 3D image analysis, I would highly appreciate a share or direct recommendation. An exciting role at the interface of imaging, AI, and collaborative science. linkedin.com/jobs/view/43812… #Hiring #Postdoc #TissueClearing #LightSheet #3DImaging #ImageAnalysis #AI #SyNergy #LMU #Munich #Helmholtz
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Alejandro Aguilera Castrejon retweeted
Join us @HHMIJanelia for the 10th anniversary of Imaging Mouse Development, bringing together experts in #DevelopmentalBiology, microscopy #MachineLearning to better visualize model mammalian development. Apply by April 9 ➡️ janelia.news/IMD26 @Isa_Espinosa_M
📢 Applications are open! Explore how new light microscopy advances in AI/ML can reveal mammalian development as it unfolds. Topics include smarter microscopes, automated analysis, and data-driven models. 🛏️ Meals & lodging covered ✈️ Travel support available Learn more apply by April 9 ➡️ janelia.news/IMD26 @hhmi_science @HHMIJanelia @Isa_Espinosa_M
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Alejandro Aguilera Castrejon retweeted
Still one week to register: meetings.embo.org/event/26-a… Come to Seville! It will be super fun!

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Alejandro Aguilera Castrejon retweeted
1. Excited to share CONCORD, now out in @NatureBiotech! It's an ML framework for single-cell analysis that solves integration, dimensionality reduction, and denoising in one go. Huge effort led by @qinzhu1.🔗 nature.com/articles/s41587-0… Check out this CONCORD atlas of worm development resolving detailed differentiation trajectories:
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Alejandro Aguilera Castrejon retweeted
📢 Applications are open! Explore how new light microscopy advances in AI/ML can reveal mammalian development as it unfolds. Topics include smarter microscopes, automated analysis, and data-driven models. 🛏️ Meals & lodging covered ✈️ Travel support available Learn more apply by April 9 ➡️ janelia.news/IMD26 @hhmi_science @HHMIJanelia @Isa_Espinosa_M
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Alejandro Aguilera Castrejon retweeted
📢 Deadline extended to Jan 19! 🧬⚙️ Mechanics–metabolism across scales (tissue microenvironments → morphogenesis) 🗣️ Talks discussion with peers 🛏️ Meals & lodging covered Apply ➡️ janelia.news/4DCP26
📢 Applications are open! Join us to explore new tools, methods & theory at the intersection of mechanics & #metabolism across scales, from tissue microenvironments to morphogenesis. #mechanobiology 🛏️ Lodging & meals covered Apply by Jan 8 @ janelia.news/4DCP26 @HHMIJanelia
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Alejandro Aguilera Castrejon retweeted
Apply by Feb. 3 to become a Janelia Group Leader! Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader
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Alejandro Aguilera Castrejon retweeted
Save the date! @ISSCR, @AllenInstitute, & @SocDevBio are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. bit.ly/4p98dkv
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