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Nature Methods @naturemethods

Nature Methods publishes cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Tweets by editors.

Joined March 2011
  • Tweets 5,725
  • Following 1,086
  • Followers 154,906
1,855 Photos and videos
Our June issue is live! 🎉 nature.com/nmeth/volumes/23/… On the cover, an absolutely gorgeous image of neurites and mitochondria in a brain organoid, captured using the MOSAIC microscope. Paper here: nature.com/articles/s41592-0…
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A Perspective discusses the use of external validation using independent datasets for improving human neuroimaging studies. @DScheinost nature.com/articles/s41592-0…

External validation improves generalizability, replicability and reproducibility in predictive...

Nature Methods - This Perspective promotes the use of external validation using independent datasets for human neuroimaging studies.

nature.com
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A Perspective discusses challenges in macromolecular ensemble prediction and the methodological advances that are needed. @stephanie_mul nature.com/articles/s41592-0…

From possibility to precision in macromolecular ensemble prediction

Nature Methods - This Perspective discusses current challenges in macromolecular ensemble prediction and the infrastructure and methodological advances needed to overcome these barriers.

nature.com
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Chromatix: a standardized framework for developing, sharing and reusing wave-optics simulations. @diptodipdeb @srinituraga @HHMIJanelia nature.com/articles/s41592-0…
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And read the associated Research Briefing here: nature.com/articles/s41592-0…

A fast open-source wave optics simulator

Nature Methods - We built an open-source library of wave optics models — Chromatix — that enables optics simulations to be scaled efficiently on modern computing hardware. Chromatix...

nature.com
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A Perspective provides minimum community standards and best-practice guidelines for hydroxyl radical protein footprinting-mass spectrometry. nature.com/articles/s41592-0…
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SAGE-net: a scalable, efficient sequence-to-function modeling framework for personal genome analysis. nature.com/articles/s41592-0…

A scalable approach to investigating sequence-to-function predictions from personal genomes

Nature Methods - Modeling the effect of DNA sequence variation on phenotypes such as gene expression faces unique challenges when deciphering inter-individual variation. This study presents a...

nature.com
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Brightness demixing: a method for simultaneously detecting different fluorophores in single-molecule localization microscopy based on brightness. @S_LevequeFort @LE_Laurent_ nature.com/articles/s41592-0…
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Neuropixels Opto probes combine high-density recording sites with optical waveguide-based light emission sites to simultaneously record neuronal activity and optogenetic stimulation. nature.com/articles/s41592-0…

Neuropixels Opto: combining high-resolution electrophysiology and optogenetics

Nature Methods - Neuropixels Opto probes combine high-density recording sites with optical waveguide-based light emission sites for simultaneous recording of neuronal activity and optogenetic...

nature.com
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Read the associated Research Briefing here: nature.com/articles/s41592-0…

Reading and writing neural activity with Neuropixels Opto probes

Nature Methods - High-density electrophysiology devices allow neuroscientists to observe spikes from large populations of neurons, and optogenetics allows them to drive or suppress those spikes. We...

nature.com
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TADShop: a study benchmarking 43 computational methods for identifying topologically associating domains. nature.com/articles/s41592-0…
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A correlative workflow combining cryo-EM and focused ion beam secondary ion mass spectrometry enables subcellular chemical mapping. nature.com/articles/s41592-0…

Subcellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging

Nature Methods - A correlative workflow combining cryo-EM and focused ion beam secondary ion mass spectrometry (FIB-SIMS) facilitates subcellular chemical analysis with high spatial resolution.

nature.com
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Read the News & Views highlighting this work, here: nature.com/articles/s41592-0…

Adding chemical identity to cryo-electron microscopy

Nature Methods - A correlative workflow combining cryo-electron microscopy and cryo-electron tomography with secondary ion mass spectrometry generates spatially registered chemical maps from the...

nature.com
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Decima learns to predict cell-type-specific gene expression based on DNA sequences. nature.com/articles/s41592-0…
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Read the News & Views highlighting this work, here: nature.com/articles/s41592-0…

Teaching an old dog new cells

Nature Methods - Two new methods show that bulk-trained sequence models can be efficiently adapted to predict gene regulation and variant effects at single-cell resolution.

nature.com
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High multiplicity of infection sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers. nature.com/articles/s41592-0…
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AreTomoLive: a preprocessing pipeline for cryo-ET that streamlines tomographic alignment, reconstruction and contrast enhancement. nature.com/articles/s41592-0…
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ENCORI is a comprehensive analysis platform and resource for exploring RNA-protein and RNA-RNA interactomes. nature.com/articles/s41592-0…

An encyclopedic regulatory and functional atlas of RNA interactomes

Nature Methods - ENCORI is a comprehensive analysis platform and resource for exploring RNA–protein and RNA–RNA interactomes.

nature.com
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Nature Methods retweeted
Nature Conferences@NatureConf
Jun 2
How are electron microscopy, methods and AI advancing physical and life sciences? Find out at our upcoming event featuring global experts and organized by @PrincetonMSE, @Nature, @naturemethods, @NatureCatalysis & @NatureMaterials Learn more>>go.nature.com/4vTFdBx
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MOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @Eric_Betzig @ABCUCBerkeley @legant_lab nature.com/articles/s41592-0…

A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms

Nature Methods - MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated...

nature.com
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