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Andy Russell @AndyRusss

Postdoctoral Fellow @broadinstitute @insitubiology (Chen Lab) @HSCRB . Ex: @SangerInstitute @Cambridge_Uni @UniofOxford. He/him IG: @ajcrscience

Joined July 2009
  • Tweets 726
  • Following 1,138
  • Followers 867
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Andy Russell@AndyRusss
13 Dec 2023
Slide-tags adds spatial coordinates to single-cell sequencing measurements! Please explore the paper, published online today in @Nature! nature.com/articles/s41586-0…

Slide-tags enables single-nucleus barcoding for multimodal spatial genomics

Nature - Slide-tags enables multiomic sequencing of single cells and their localization within tissues.

nature.com
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Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing us to dive deeper into the complexity of tissue organization. Grateful for the amazing team and support from @insitubiology and @macosko! #ToolsOfTheTrade
Nature Reviews Genetics@NatureRevGenet
4 Nov 2024
Slide-tags enables spatial single-nucleus sequencing go.nature.com/48x06XP #ToolsOfTheTrade by Andrew J. C. Russell @AndyRusss @broadinstitute @insitubiology @HSCRB
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It was such a pleasure to meet everyone this past week in Heidelberg and be part of such a vibrant scientific community - thank you @EMBOFellows!
EMBO@EMBO
28 Oct 2024
More than 100 @EMBOFellows are meeting in Heidelberg. The postdoctoral fellows present their research, attend a mentoring session, receive training on a variety of topics and more. #EMBOat60
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Had fun talking about Slide-tags with @GenomeTDCC recently. Please check it out If you'd like an overview on what is is and what it can do! 🧬
GenomeTDCC@GenomeTDCC
28 Feb 2024
Slide-tags: Combining single-nucleus genomics with spatial measurements 🧬🔬 Hear from @AndyRusss, @jacksonweir4, Naeem Nadaf, and @insitubiology as they describe the development and application of this impressive technology youtu.be/4TJkLI4LINU
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Andy Russell retweeted
Dawn Chen@dawnchenx
2 Feb 2024
We are happy to share our latest long-range, programmable mutagenesis toolbox - the Helicase-Assisted Continous Editing (HACE) system - to achieve target-specific mutagenesis of the endogenous genome. (1/11) biorxiv.org/content/10.1101/…

Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

A major challenge in human genomics is to decipher the context specific relationship of sequence to function. However, existing tools for locus specific hypermutation and evolution in the native...

biorxiv.org
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Andy Russell retweeted
Evan Macosko@macosko
13 Dec 2023
Slide-tags unifies the single cell spatial genomics worlds. It solves three key problems with existing spatial methods: 1) Cell segmentation (the biggest problem) 2) robustness and scalability (well-powered case-control studies now possible) 3) Multiomics (ATAC, RNA, etc)
Broad Institute@broadinstitute
13 Dec 2023
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags
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Slide-tags adds spatial coordinates to single-cell sequencing measurements! Please explore the paper, published online today in @Nature! nature.com/articles/s41586-0…

Slide-tags enables single-nucleus barcoding for multimodal spatial genomics

Nature - Slide-tags enables multiomic sequencing of single cells and their localization within tissues.

nature.com
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This wouldn’t have been possible without a fantastic team: @jacksonweir4*, @Naeemnadaff*, Matthew S, Vipin K, @SandeepKambham2, @RuthRaichur, Gio M, @soph_liu, @KarolBalderrama, Charles V, @Vignesh_Shan, @Luyi_T, Catherine W, Bryan I, Charles Y, @macosko†, @insitubiology†
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Discover more in my original preprint thread here: x.com/AndyRusss/status/16432…

Andy Russell@AndyRusss
4 Apr 2023
Single-cell or spatial? Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics ➡️ doi.org/10.1101/2023.04.01.5…
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Single-cell or spatial? Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics ➡️ doi.org/10.1101/2023.04.01.5…
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Please check out the preprint which contains a lot more information, and links to the data! Thank you to everyone at @broadinstitute and @HSCRB who made this possible! @EMBO for funding me.
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This was a really fun collaborative project with with: @jacksonweir4*, @Naeemnadaff*, Matthew S, Vipin K, @SandeepKambham2, @RuthRaichur, Gio M, @soph_liu, @KarolBalderrama, Charles V, @Vignesh_Shan, @Luyi_T, Catherine W, Charles Y, @macosko†, @insitubiology†
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Andy Russell retweeted
Alex Cagan@ATJCagan
9 Feb 2023
Andrew Russell on Slide-Tags: single-nucleus high-resolution multi-modal spatial genomics #AGBT23
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Proud to announce that our paper is out now➡️ doi.org/10.1016/j.chom.2022.… We explored how malaria parasites differentiate from asexual replication into sexual cell types ♂️♀️ - please see Theo's excellent 🧵 below for more info and acknowledgements!

Theo Sanderson@theosanderson
11 Jan 2023
Now out in journal form: sciencedirect.com/science/ar… Malaria parasites replicate asexually in the bloodstream, however a subset form ♂️ and ♀️ sexual cell types that when sucked up by a 🦟 undergo sexual reproduction. But how? 🧵
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Proud to announce that our paper is out now➡️ doi.org/10.1016/j.chom.2022.… We explored how malaria parasites differentiate from asexual replication into sexual cell types ♂️♀️ - please see Oliver's excellent 🧵 below for more info and acknowledgements!

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