Joined May 2017
- Tweets 4,179
- Following 505
- Followers 2,754
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537 Photos and videos
Pinned Tweet
6 Mar 2025
We just released the largest amount of stress profiling data from our (any?) lab so far!
How does the molecular stress response adapt as an acute stressor becomes chronic?
Multiomic profiling in the 🐭 hippocampus, led by @RebeccaWaag and co-last author Pierre-Luc Germain! 💪
5 Mar 2025
Distinct molecular mechanisms of stress habituation in the mouse hippocampus biorxiv.org/content/10.1101/… #biorxiv_neursci
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Johannes Bohacek retweeted
Jan 19
Yes, but the suprising detail is that the population pattern of activation by norepinephrine did not correlate with the population pattern of activation arousal (which is thought to be mediated by norepinephrine for astrocytes).
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Johannes Bohacek retweeted
Jan 19
Very excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with Sian Duss @BohacekLab, and many others: biorxiv.org/content/10.64898… 1/5
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How does your favorite gene respond to stress? Check out our updated “Stressome-app”!
In a new @NatureComms paper we extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress.
nature.com/articles/s41467-0…
👇
bsky.app/profile/bohaceklab.…
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Johannes Bohacek retweeted
22 Oct 2025
6/ But is ELS always like this?
We mapped each mouse into a behavioral similarity space (@BohacekLab), with a behavioral score of how ELS or control-like each animal behaved. About 30% of ELS mice looked like controls with richer, flexible repertoires: resilient individuals?
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Johannes Bohacek retweeted
31 Mar 2025
Our study describing a role for the circular RNA circRERE in the regulation of silent excitatory synapses is finally out @NatureComms! nature.com/articles/s41467-0…
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16 Mar 2025
Stellar women-only (💪) panel on stress and development, loaded with cutting-edge multiomic data kicking off the European Stress Conference #ESC2025 in Innsbruck, Austria
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11 Mar 2025
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit (in line with recent work from others, see refs in our preprint):
biorxiv.org/content/10.1101/…
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11 Mar 2025
Note: Modest grimace pain levels remain detectable for 24hrs after surgery. Neither meloxicam (5mg/kg) nor the combination of meloxicam(5mg/kg) buprenorphine(0.1mg/kg) could eliminate these remaining pain levels.
We detect strong side-effects from opioid treatment (hyperactive).
ALT Mouse face image collected from the GrimACE device, showing bilateral cannula implant 24hrs after surgery. Expert and machine learning agent detect transient pain levels that are managed equally well by meloxicam-only or meloxicam buprenorphine.
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11 Mar 2025
Most importantly: We developed an automated, portable pain and welfare monitoring system (combining "mouse grimace scale" and full-body pose-estimation with behavior flow analysis).
Brilliant work by @osturmscience, the @ETH_en 3R-Hub and our collaborator Katharina Hohlbaum. 💪
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6 Mar 2025
We just released the largest amount of stress profiling data from our (any?) lab so far!
How does the molecular stress response adapt as an acute stressor becomes chronic?
Multiomic profiling in the 🐭 hippocampus, led by @RebeccaWaag and co-last author Pierre-Luc Germain! 💪
5 Mar 2025
Distinct molecular mechanisms of stress habituation in the mouse hippocampus biorxiv.org/content/10.1101/… #biorxiv_neursci
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6 Mar 2025
On a single-cell level, we reveal blunted chromatin accessibility changes after chronic stress for cAMP signaling, and a damped response that returns to baseline much faster for glucocorticoid receptor binding. This again points to two parallel mechanisms of habituation.
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6 Mar 2025
And saving the best for last: We integrate these results with previously published bulk and single-cell data from our lab and make these data freely accessible and searchable through an interactive app (ethz-ins.org/stressome2). We hope people like this resource - please RT! 🙏
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Johannes Bohacek retweeted
31 Dec 2024
With best wishes for 2025, I bid farewell to this communication channel. I am following various colleagues from the university world and industry who have withdrawn from X in recent months.
Feel free to follow the official social media channels of @ETH_en. Happy New Year to all!
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Johannes Bohacek retweeted
5 Dec 2024
At its meeting on December 5, 2024, the ETH Board appointed nine professors at the request of ETH President Joël Mesot. In addition, the title "Professor" was awarded twice.
brnw.ch/21wPdmB
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30 Nov 2024
Cool! Congrats, @lustenca !
27 Nov 2024
Sleep problems have become a widespread issue. In a new popular science book and in an interview with ETH News, ETH sleep researcher Caroline Lustenberger describes the do’s (and don’ts) for when you can’t get to #Sleep. ethz.ch/en/news-and-events/e…
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