Joined January 2026
- Tweets 32
- Following 37
- Followers 43
- Likes 62
2 Photos and videos
BioPrime retweeted
Just completed a drug discovery screening on @BioPrimeAI! Target: CDK4/6 - Breast Cancer | Best binding energy: -13.46 kcal/mol | Advancing science with decentralized compute. bioprime.one/results/JOB-0ff…
1
3
15
362
BioPrime retweeted
Jan 31
**Seeing such strong binding energy begets hope for impactful treatments.** w/
1
1
5
405
Feb 1
We are proud to announce TopoGrammar, a platform designed to illuminate the "dark matter" of the genome. While traditional pipelines focus on dosage, #TopoGrammar focuses on topology.
Introducing TopoGrammar: Cracking the "VUS" Code with 3D Genomics & Blockchain
68% of identified ##genomic variants are currently classified as "Variants of Uncertain Significance" (#VUS). For patients, this means a #diagnostic dead end.
The Problem: Conventional sequencing misses "balanced" structural variants, inversions and translocations that don't change gene dosage but do wreck the genome's 3D regulatory architecture.
The Solution: #TopoGrammar treats chromatin organization as a structured language. By modeling enhancers and promoters as "grammatical sentences," we identify disruptions that others miss.
The Tech:🧬 PINNs: Physics-informed neural networks for high-fidelity 3D reconstruction. 🎯
- CTCF-Gating: 91% boundary detection accuracy (outperforming HiCCUPS). ⛓️ #Blockchain
- Attestation: Every result is hashed to the #BSV blockchain for immutable, @US_FDA-compliant verification without exposing PHI.
The Results:• 68% VUS reclassification rate. • 93% pathogenic accuracy. • Seamless integration with @BioPrimeAI v4.0 for genome-to-drug workflows.
Stop guessing on VUS. Start decoding the #3Dgenome.
🔗 Try the Live Demo: huggingface.co/spaces/GotTha…
@SmartLedgerTech @bioprimeai @Sdot2121 @Codenlighten1 @jalexanderm @grok
#Genomics #PrecisionMedicine #AI #Biotech
1
1
2
70
BioPrime retweeted
4
13
1,137
Jan 28
BioPrime's sponsor community is making history. @jalexanderm leading breast #cancer #research. @SmartLedgerTech, @OriginNeuralAI, @BWDaugherty, @Codenlighten1 & @Sdot2121 backing 10 disease targets from #Alzheimer's to #tuberculosis. 6.3M compounds screened. DeSCI ♥️
1
1
10
712
Jan 28
BioPrime live stats: 6.3M compounds screened, 18 jobs completed, 28 users, 62.9s avg completion time. Every job coordinated on BSV—micropayments, result verification, data provenance, fractionalization. This is what production infrastructure looks like in drug discovery. 🧬⛓️
2
4
178
Jan 28
Drug discovery demands immutable #data provenance.
BioPrime uses #BSV (@SmartLedgerTech) to timestamp every docking result, ensuring #research integrity from compound screening to publication.
When lives depend on your data, you don't compromise on #blockchain capacity.
2
29
Jan 28
Yes 🙌
Jan 28
This is amazing ❤️ and needs more awareness! From women across the globe, let me say, thank you @jalexanderm and @BioPrimeAI!
What an amazing opportunity!
2
24
Jan 28
"Finding cures shouldn't be locked behind pharma
boardrooms."
@jalexandermartin just became our sole Breast
Cancer Research sponsor - and he's giving $5 to
every new citizen scientist who joins.
1 million compounds. Free.
🎀 bioprime.one
3
5
650
Jan 28
🔬 BioPrime Engine Deep Dive
We're live-benchmarking our improved docking algorithms:
📈 Results so far:
• 16% better RMSD (closer to crystal structure)
• Testing: HIV protease, kinases, GPCRs
• 200 poses × 100 GD steps × 30 ILS iterations
1
2
27
Jan 28
⚡️ Enhancements:
• Grid-based sampling
• Adaptive parameters
• Multi-start optimization
Goal: Match Vina's 70% success rate on blockchain rails.
This is the future of #DeSci 🧬🔗
#Biotech #DrugDiscovery #Web3
2
18
Jan 26
Same optimization engine powering BioPrime's 10,000x drug discovery speedup.
OriginNode proves it in blockchain.
BioPrime proves it in molecular docking.
Production-validated.
42.9% improvement under adversarial conditions speaks louder than any whitepaper. 🧬
Blockchain node that gets BETTER under attack?
Just verified OriginNode:
- 42.9% improvement under stress
- 3.85s to complete
- Immutable BSV proof
whatsonchain.com/tx/57b1cea8…
The Daugherty Engine is real. #BSV
2
74
Jan 26
Breaking: Every new @BioPrimeAI account now gets $5 free credit.
That's 1 million compounds screened. For free. No payment required.
Just sign up and start your #drugdiscovery campaign.
We're serious about democratizing science.
bioprime.one
1
5
10
1,087
Jan 26
Why we're doing this:
Traditional molecular docking: $50K per screen
BioPrime: $5 per million compounds
But even $5 could be a barrier for students, researchers in developing countries, or anyone just starting out.
So now your first million compounds are on us.
1
5
80
Jan 26
Researchers: No more excuses.
• No payment required
• No waitlist
• No approval process
• $5 free credit = 1M compounds
Pick your disease target. Upload your compounds. Run your screen.
Starting right now.
bioprime.one
4
66
Jan 26
11 diseases. Multiple research teams. One platform.
Individual researchers can now run campaigns that used to require pharma-level budgets.
@SmartLedgerTech, @OriginNeural #AI, and #community contributors all screening simultaneously.
Drug discovery is open. 🧬
@elonmusk
The Daugherty Engine is not theory, its completing real drug discovery screenings on a single @NVIDIA powered GPU: 10,000x faster.
@BioPrimeAI is running live campaigns on:
• Breast Cancer (CDK4/6)
• Melanoma (BRAF V600E)
• Type 2 Diabetes (DPP-4)
• HIV-1 Protease
• Lung Cancer (EGFR, ALK)
• Tuberculosis (InhA)
• Alzheimer's (AChE)
• Parkinson's (MAO-B)
• Dengue NS3
• COVID-19 Mpro
100K compounds screened. 21 candidates found. 24 hours.
6 seconds/$5 vs weeks/$50K.
bioprime.one
1
5
165
Jan 26
🧬 Day One: DELIVERED.
16 molecular docking jobs complete
100,000 compounds screened
21 drug candidates identified
This is what democratized drug discovery looks like.
Full report from @BWDaugherty 👇
x.com/BWDaugherty/status/201…
2
4
289
Jan 26
Verified: Daugherty Engine solving 1M variable Ising problems - 178x larger than D-Wave quantum computers! 🔬 #Optimization #QuantumAdvantage 1millionspins.originneural.a…
1
21