Brian, for the love of god, you cannot take a health database, click 'sort' and think that the top 5 drugs patients who survive longer happen to be taking are causal to the benefit those patients received. 500k is actually not a large cohort for a database, needs alpha correction, was very unlikely to be prespecified, etc. that's why no one is impressed with these studies and they're published in trash journals. this study showed a slight increase in CV events with PDEs vs placebo pubmed.ncbi.nlm.nih.gov/1452… the mechanistic rationale is not there and your explanation is terrible. ALL PDEs metabolize cAMP/cGMP, thats why they are phosphodiesterases. are you suggesting we should inhibit all PDEs?! by the same logic we should all be taking ERAs too. why not ARBs and ACEs? screw it i'll take inhaled treprostinil too. might extend my life. then i'll run SQL queries on health databases until i see a 'signal', bonferroni may roll in his grave but i will be vasodilated.

One of the reasons this market feels so directionless is because we’re stuck between two major cost basis clusters. The deep value zone sits around $49K-$54K. The fair value and participant cost basis cluster sits around $73K-$93K. We’re currently in the gap between them. No man’s land.

NEW: Amazon researchers are reportedly behind the jailbreak report that led to the U.S. crackdown on Anthropic’s top models.

I can’t believe Anthropic comparing their product to nuclear weapons 800 times backfired on them. I am shocked

I take Cialis, but not for sex. It’s actually a longevity medicine. Cialis (Tadalafil) is great for the same reason it gives you fantastic erections… it improves blood flow. Studies show that Tadalafil… 34% reduced all-cause mortality 27% reduced major heart disease 34% reduced stroke 32% reduced dementia It has also shown benefit in insulin sensitivity, metabolic health, and reduction of body fat. Women have blood vessels too, so theoretically they'd get the same longevity upside. The research is thinner, but early signals are promising. It’s sad that when men and women could benefit from it can miss out because it’s taboo. My protocol is 5mg daily and I've been on it for about two years. *Observational research shows associations, not causation. Outcomes may be influenced by underlying differences in study populations. This is not medical advice and is shared for informational purposes only.

Top 10 Public Bitcoin Treasury Companies 1. @Strategy - 845,256 2. @twentyone - 43,514 3. @Metaplanet - 40,177 4.@MARA - 35,303 5. Bitcoin Standard Treasury Co - 30,021 6. @Bullish - 24,300 7. @Strive - 19,032 8.@SpaceX - 18,712 9. @coinbase - 16,492 10. @RiotPlatforms - 15,680

The sheer scale of a trillion dollars can be hard to comprehend. Let me put it in perspective. You would have to earn a dollar a year for a trillion years straight to have that much money.

Children derail academic careers even in places with good social nets, like Denmark

Reddit moment.

No, you don't get it. He does not have $1 trillion sitting in cash, it is 99% stock in his companies. To make that wealth liquid would mean selling all that stock which would swiftly destroy *both* the companies (Tesla, SpaceX, others) and the wealth. If he sold it all, he'd end up with maybe $100b max, several hundred thousand people would be out of work, the companies ruined and many of their suppliers also ruined. Okay, but now Elon has $100b in cash, and can "solve the world's problems". $100b divided by the world's 8 billion people is $12 If you were in charge, several of the most innovative industrial companies in the world would be destroyed, hundreds of thousands out of work, and space would again close to human civilization for another generation. But everyone on earth could have one nice meal and you could revel in your altruism.