Excited to highlight our newest work on an induced proximity-based targeted transcriptional repression platform termed Transcriptional Repression via Active Chemical Epigenetic Reprogramming (TRACERs)! Congrats to @CEStieger and co-authors and our @NovartisScience collaborators!! (1/9) pubs.acs.org/doi/10.1021/acs…

Maternity induces lasting gene-expression changes in mouse brains thetransmitter.org/pregnancy… A very nice discussion of our manuscript (led by @chanjeneration) recently published @Nature, entitled "Dopamine drives persistent remodelling of the maternal brain."

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

🎉HUGE CONGRATULATIONS @wuzhengherbert! One of the country's best young #Neuroscientists, the #FriedmanBrainInstitute’s Dr. Herbert Zheng Wu has earned a 2026 @McKnightFdn Scholar Award for his cutting-edge work. We are THRILLED and incredibly PROUD! Again, congratulations!👏

A single dose of engineered immune cells has helped two men and one woman to receive life-saving kidney transplants. Their bodies would normally reject donated organs. go.nature.com/4fZ8uoG

How #Pregnancy & the #Postpartum period trigger lasting changes in the #MaternalBrain remains unclear. Here, @chanjeneration, @themazelab, et al. @IcahnMountSinai investigated the persistent effects of reproductive experience in the maternal brain @Nature nature.com/articles/s41586-0…

Motherhood induces transcriptional changes in the brain that endure beyond short-term hormonal shifts go.nature.com/4v09H3o

So excited to highlight our new work led by @chanjeneration, a postdoc in my lab recently awarded a K01 and BWF award (and on the job market!), out in @Nature! This project identifies a novel role for dopamine in permanently remodeling the maternal brain through histone H3

Thrilled to share my main postdoctoral work out @Nature! This project tackles a fundamental question: how do pregnancy and postpartum experiences promote lifelong changes to the brain? nature.com/articles/s41586-0…

We resubmitted this paper a week ago. This paper has been up on preprint for a year now while in revision. There is uniform consensus that this is a very big concept. There is (as always will be) debate as to how throughly we have proven the existence of these polyorganic neurons that have been brought up for decades. However, a huge advantage of the preprint process is that it gives time for others to replicate or even find orthogonal motifs that support our claims. We now know that many labs have either prospectively found these or retrospectively found them in their datasets (serious labs). We also know there are motifs in other parts of the nervous system that mirror what we found, discovered by others. Astute patients have reached out saying they truly feel this is why they have visceral pain (some of them world class scientists). This, to me, is the beauty of science and the preprint process. We do not validate through replication from a single process, assay, or lab. We crowdsource the science and let time ferment the truth out through external validation. Congrats @ZhennWang! This is one way in which DeSci comes alive. Many more to come. @RHubJournal @ResearchHub @ResearchHubF @researchsquare researchsquare.com/article/r…

Today in @ScienceTM, we report the use of in vivo adenine base editing to correct a variant causing Dravet syndrome, a severe childhood epilepsy and neurodevelopmental disorder, substantially ameliorating disease symptoms and extending lifespan in an animal model. 1/13 drive.google.com/file/d/12rc…

Where, exactly, does learning happen in the brain? Out now @Nature , we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster, but at a cost.🧵 #neuroscience nature.com/articles/s41586-0… Open link: rdcu.be/fiyrS

🎉Please join us in congratulating Dr. Alberto Corona on receiving the 2026 #FriedmanBrainInstitute Postdoc Innovator Award. The #KennyLab's @Mr_Beto_Corona is an extraordinarily rigorous young neuroscientist whose work is among the most innovative & compelling. CONGRATULATIONS👏

1/ Excited to share that TranscriptFormer is now published in Science. We trained a generative foundation model on 112 million cells across 12 species spanning ~1.5 billion years of evolution. science.org/doi/10.1126/scie…

Delighted to have contributed to this work from the impressive lab of Dr. Ben Garcia! sciencedirect.com/science/ar…

👏PLEASE JOIN US in WELCOMING Dr. Richard Drexler as Assistant Professor in the #BrainBodyResearchInstitute, #NashNeuroscience & the #FriedmanBrainInstitute. We are thrilled that Dr. @RDrexler_ is joining us; Welcome to the lab!✨🔬

Our preprint for de novo DNA binder design is out! biorxiv.org/content/10.64898…. The punchline: methods have gotten good enough that we can find sequence specific DNA binding proteins from screening as few as 96 designs per target.

TOMORROW! On Tuesday, May 5th, 3pm, hosts @PaulKennyPhD, Dr. Ming-Ming Zhou and Dr. Mone Zaidi welcome @Yale's Dr. @CraigMCrews who will give a Special Seminar concerning one of the most exciting areas in drug discovery research today. In-Person - Hatch Auditorium. NOT TO MISS!

Nature Human Behaviour から "How to design effective scientific figures" というコメンタリーが出ました🎉参考になれば幸いです！！ nature.com/articles/s41562-0… @NatureHumBehav

🆕 review with @jp_unfried out in @NatureSMB 🧐. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? nature.com/articles/s41594-0…