Transient contractile arrays. Part of the Center for Quantitative Cell Imaging (@UWCQCI) at UW-Madison. Tweets mostly by @ZacSwider and @AniMichaud1.

Joined March 2019
44 Photos and videos
Pinned Tweet
20 Sep 2020
Join @AniMichaud1 on a tour of the Bement lab @UWMadison and see what we're all about! #CellBiology youtu.be/it0aRx8-0Vo
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Bement Lab retweeted
26 Mar 2022
Any #microscopy friends have any suggestions for a water stage cooler/pump? I'm specifically interested in something to slowly flow water through a light sheet imaging chamber so it will need a very slow and consistent flow rate. Maybe @ZakSwartz ?
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Our latest pre-print is up on @bioRxiv! Here, @AniMichaud1 et al. identified Ect2 and RGA-3/4 as core components of cytokinetic cortical excitability. We also show that immature Xenopus oocytes are a powerful model for characterizing excitability. A 🧵... biorxiv.org/content/10.1101/…
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Modeling and experiments showed that Ect2 and RGA-3/4 are major drivers of this circuit, and just altering the relative levels of these two players produced a variety of cortical behaviors in an otherwise quiescent oocyte cortex!
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How does RGA get recruited to cortical waves and what exactly is the nature of its relationship with F-actin? We aren't sure, but we plan to use immature frog oocytes and modeling to address these questions!
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