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Waggoner Lab @LabWaggoner
Joined August 2018
  • Tweets 37,068
  • Following 8,028
  • Followers 12,884
12,660 Photos and videos
DDX6 prevents aberrant immunity and drives cancer immunosuppression by limiting editing-mediated I-C pairing in dsRNA @SciImmunology science.org/doi/10.1126/scii…

DDX6 induces immunosuppression in cancer by disrupting structural stability of endogenous double-...

DDX6 prevents aberrant immunity and drives cancer immunosuppression by limiting editing-mediated I-C pairing in dsRNA.

science.org
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Review @sciimmunology @slg1717 Tissue-specific roles and downstream signal transduction mechanisms of IL-17 science.org/doi/10.1126/scii…

The tissue-specific regulation of immunobiology by IL-17 signaling

The tissue-specific roles and downstream signal transduction mechanisms of IL-17 in immunobiology are reviewed.

science.org
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Waggoner Lab retweeted
Taekjip Ha@taekjip
Jun 12
We are thrilled to announce an opening for a tenure-track assistant professor in PCMM, Boston Children's Hospital and Harvard Immunology! Apply by August 2, 2026.
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Placenta metabolic clock: NAD depletion triggers a countdown to birth in mice @ScienceMagazine science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…

The placental metabolic clock

NAD depletion triggers a countdown to birth in mice

science.org
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An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV head and neck cancer science.org/doi/10.1126/scit… @ScienceTM @harvardmed

Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV ...

An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV head and neck cancer.

science.org
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SARS-CoV-2 vaccination and infection differentially shift the memory B cell pool science.org/doi/10.1126/scit… @ScienceTM

SARS-CoV-2 variant booster vaccination and infection alter the breadth of the memory B cell...

SARS-CoV-2 vaccination and infection differentially shift the memory B cell pool.

science.org
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IL-27 potentiates severe fever with thrombocytopenia syndrome by disrupting hematopoiesis and amplifying inflammation science.org/doi/10.1126/scit… @ScienceTM

IL-27–mediated hematopoietic dysregulation exacerbates disease severity in severe fever with...

IL-27 potentiates severe fever with thrombocytopenia syndrome by disrupting hematopoiesis and amplifying inflammation.

science.org
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Remodeling lymph node microenvironment by radiotherapy unlocks local antibody-driven B cell depletion science.org/doi/10.1126/scia… @ScienceAdvances

Lymph node microenvironment remodeling unlocks local antibody-mediated B cell depletion

Remodeling lymph node microenvironment by radiotherapy unlocks local antibody-driven B cell depletion.

science.org
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Ultrasound plus tumor cues safely prime CAR-T cells on site, enabling precise, durable attacks on solid tumors science.org/doi/10.1126/scia… @ScienceAdvances

Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy

Ultrasound plus tumor cues safely prime CAR-T cells on site, enabling precise, durable attacks on solid tumors.

science.org
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E. coli releases vesicles that repair membrane damage and promote survival under antibiotic stress science.org/doi/10.1126/scia… @ScienceAdvances

Bacterial extracellular vesicles promote membrane repair and tolerance to polymyxin B

E. coli releases vesicles that repair membrane damage and promote survival under antibiotic stress.

science.org
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Waggoner Lab retweeted
Casanova Lab@casanova_lab
Jun 11
THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/10.1056/NEJMoa2…

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org
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Waggoner Lab retweeted
Rob Manguso@MangusoLab
Jun 10
Excited to share out latest work, out this week in @NatureGenet . In this study, we using CRISPR screens to explore how sensing inflammatory cytokines exposes new tumor-intrinsic dependencies. @broadinstitute @MGBResearchNews nature.com/articles/s41588-0…

Inflammatory cytokines induce new cancer dependencies

Nature Genetics - Cheruiyot et al. conduct genome-scale in vitro CRISPR loss-of-function screens to map genetic vulnerabilities induced by inflammatory cytokines and identify the...

nature.com
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Waggoner Lab retweeted
Eric Topol
@EricTopol
Jun 10
Not every day you see an odds ratio of 50 (for interleukin-10 autoantibodies and a common HLA allele). ~80% of patients with inflammatory bowel disease (IBD) have this HLA allele These individuals (~3.5% of IBD) may benefit from B cell depletion (such as achieved via CAR T). nejm.org/doi/full/10.1056/NE… nejm.org/doi/full/10.1056/NE…
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Mutation-dependent responses to sleep and exercise in clonal haematopoiesis @Nature @cam_phd @SinaiImmunol nature.com/articles/s41586-0…
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Essential crosstalk between sirtuins and the sex chromosomes, with SIRT7 safeguarding X-chromosome integrity and dosage balance with autosomes @Nature @MassGenBrigham 🇺🇸🇪🇸 nature.com/articles/s41586-0…
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By preventing excessive T cell receptor clustering, the phosphatase PTPN22 dampens T cell activation @scisignal @ssimoncelli @ucl science.org/doi/10.1126/scis…
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Limited adaptability of virtual memory CD8 T cells to chronic viral infection @CincyResearch @CincyImmunology @FrontiersIn frontiersin.org/journals/imm…
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Cross-presentation of citrullinated antigens drives cytotoxic CD8 T cell responses in rheumatoid arthritis @biorxivpreprint biorxiv.org/content/10.64898…
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Preprint @DrAaronJJohnson Virus-specific CD8 T cells rapidly populate and persist in skull bone marrow after brain infection researchsquare.com/article/r…
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Inflammatory cytokines induce new cancer dependencies @NatureGenet @broadinstitute @MangusoLab nature.com/articles/s41588-0…
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