Postdoctoral Fellow | Yamanaka-Ohmura lab | 北京脑科学与类脑研究所 (CIBR) | Burdakov lab alumni | PhD Neuroscience | 🇺🇸 → 🇨🇭 → 🇨🇳
Joined November 2019
- Tweets 49
- Following 107
- Followers 70
- Likes 249
7 Photos and videos
Pinned Tweet
6 Aug 2024
With only so many hours in a day, many of us struggle to find the time to exercise. What allows us to maintain exercise-behavior when other activities vie for our attention? The first paper of my PhD published in @NatureNeuro suggests orexins! (1/8) nature.com/articles/s41593-0…
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Catalogue entries for more than 100 antibodies sold by the research services and supply company Thermo Fisher Scientific contain images that have apparently been manipulated, according to a pair of science sleuths.
go.nature.com/4wZqGEE
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Alexander Lee Tesmer retweeted
May 13
Where, exactly, does learning happen in the brain?
Out now @Nature , we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster, but at a cost.🧵 #neuroscience
nature.com/articles/s41586-0…
Open link: rdcu.be/fiyrS
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Alexander Lee Tesmer retweeted
21 Dec 2025
We are thrilled to share our new preprint!
What happens to memory when >50% of synapses disappear?
We show that artificial hibernation induces massive neuronal remodeling, yet preserves memory through protected circuit architecture.
biorxiv.org/content/10.64898…
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Alexander Lee Tesmer retweeted
2 Oct 2025
Online now: Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum dlvr.it/TNRPCh
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Alexander Lee Tesmer retweeted
28 Sep 2025
A hypothalamic circuit for anticipating future changes in energy balance. biorxiv.org/content/10.1101/… #biorxiv_neursci
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2 Sep 2025
In mice, orexin neurons multiplex the encoding of rapid body-movements with slow changes in blood glucose. The extent to which these neurons correlate with movement across behavioral and metabolic states surprised us! Now a Version of Record in @eLife. doi.org/10.7554/eLife.103738…
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Alexander Lee Tesmer retweeted
30 Jul 2025
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in @Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ nature.com/articles/s41586-0…
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Alexander Lee Tesmer retweeted
18 Jul 2025
ALT Aerial view of the White House with multiple red map pointer icons above it.
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Alexander Lee Tesmer retweeted
10 Jul 2025
(1/3) Excited to introduce our new GRAB sensors for a series of steroid hormones! These tools enable real-time detection of steroid hormone dynamics in vivo🐭🧠.Happy to share these sensors and welcome any feedback!Please contact yulonglilab2018@gmail.com for information.
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Alexander Lee Tesmer retweeted
10 Jul 2025
Just released today in Nature Communications.
“Body temperature regulates glucose metabolism and torpid behavior”
Using a hibernation-like mouse model (QIH), we uncovered key links between thermoregulation and glucose metabolism.
doi.org/10.1038/s41467-025-6…
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Alexander Lee Tesmer retweeted
2 Jul 2025
In our Learning Club @CompNeuro_lab tomorrow (= July 3rd, Thursday, 2 PM CET),
@AlexanderTesmer will tell us about his recent paper (biorxiv.org/content/10.1101/…). If you'd like to attend, send an empty email to virtual-talk-link-request@cmclab.org to get the link! Thanks Alex!
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Alexander Lee Tesmer retweeted
7 Jun 2025
Be skeptical of any analysis in which the least powerful people are the most responsible for your problems
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25 May 2025
The future of science is Chinese. It’s not just the USA who is falling behind; we feel it here in Europe as well. Politics, budget cuts, and a general glorification of ignorance are poisoning the whole of western science.
25 May 2025
Universities ranked by research output...look closely. Now that @Harvard has been kneecapped, there will be no U.S. university left in the top ten. Hats off to China. nature.com/nature-index/inst…
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Alexander Lee Tesmer retweeted
24 Apr 2025
Super excited to share my PhD work, out now in @Nature. Here, my fantastic coauthors and I delved into whether mice could form memories of temperature experiences. 🐭💭❄️
Check out our tweetorial 🧵below:
Full paper at: nature.com/articles/s41586-0…
24 Apr 2025
Very excited to share part of my postdoctoral work from the @RyanLabTCD, out now in @Nature. Here, my brilliant co-author @Andrea_MZamora and I explored the link between memory engrams and whole-body metabolism.
A thread: 🧵
nature.com/articles/s41586-0…
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13 Mar 2025
Absolutely an honor to meet your lab! Great stuff happening in Beijing, thanks for hosting me😊!
13 Mar 2025
It was a great talk given by rising star @AlexanderTesmer from Orexin expert, Prof. Denis Burdakov lab, ETH, Zürich. Thank you for sharing newly interesting stories with us. 👏👏👏
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12 Mar 2025
Hunger-driving AgRP neurons are REM-active, and similarly re-activate during cataplexy. Hot off the press from the Burdakov lab!
biorxiv.org/content/10.1101/…
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Alexander Lee Tesmer retweeted
2 Mar 2025
The first step of any meaningful pursuit is to severely underestimate its difficulty.
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25 Feb 2025
Newest paper is on BioRxiv! We examine hypothalamic orexin (and MCH!) -producing neurons for their role in regulating decision policy complexity. Huge thanks to my supervisors @DeBurdakov and @RafaPolania
biorxiv.org/content/10.1101/…
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Alexander Lee Tesmer retweeted
13 Feb 2025
Our new paper is out in @CellReports
We show an inhibitory response of Orexin receptor type 2 (Ox2R) in a subset of MCH neurons.
doi.org/10.1016/j.celrep.202…
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7 Feb 2025
Reviewed preprint is online in @elife: Reviewers raised some important points, revisions coming soon!
Orexin population activity precisely reflects net body movement across behavioral and metabolic states doi.org/10.7554/eLife.103738…
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