Building the DeSci Alliance for the founders, funders and friends of DeSci. Join us now! link in bio

Joined April 2008
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A few weeks old and yet it sticks in my mind like a gif on loop. 🔁
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Big.
US retail spot margin trading is live on Kraken Pro. Up to 10x leverage. Long or short. CFTC-regulated. Unleash your trading potential. kraken.com/features/margin-t… *Eligibility restrictions apply
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Everyone is talking about micro payments… @levirybalov is out here playing chess. Agents need infra and @arkhai_io has it!
The last post from our whitepaper series is out! We cover what you can build with today - escrow and arbitration contracts, git commit marketplace, agentic RAG, and our upcoming generalized, agent-driven marketplace (including RL agents for pricing compute and energy). Not mentioned are our natural language agreements, but you should check those out too :)
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Andrew Hemingway retweeted
Can we possibly find anything better to do with all the idle compute resources wasting away in data centers, homes, and businesses? That's the central question that this post from our whitepaper series addresses.
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Are you seeing what’s happening in NH?
Looking forward to speaking at @NHLibertyForum on how New Hampshire can become a leading hub of biotech innovation by passing bills like @KesselringSteve's HB 1734 and @cole4nh's HB 1735.
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Andrew Hemingway retweeted
Looking forward to speaking at @NHLibertyForum on how New Hampshire can become a leading hub of biotech innovation by passing bills like @KesselringSteve's HB 1734 and @cole4nh's HB 1735.
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It’s the most wonderful time of the year!
11 Dec 2025
It's time for our annual big ideas. Here are 17 things that various a16z crypto partners (plus a few guest contributors) are excited about for what’s ahead in 2026. On topics ranging from agents and AI; stablecoins, tokenization, and finance; privacy and security; to prediction markets, SNARKs, and other applications… to how we’ll build. Find the full post here: a16zcrypto.com/posts/article…
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Have you seen this?
7 Dec 2025
4x4 rotation collage of c5 symmetric synthetic protein backbones I made using rfdiffusion -> pymol
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Huge fan of @MattPRD and love what he has done here. But may I suggest an edit? Most people are trapped in small thinking or vague goals. Most are so small that they will never inspire action or command attention. @MattPRD what if the first step was a filter that helped users think bigger and more tangible. I think this would really increase the effectiveness of the outcome. Then you could add on a daily coach that would give you coaching and guidance each day and track your progress against each step. Just some thoughts. Appreciate you.
19 Nov 2025
I built goalpillars.com over the weekend because I wanted to make a Harada style dream sheet based on the one Shohei Ohtani used to become the #1 draft pick. Turns out I wasn’t the only one! 2,000 people have now used it to make their own goals. This week I’ve been building out a full Harada style AI coach for the site and I can’t wait to finish it because I can’t wait to use it myself. It’s for me, but you can use it too. Sign up for the waitlist!
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On live! Will be mentioning some of my top projects! @arkhai_io tops my list. x.com/i/spaces/1BRJjgyMARpxw
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Coming right up!! Join us!
18 Nov 2025
Science doesn’t fail from lack of ideas, it fails from lack of funding. Tomorrow, we’re co-hosting a Space with @ResearchHub, and prominent voices in DeSci to unpack how research funding works today, and how it should work. 12 Noon EST. Set reminder. 👇 x.com/i/spaces/1BRJjgyMARpxw
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This will be a good one. Join us!
18 Nov 2025
Science doesn’t fail from lack of ideas, it fails from lack of funding. Tomorrow, we’re co-hosting a Space with @ResearchHub, and prominent voices in DeSci to unpack how research funding works today, and how it should work. 12 Noon EST. Set reminder. 👇 x.com/i/spaces/1BRJjgyMARpxw
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This is the path to autonomous relentless scientific discovery.
12 Nov 2025
The difference between agents as tools and agents as economic actors is escrow and arbitration. With these, agents can hire each other for custom work, not just buy predefined services. Imagine agents negotiating complex deals, splitting tasks, sharing risks, and settling payments based on verified outcomes. That's why we integrated both ERC-8004 and the x402 payment standard with our smart contract suite, Alkahest.
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Andrew Hemingway retweeted
16 Nov 2025
I’ll share a small part of pickle.com Back in med school, I became obsessed with augmenting memory and dreamed of a Notion or Obsidian that completes itself. Today, we’ve built something close. My self-awareness is sharper and everything feels connected. I genuinely believe AI does not replace humans. It amplifies us. Huge respect to our engineers and designers who made this crazy thing real. Bubbles are the episodic units of my life that the system interprets from my raw data. Clouds are the system’s questions, its hypotheses about who I am. When I answer a cloud, it becomes a bubble again. There is so much personal data that I cannot fully demo it. Wish I could. This system understands me more deeply than anyone. Want to try it? Retweet and comment “memory.” I’ll DM you an access code to skip the waitlist.
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The dawn of cybernetic commerce.
6 Nov 2025
Ten thousand years of human commerce just became the beta version. v1.0 ships today. Introducing Arkhai, where intelligence meets agency.
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There is an elephant in the stablecoin hype room. It's called Fiat. Fiat is failing, and will fail. When it does, all fingers will point to the "crypto bros" who broke it and to their evil invention stable coins. I joined crypto to debase from Fiat, not to join in the party in a different costume. Asset backed currency is the answer.
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Keep an eye out here. You should bookmark this one.
Yield Bearing Stablecoin Ecosytem Map
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Attention Projects: If you are looking for a growth marketing leader let me know! I have one of the most influential leaders in DeSci looking for his next role. Send me a DM. Move fast!
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What’s your best advice?
What’s the best piece of advice? Context: I’m a 15yr old with hooper dreams and soaking up all the wisdom I can. Please give me your $2 worth!
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Kids having to much fun!
I am having a ball here!
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