Drs @AlexanderPerni & @BankovaLora highlight two @ImmunityCP articles on how #TuftCell #acetylcholine promotes #helminth expulsion from @jakob_moltke’s team @UWMedicine and François Gerbe & Philippe Jay’s team @IGF_Montpellier. @BrighamWomens @harvardmed authors.elsevier.com/a/1jM1D…

An atlas of the nasal mucosa in mice describes three #TuftCell populations, two of which were previously annotated differently and a third which had not yet been defined. @BrighamWomens @BankovaLora scim.ag/5LY

Happy to share a new paper out this week in @SciImmunology, work done together with @BankovaLora and lab at @BWHAllergy. The nasal mucosa sits right at the top of the airstream, a perfect place for specialized sensory cells to sample it. science.org/doi/10.1126/scii…

In 2020, right before shutdown, we (with @haber_lab_hsph) set out to understand the function of the olfactory TRPM5 microvillous cells. Like their relatives, the #TuftCells, they line the airway lumen and detect allergens. But their morphology, receptors and function in directing olfactory responses are quite distinct. @SciImmunology @AlexanderPerni @EvelynAvilesF science.org/doi/10.1126/scii…

TRPM5 microvillous cells in the olfactory neuroepithelium are tuft cells that regulate olfactory stem cell proliferation @BankovaLora @SciImmunology @AlexanderPerni et al science.org/doi/10.1126/scii…

Karlotta Schlösser und Alexander Perniss erhalten Dissertationspreise der Deutschen Lungenstiftung über 6.000 Euro idwf.de/-DGOLAC

From “neuro” to “immune”: Rare neuroendocrine cells in the tracheal mucosa speak a language understood by lymphocytes; learn more in the article by Mahmoud and coworkers in the CTR October issue link.springer.com/article/10…

Kummer, Bufe, Perniss &co: Tracheal chemosensory cells recognize virulence-associated formyl peptides & release acetylcholine to activate mucociliary clearance | Genetic impairment of this pathway in mice leads to susceptibility to infection authors.elsevier.com/a/1av0d…

An #optogenetics model in mice suggests microbial metabolite propionate triggers #TuftCells in the gallbladder to mediate mucus secretion and smooth muscle contractions. fcld.ly/01pawvg