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ALT Differential requirements of sphingoid-base and fatty acid hydroxylation for cell growth, size homeostasis, and TORC2 signaling. (A) Analysis of cell growth. WT, sur2Δ, scs7Δ, and double-mutant sur2Δ scs7Δ strains were grown to exponential phase, and tenfold serial dilutions were spotted onto rich (YPD) or poor (YPG/E) media plates. Plates were incubated at the indicated temperatures (25°C, 30°C and 37°C) for 2–3 days.
ALT José Ignacio Quesada Márquez
ALT Optimisation of the zebrafish frailty index. (C,D) Frailty scoring of 60 old robust, pre-frail and frail old female (C) and male (D) zebrafish by zebrafish experts compared to the optimised frailty index with weighting and the original frailty index proposed in Table 2. Simple linear regression, n=30.
ALT Anne Cathrine Hyde
ALT Fast & Fair peer review. A new initiative offering high-quality peer review within 7 working days of submission.
ALT Workshop: Rethinking Cell Differentiation and Development: A Unicellular Perspective Organisers: Elena Casacuberta and James Gahan Date: 6 – 9 December 2026 Venue: Buxted Park, East Sussex, UK
ALT Intracellular distribution of the Vps10Δ/Vps68 CT chimera in different sorting nexin and retromer mutants. Plasmid pRK2075, expressing the Vps10Δ reporter with the Vps68 C-terminus, was transformed into different strains. From top to bottom: BY4741 (WT), Y01654 (Δsnx3), Y01386 (Δsnx4), RKY2074 (Δvps35), Y06533 (Δmvp1). From left to right: sfGFP staining, DIC picture, merged picture.
ALT The Tmem43p.S333L knock-in line exhibits morphological defects in mitochondria. (A) Representative TEM images of body wall musculature from control Drosophila samples (Tmem43wt). (A′–A″″) Different orientations and close-ups of individual mitochondria are shown (insets). (B) Representative TEM images of body wall musculature from transgenic Tmem43p.S333L knock-in Drosophila samples. (B′–B″″) Different orientations and close-ups of individual mitochondria are shown (insets).
ALT Co-localization and interaction of endogenous WWP1 and WBP2 in human heart. Endogenous co-localization of a subset of cellular WWP1 (purple) and of WBP2 (green) in paraffin sections of human ventricles by co-immunofluorescence (A). Nuclei were counterstained with DAPI (blue). Signal overlap was detected in puncta beneath the sarcolemma (white arrowheads). Scale bars: 10 µm. To determine whether there might be endogenous interaction between the proteins, PLA was performed on two independent sources of cardiac tissue.
ALT Fast & Fair peer review. A new initiative offering high-quality peer review within 7 working days of submission.
ALT Fast & Fair peer review. A new initiative offering high-quality peer review within 7 working days of submission.
ALT Advert for BiO Global South travel grants, deadline 19 June 2026, with audience photo and a Biology Open logo