This is huge 10,000× faster 👀 "Researchers just developed an AI system called TITO that can simulate molecular dynamics up to 10,000-fold faster than conventional methods." "The model was trained across more than 12,500 organic molecules and 1,000 peptides, learning how molecular systems evolve over time." "Instead of calculating every femtosecond-scale step, the AI can effectively bridge molecular behavior from femtoseconds to nanoseconds while preserving the underlying physics." Thats why! Scientists will soon be able to explore drugs, materials, catalysts and biological systems dramatically faster than before. This could be one of the first real signs of AI accelerating scientific discovery itself.

Duplicate, diversify, repeat: The evolution of NOTCH2NL dlvr.it/TT1LxQ

New episode: BALI uses light to write combinatorial DNA barcodes for tunable spatial multiomics with subcellular resolution and RNA ATAC on the same tissue. Hear how LightScribe automates it: basebybase.com/episodes/bali…

New episode: we break down prime‑SGE, a multiplex prime editing screen that maps thousands of drug‑resistance variants across oncogenes and compares covalent vs non‑covalent EGFR inhibitor resistance. Listen: basebybase.com/episodes/prim…

New PaperCast Ep379: Long-read genomes reveal hidden structural and repeat variants in ASD, including novel DUP-DEL events, allele-specific FMR1 methylation, and rare-variant heritability estimates.… basebybase.com/episodes/long…

New PaperCast: Monoallelic PSMB8 variants disrupt immunoproteasome assembly and cause PRAAS with immunodeficiency via a dominant-negative mechanism — episode 378. Listen: basebybase.com/episodes/mono…

New PaperCast: ProteomeLM — a proteome-scale language model that predicts protein–protein interactions and gene essentiality across taxa faster and more accurately than coevolution methods. Listen now: basebybase.com/episodes/prot…

New PaperCast Base by Base: Pfh1 helicase balances ATP-dependent unwinding and ATP-modulated rewinding at forks; mitochondrial SSB spRim1 accelerates both activities. Listen now: basebybase.com/episodes/pfh1…

PaperCast S2E375: Biallelic DSCAM loss causes a recessive neurodevelopmental syndrome with nystagmus and cone-pathway retinal dysfunction. Listen now basebybase.com/episodes/bial…

New PaperCast: DNA-guided Cas12a is rewired to recognize and cleave RNA, enabling attomolar diagnostics (SLEUTH) and cellular knockdown proof-of-concept. Hear the structural and functional story: basebybase.com/episodes/dna-…

Rare disease diagnoses can rely on exome sequencing, but answers may be hiding in noncoding regions. 🧬 PromoterAI is a new deep learning tool that identifies pathogenic promoter variants, which may account for up to 6% of rare disease genetic burden 🔍 science.org/doi/10.1126/scie…

Great new genomic resources for inflammatory bowel disease (IBD) from the International IBD Genetics Consortium 1⃣The largest to date IBD GWAS in 125,992 cases & 1.2M controls showing 619 independent signals at 420 IBD regions accounting for 77–80% (!) of SNP-based heritability

It’s undeniable: the AI scientists are here. On May 19, Nature published three papers that gave the field one of those “something just changed forever” moments. Here’s what you need to know. 🧵 (1/6)

Today, we introduced Gemini For Science, a collection of experimental tools designed to expand the scale and precision of scientific exploration. Included in Gemini for Science are three (!!!) brand new Google Labs experiments. Meet your new AI research partners: 🧵👇

My first PhD paper is out now in @Nature! Very grateful to have worked with the FutureHouse team on this, and a big shoutout to my co-first author @agreeb66 😀

New PaperCast: researchers report a ciliate nuclear genetic code where UAA→Lys and UAG→Glu — the first case of UAA and UAG coding different amino acids. Hear the findings and implications in Base by Base: basebybase.com/episodes/non-…

SV-GWAS is highly accessible now! Our new paper in @NatureGenet shows how HiFi long-read assemblies let us repurpose SNP-based GWAS data to impute structural variants (SVs) to interrogate their role in human complex traits and diseases. @WeiyangBai nature.com/articles/s41588-0…

Today we all lost our jobs..... Three Nature papers showing that scientists in the conventional sense are obsolete At least read the first one.... the AI replaced all things that the scientist does .... nature.com/articles/s41586-0…

New episode: How much of the IQ–SES link in young adults is genetic? TwinLife twin data show IQ at 23 predicts SES at 27, with genetics explaining most of the association—listen to PaperCast Base by Base: basebybase.com/episodes/gene…

New PaperCast: single-nucleus epigenomics links genetic risk to disease-specific glial states in AD, PiD and PSP—hear how dynamic chromatin, MPRA and SOX10 pinpoint modifiable lysosome and trafficking pat… basebybase.com/episodes/epig…