@AlexanianLab profile picture
Alexanian Lab @AlexanianLab

Organic synthesis, organometallic reaction development, and radical C–H functionalization at UNC Chapel Hill.

Joined August 2016
  • Tweets 147
  • Following 146
  • Followers 4,117
73 Photos and videos
For future lab updates we have moved to Bluesky, connect with us there! bsky.app/profile/alexanian-l…
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Congratulations to Jack and Richard on their recent publication in JACS @J_A_C_S! They report a novel homologation method that is applied to several drug and natural product derivatives containing carboxylic acids. Make sure to check it out! @uncchemistry pubs.acs.org/doi/full/10.102…

Homologation of Carboxylic Acids Using a Radical-Polar Conjunctive Reagent

Homologations of organic molecules that add a carbon atom to the substrate are useful in drug discovery to access compounds with improved properties that otherwise present a synthetic challenge....

pubs.acs.org
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Alexanian Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
21 Nov 2024
Homologation of Carboxylic Acids Using a Radical-Polar Conjunctive Reagent | Journal of the American Chemical Society @Alexanianlab @UNC @TotalSyntheses #Homologation #CarboxylicAcid #Radical #Polar #Conjunctive pubs.acs.org/doi/10.1021/jac…

Homologation of Carboxylic Acids Using a Radical-Polar Conjunctive Reagent

Homologations of organic molecules that add a carbon atom to the substrate are useful in drug discovery to access compounds with improved properties that otherwise present a synthetic challenge....

pubs.acs.org
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Congrats to our newest Ph.D. candidate! Way to go Jack 🍾
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Congratulations to our second-year Raina on being awarded a poster presenter award at the inaugural UNC Women in Chemistry Symposium last month! Way to go Raina 🎉
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Congrats to Ashley and Justine on their recent publication in @angew_chem way to go SPT team! 🎉 Make sure to give it a read! onlinelibrary.wiley.com/doi/…

C(sp3)−H (N‐Phenyltetrazole)thiolation as an Enabling Tool for Molecular Diversification

The (N-phenyltetrazole)thiolation of aliphatic and (hetero)benzylic C−H bonds allows access to N-phenyltetrazole thioethers which are elaborated in diverse fragment couplings for C−C, C−O, or C−N...

onlinelibrary.wiley.com
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Belated congratulations to our most recent Ph.D. candidate John Brymer on passing his qualifying exam! Way to go John 🎉
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Congratulations to our newest Ph.D. candidate Michael Rodriguez on passing his qualifying exam today! 🍾
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Hot off the press! Check out Mason's and Alex's recent publication on the Cobalt-catalyzed synthesis of amides from alkenes and amines in @ScienceMagazine This is a paper that you will not want to miss! 🥳 science.org/doi/10.1126/scie…

Cobalt-catalyzed synthesis of amides from alkenes and amines promoted by light

A simple cobalt catalyst active for hydroformylation can also couple alkenes, amines, and carbon monoxide under photochemical conditions.

science.org
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Belated congratulations to Dr. Austin Miller on his thesis defense!
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Alexanian Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
30 Nov 2023
Synthesis of N-Alkylindoles from N,N-Dialkylanilines via [4 1] Annulative Double C–H Functionalization | Journal of the American Chemical Society @AlexanianLab @uncchemistry @UNCResearch @UNC #Indoles #Annulation #CHFunctionalization @TotalSyntheses pubs.acs.org/doi/10.1021/jac…

General Synthesis of N-Alkylindoles from N,N-Dialkylanilines via [4 1] Annulative Double C–H...

Strategies enabling the construction of indoles and novel polycyclic heterocycles from simple building blocks streamline syntheses in synthetic and medicinal chemistry. Herein, we report a C–H...

pubs.acs.org
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Congrats to our superstar post-doc team Bowen and Frederik on their recent publication in JACS! They've developed a new strategy for the construction of indoles and novel polycyclic heterocycles from simple building blocks, make sure to check it out! pubs.acs.org/doi/full/10.102…

General Synthesis of N-Alkylindoles from N,N-Dialkylanilines via [4 1] Annulative Double C–H...

Strategies enabling the construction of indoles and novel polycyclic heterocycles from simple building blocks streamline syntheses in synthetic and medicinal chemistry. Herein, we report a C–H...

pubs.acs.org
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The group had a great time at Drive Shack last Friday. It was quite the par-tee.
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Alexanian Lab retweeted
Jill W. Alty@jillalty
10 May 2023
Check out the latest in polymer C–H functionalization: polyesters! Featuring an easy-to-make xanthylamide reagent, regioselectivity assignment, & mechanical analysis. Congrats to @Victori_aB, @miaaborden1, @Frank_Leibfarth, @AlexanianLab & all the authors pubs.acs.org/doi/10.1021/acs…

Modifying Poly(caprolactone) Degradation through C–H Functionalization

There is a growing need for degradable polymers for applications in sustainable plastics and medical implants. To enhance the utility of degradable polymers, both better understanding of the factors...

pubs.acs.org
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5th year Ashley is putting our new EcoChyll to good use! Thanks @ecodyst
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Alexanian Lab retweeted
Leibfarth Research@LeibfarthGroup
10 May 2023
Out today in @MacroJrnls_ACS: @Victori_aB, @miaaborden1, and @jillalty, in collaboration with @AlexanianLab and @AFResearchLab, showcase the C-H Func. of poly(caprolactone) and its effects on degradation. Congratulations to everyone!! doi.org/10.1021/acs.macromol…

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Congratulations to our second-year Justine Drappeau on passing her candidacy exam 🥳
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Huge congratulations to our newest Ph.D. candidate Richard Kim on passing his second-year candidacy exam 🎉🥳
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The lab had a blast this past weekend explaining the chemistry of slime to future scientists at the UNC Science Expo! @moreheadplanet
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Alexanian Lab retweeted
UNC-Chapel Hill Chemistry@uncchemistry
3 Apr 2023
Congrats to our grad students Samantha Clouthier, Justine Drappeau, Don McTaggart, Caroline Mohler, Evan Stair, Olivia Steiner, Charles Teeples and Sydney Towell, recipients of the #NSFGRFP!❤️The fellowships recognize outstanding grad students. Read more: chem.unc.edu/?p=24763
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