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Ances BioImaging Laboratory @AncesLaboratory

The Ances Lab is a neuroscience research lab at WUSTL School of Medicine, focused on neurodegeneration (including Alzheimer Disease, Down Syndrome, HIV and CJD)

Joined November 2020
  • Tweets 321
  • Following 81
  • Followers 458
119 Photos and videos
Dr. Julie Wisch, longtime Ances lab member, recently received a KL2 award to pursue an investigation of blood-based biomarkers in Down Syndrome. We're excited to share the goals and planned impacts of this project, which will occur in the next 2 years.
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Happy World Down Syndrome Day!!! 🤩 Today we celebrated in style, rocking our crazy socks in honor of an incredible community that inspires us every single day. Here’s to continuing to advance research, inclusion & longevity for this amazing community 💙💛 #WorldDownSyndromeDay
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We had so much fun at the @dsagsl's Rock21 Concert this weekend! It was awesome to see all of our friends up on stage slaying it! @abc_ds_
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Dr. Ances had the pleasure of presenting at the Child Neurology Society (@ChildNeuroSoc) Annual Meeting last week. He had a great time meeting new colleagues and even running into old lab members! @abc_ds_
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🚨Big news! We are thrilled to share that Omar Abdelmoity, an undergraduate researcher in our lab, has been awarded the prestigious Goldwater Scholarship! 🌟 Omar’s work is already reshaping how we understand Alzheimer’s disease. (1/3) nam10.safelinks.protection.o…

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Omar has characterized brain metabolism in genetic forms of AD, investigated the importance of APOE4 in Down Syndrome and presented his work at multiple conferences, including those hosted by both NIH and HAI. (2/3)
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Omar is the kind of bold, curious, and driven scientist the future of medicine needs. We’re so proud of his work, his leadership, and the excellence he brings to our lab every day. Congratulations, Omar—you’ve earned this! 🎉(3/3) #GoldwaterScholar #ADresearch #NeuroTwitter
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We had such a great time at the @dsagsl’s Annual Trivia Night last weekend! We got to see so many of our friends and help raise money for this incredible organization! What an honor it is to be a part of this amazing #Downsyndrome community!! Our hearts are full! 💙💛💙 @abc_ds_
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We had a wonderful time at our Annual Ds Participant Breakfast! It's our favorite day of the year! Thanks to all the participants for making our jobs so enjoyable. We love working with you & you always make our days brighter! @abc_ds_ #Downsyndrome #Research #AlzheimersDisease
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Had a great time at the Human Amyloid Imaging Conference in San Juan, Puerto Rico! It was wonderful to meet up with so many amazing colleagues! #HAI #brainimaging #HAI2025
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If you missed Dr. Ances' presentation at @WashUNeurology Grand Rounds a few weeks ago, you can watch it now on our website at the link below! sites.wustl.edu/.../for.../p… @abc_ds_ @dsagsl #downsyndromeawareness #downsyndrome #research
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We had so much fun celebrating Halloween in the office yesterday! We love working together with such a great team!
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Dr. Ances is presenting at WashU Neurology Grand Rounds!! He will be speaking about current Ds studies available now and what the future looks like for clinical trials and treatments. You can join on zoom! Details below: Friday, 10/18/24, 7:45-8:45am wustl-hipaa.zoom.us/j/937085…
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Dr. Ances is giving a webinar about HIV Associated Neurocognitive Disorders (HAND) on Thursday, October 10th at 10am! If you're interested in learning more about #HAND you can register at the link below! #HIVAwareness #HIVresearch #HIV #hivaids register.gotowebinar.com/reg…
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Check out the podcast where I discuss our Vulnerability and Resiliency in the Aging Adult Brain Connectome #AABC study! omny.fm/shows/total-informat… You can also find more info on the study here: agingadultbrainconnectome.wu…
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Step Up of Down Syndrome is finally here! We're so excited to hang out with all our friends on Sunday! If you haven't joined our team, there is still time to support the Down Syndrome Association of Greater St. Louis! @dsagsl #SUDS2024 Sign up here - p2p.onecause.com/suds2024

Step Up for Down Syndrome 2024

The Down Syndrome Association of Greater St. Louis serves more than 2200 individuals with Down syndrome and their families, through every stage of life. We envision a community where all people with...

p2p.onecause.com
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Community Living had a pancake breakfast to fundraise for their adult recreation program. They had great breakfast, music, & outdoor games. The facility has a sensory room, accessible bathrooms, and a large outdoor playground for the kids. Thanks for having us! @abc_ds_
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In our latest collaboration with @abc_ds_ and DIAN, we compared tau pathology in Down Syndrome and Autosomal Dominant Alzheimer Disease (AD). doi.org/10.1016/S1474-4422(2… (1/6)
In Down syndrome, the most common regions with elevated tau burden were subcortical areas (amygdala, hippocampus, and pallidum) and the entorhinal cortex (figure 1A, B). For autosomal dominant Alzheimer's disease, the most common region with elevated tau burden was the fusiform gyrus, followed by the medial temporal lobe. Subcortical tau was observed in a later Gaussian mixure model-derived stage (figure 1C, D).

ALT In Down syndrome, the most common regions with elevated tau burden were subcortical areas (amygdala, hippocampus, and pallidum) and the entorhinal cortex (figure 1A, B). For autosomal dominant Alzheimer's disease, the most common region with elevated tau burden was the fusiform gyrus, followed by the medial temporal lobe. Subcortical tau was observed in a later Gaussian mixure model-derived stage (figure 1C, D).

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For a given level of amyloid burden, individuals with Down Syndrome had more tau pathology than individuals with Autosomal Dominant AD. (5/6)
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Taken together, this suggests that Alzheimer Disease progresses faster in Down Syndrome than in Autosomal Dominant AD, and that drug interventions may need to be targeted for a more specific time window in Down Syndrome. (6/6)
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