20 yr. search for an effective #Alzheimers drug. Following drug developments for my family. Posts are my observations/opinions (not medical/investment advice).

Joined March 2022
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Honoring my Father and Big Brother, who were taken by #Alzheimers, I composed/performed/recorded an instrumental called "Taking Flight" and added it to the following tribute video. youtu.be/DAYhJa9sjCY
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Although not a shock at this point, today's $SAVA news still greatly saddens my family & me. We were all so enthusiastically hoping that simufilam would be the effective treatment for Alzheimer's that we have been searching for (the past 20 years). My/Our quest will continue.
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New 3/20/25 $SAVA ClinicalTrials.gov update. Possible interesting update to "IPD Sharing"? As per AI: "IPD sharing refers to the practice of making individual participant data (IPD) from clinical trials available to researchers who were not part of the original study team."
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Cassava updated ClinicalTrials website for $SAVA REFOCUS trial today (see Sub-Post for details). Below is my Est. Patient Completion Timeline. It appears ~620 patients may have completed REFOCUS. Chart assumes 75% patient retention into 12/30/24. [Corrections/Critiques Welcome]
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Below is a minor correction to the originally posted Estimated Patient Completion Timeline chart. Please Note: the slight reduction in the projected/estimated patient dosing completions for the five grey (never to be completed months).
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Today Cassava updated ClinicalTrials website for $SAVA Phase 3- REFOCUS trial. Below are highlighted updates.
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FYI: Today, $SAVA updated ClinicalTrials.gov site for the 90 patient "Open Label Extension" that was offered to (I believe) the Phase 2b Study patients. The "Overall Status" for this "PTI-125-04 Study" has been changed to "Terminated".
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FYI: On 1/15/25, $SAVA updated ClinicalTrials.gov site for the 90 patient "Open Label Extension" that was offered to (I believe) the Phase 2b Study patients. "Overall Status" is now "Completed" and this OLE ended ~10 weeks sooner than the originally estimated 2/14/25 date.
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FYI: $SAVA updated "Pharmacokinetic Study" on ClinicalTrials.gov as "Completed" (Not Terminated), approx. 2 months sooner and with 7 patients less than Est. Enrollment. I'm still curious to see the results from this and the "Absorption, Metabolism Excretion" Study.
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Cassava Sciences $SAVA just provided the following update (see link below for details) cassavasciences.com/news-rel…
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Interesting Development? $SAVA 11/25/24 PR stated: "We will also be discontinuing the Open Label Extension study.” However, 12/12/24 ClinicalTrials.gov updates include: "Active, Not Recruiting", Completion Est. 3/28/25, 1081 Actual Enrolled, and two sites readded into trial.
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Many thanks to $SAVA, all trial participants and their families. I was so looking forward to passing on great news to my family. My 5 sisters & I hoped to be on efficacious & FDA approved #Simufilam ASAP. My search will continue for an effective #ALZ drug for my & all families.
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Things are really getting interesting with $SAVA! Can't wait for the webcast tomorrow!
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IMHO: Today's $SAVA SEC filing for new "Chief Clinical Dev. Officer" is extremely positive. A small Biotech like @CassavaSciences doesn't land a Head, Senior Director, Clinical Lead, Professor w/ over 22 yrs at 2 of the largest Biotechs, w/o offering her serious future potential!
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Thank you @MattNachtrab, cureguardian.org and especially Manny & Family ...for telling "Manny's Story", his #ALZ struggles & years of daily successes while taking $SAVA #Simufilam. It fills my family, me & humanity w/ hope for a future without #Alzheimer’s as we know it.

Cassava Patient Family Testimonial, Manny's Story, goes live at 2pm Today youtu.be/TEl6SbXR5hc Cure Guardian has finished a video highlighting the experiences of one patient that has been on simufilam for 4 years. The drug is the only thing that changed in his life and it reversed his symptoms of #Alzheimers Simufilam is a drug that is in phase 3 trials from Cassava Sciences, $sava, and results will be out before the end of 2024. The video we are playing at 2pm EST on November 15th is one of MANY stories that we are hearing from patients and their families. We believe the data release before the end of the year will show simufilam is the biggest breakthrough in the Unfortunately, this drug has been attacked by short sellers and competitors. It is very important that the @US_FDA do not give into the pressure from short sellers and big pharma and they approve the drug as soon as possible. @RobertKennedyJr we need your support of researchers and biotechs innovating and finding cures to disease! These attacks successfully got the attention of the @DOJCrimDiv and they raided the researchers home at 9pm on a Monday days after the shorts released their reports. Dr. Wang has been a victim of massive government overreach and, I believe, the world will soon see that his drug is the biggest breakthrough in Alzheimer's research. He is was indicted earlier this year and has a motion to dismiss hearing on December 13th. I have been an advocate for the families that are in the clinical trials for 3 years now. I even formed a non-profit so others can join the fight against shaming researchers and biotechs pursuing cures to disease. We help researchers fend off the public attacks. 96.5% of accusations to the NIH and ORI result in finding of no research misconduct. cureguardian.org youtu.be/TEl6SbXR5hc
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I performed a side-by-side comparison of $SAVA's Aug-2024 and today's Nov-2024 slide deck presentations. Below are three slides that had more substantial changes (highlighted in light blue). I find changes to the "Intellectual Property" slide especially interesting.
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$SAVA P3-OLE enrollment is closing in on 1,150 patients. Below is my latest/revised chart that's based on patient enrollment/completion totals provided in @CassavaSciences 11/7/24 press release. And tracks closely w/ actual reported P3-OLE values.
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Below is my quick/paraphrased/positive take-aways from today's $SAVA conference call. Please see my sub-post if interest in listening to call or reading PR.
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Links to today's Conference Call and Press Release: 11/7/24 Conference Call Link (I believe only available for a limited time) cassavasciences.com/events/e… 11/7/24 Press Release cassavasciences.com/news-rel…

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