Investigating the cell biology of proteostasis and misfolded proteins in neurological disorders. Associate Prof. at Tel Aviv University.
Joined May 2019
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31 Photos and videos
Pinned Tweet
Jan 25
Our paper published online in @Brain1878. We identify a cancer-associated #ubiquitin enzyme as a potential therapeutic target in #Huntington's disease. @TAUMedFaculty @of_sagol
academic.oup.com/brain/artic…
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Avraham Ashkenazi retweeted
ONLINE NOW: Deubiquitinases at organelle quality control bottlenecks in neurodegeneration dlvr.it/TStKxH
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Our new review is online🙂: Deubiquitinases at organelle quality control bottlenecks in #neurodegeneration: @TrendsMolecMed @of_sagol cell.com/trends/molecular-me…
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Read the full paper here (free access):
authors.elsevier.com/a/1nDJ1…
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Together with Lisa Ellerby (Buck Institute), we discuss our recent Brain paper (academic.oup.com/brain/artic…) in a broader context.
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Avraham Ashkenazi retweeted
New online! Extracellular matrix remodelling in neurological diseases dlvr.it/TS9YvF
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Apr 15
Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes?
Check out the new Shifman / Meshorer labs collaborative review in TiG @TrendsGenetics , lead by our amazing joint student, Elad Dvir👇👇👇
sciencedirect.com/science/ar…
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Mar 15
Elegant study on that fit the unconventional secretion mode of TMEM16F: Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/…
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Avraham Ashkenazi retweeted
Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders — a Review by Carissa L. Sirois, Jiyoun Lee, Audrey L. Chambers & Xinyu Zhao
nature.com/articles/s41583-0…
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The most sensitive green and red #norepinephrine #sensors engineered to date are out in @naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @ERC_Research @snsf_ch @UZH_en @UZH_IPT doi.org/10.1038/s41592-026-0…
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Feb 28
Stochastic misfolding drives the emergence of distinct α-synuclein strains: Neuron cell.com/neuron/fulltext/S08…
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Feb 23
Elegant work. Congratulations to Julie and team. #Parkinson's disease #alpha-synuclein secretion
So excited to share our work on Glucosylceramide-induced ectosomes propagate pathogenic alpha-synuclein in Parkinson’s disease, now out @ Nature Cell Biology!
@NaturePortfolio
nature.com/articles/s41556-0…
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Feb 22
Check our new work @NatRevMCB . It was fun working with Gali Prag on this piece. Stay tuned for more research on this exciting topic from our lab. Thanks 🙏 to referee and editor for the feedback @of_sagol @TelAvivUni
New Online! The emerging importance of UBA6 in ubiquitylation and proteostasis dlvr.it/TR4B8m
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Avraham Ashkenazi retweeted
Feb 20
PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington’s Disease | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Feb 20
Our article commentary is out in @NatRevMCB. 🎉 Together with Gali Prag, we discuss the emerging functions of the #ubiquitin enzyme UBA6 in health and disease. @of_sagol @taumed
nature.com/articles/s41580-0…
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Feb 20
Stay tuned for more research from our lab on this exciting topic!
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Avraham Ashkenazi retweeted
We are excited to announce that the Parkinson’s Foundation and @ACSMNews, the world’s largest sports medicine and exercise science organization, have announced updated recommendations to provide safe and effective guidance on exercise for people with Parkinson’s disease.
The updated exercise recommendations were published following extensive review from subject matter experts, as well as members of the PD community who actively use the recommendations. Read more: Parkinson.org/about-us/news/…
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Feb 20
Congratulations Edward and team :beautiful work.
Feb 13
New from our lab: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
It resolves in organelles e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
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Feb 20
The consequences of this mechanism for prion-like aggregate spreading need to be explored. Congratulations! Nice.
A new paper reveals that adhesion GPCRs promote extracellular vesicle (EV) formation and EVs spread GPCRs into neighboring cells to activate G-protein signaling, providing a novel mechanism for cell-cell communication
nature.com/articles/s41589-0…
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Avraham Ashkenazi retweeted
New online! Towards biomarker-based diagnosis of Parkinson disease dlvr.it/TQxnwd
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