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Bone & Joint Research @BoneJointRes

A Gold open access orthopaedics and musculoskeletal research journal edited by Ms Chloe E. H. Scott and published by Bone & Joint. Impact factor: 5.1.

Joined May 2012
  • Tweets 7,937
  • Following 1,282
  • Followers 19,077
3,503 Photos and videos
This week’s research spotlight is on the morphological traits of flexion varus tibial plateau fractures and the related soft-tissue injuries such as ligament and meniscus damage. Check out the full episode below! #Podcast #AITalks #Fracture ow.ly/lhhV50Z9oiy
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The present retrospective cohort study analyzed direct and indirect costs and length of hospital stay, number of surgical procedures, and hospital (re-)admissions of nonunion patients. #BJR #Fracture #Healthcare #Orthopedics #Surgery ow.ly/g3OI50Z8X1a
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"... high reoperation rates & generally unfavorable outcomes". 🦵 This week, we discuss a comprehensive study with findings that have the potential to improve preoperative evaluations & allow for more tailored surgical approaches. Tune in below! #Ortho ow.ly/hcY650Z9XkU
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Metaphyseal cones provide adequate biomechanical stability for tibial plateau fractures in osteoporotic bone. #Fracture #Biomechanics #Trauma #BJR ow.ly/evwU50Z8Qok
Image depicts tibial implant configuration and defect modelling.

ALT Image depicts tibial implant configuration and defect modelling.
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The aim of this study is to examine how eukaryotic translation initiation factor 5A regulates osteoarthritis during mechanical overload and the specific mechanism. #BJR #Athritis #Research #OpenAccess ow.ly/HmlU50Z8X5h
Diagram depicts model of the specific mechanisms by which eukaryotic translation initiation factor 5A (eIF5A) regulates chondrocyte homeostasis under mechanical loading.

ALT Diagram depicts model of the specific mechanisms by which eukaryotic translation initiation factor 5A (eIF5A) regulates chondrocyte homeostasis under mechanical loading.

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The most commonly reported design characteristics include titanium as the primary material, lattice structures to promote bone ingrowth or accommodate bone grafts, and fixation via plates, nails, stems, or hybrid combinations. #Patients #Surgery #BJR ow.ly/Nc3j50Z8Qep
Image depicts classification examples of nine different types of custom implant.

ALT Image depicts classification examples of nine different types of custom implant.
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"... using machine learning to automate a vital part of diagnosing periprosthetic joint infections". 🔎 Tune in to the latest #AITalks episode below, highlighting an important step toward integrating machine learning into pathology! #AI #Ortho #Research ow.ly/HKNV50Z9Vbn
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High doses of sclerostin increase bone resorption, alter osseous microarchitecture & promote osteoclastogenesis. Sclerostin also induces trabecularization of cortical bone, triggering the development of osteocytic osteolysis. #BJR #Bone #Biology #FOAMed ow.ly/ET4o50Z8WQc
Bone & Joint Research. Abstract text for article titled 'Impact of elevated sclerostin levels on bone resorption'.

ALT Bone & Joint Research. Abstract text for article titled 'Impact of elevated sclerostin levels on bone resorption'.
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Bone & Joint Research retweeted
Hao Yin
@HaoYin20
Jun 9
FGF9 #OsteoArthritis Adenoviral FGF9 (intra-articular injection) alleviate mouse OA (destabilization of medial meniscus) Anti-senescent effects of exosomes from FGF9-overexpressing chondrocytes A possible role of NRF2-GPX3 axis "primary chondrocytes isolated from 195 OA patients over the past decade" @BoneJointRes 2026 boneandjoint.org.uk/Article/…
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Podcast out now! 🎧 This week's discussion focuses on a recent paper exploring a computer model trained on public datasets with supervised methods to count neutrophils in whole slide histology images to aid the diagnosis of #PJI. Listen below! #AITalks ow.ly/RJf050Z9mjH
AI Talks with Bone & Joint Research. Diagnosing orthopaedic infection by identifying neutrophils in whole histology slide images with machine learning trained on publicly available datasets. Bentick et al. Bone Joint Res. 2026;15(3):238-247. Image of histology slide in background.

ALT AI Talks with Bone & Joint Research. Diagnosing orthopaedic infection by identifying neutrophils in whole histology slide images with machine learning trained on publicly available datasets. Bentick et al. Bone Joint Res. 2026;15(3):238-247. Image of histology slide in background.
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We define the FGF9/NRF2/GPX3 axis as a key regulator in osteoarthritis chondrocyte pathogenesis and propose adenoviral FGF9 and FGF9-enriched exosomes as promising therapeutic strategies. #Arthritis #Trauma #Research #FOAMed #BJR ow.ly/LHvS50Z8PMP
Image depicts schematic summary of the proposed fibroblast growth factor 9 (FGF9)-mediated mechanism in osteoarthritis (OA) and its therapeutic potential.

ALT Image depicts schematic summary of the proposed fibroblast growth factor 9 (FGF9)-mediated mechanism in osteoarthritis (OA) and its therapeutic potential.
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Bone & Joint Research retweeted
The Bone & Joint Journal@BoneJointJ
Jun 5
📚 Learn Mode |⌛Exam Mode Whether you want to drill questions in Exam Mode or slow down and study reasoning in Learn Mode, you can practise for your orthopaedic qualifying exams your way on BJJ LIFE. Start your free trial today! #FRCS #Orthopedics boneandjoint.org.uk/life/
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Autologous osteoperiosteal graft outperformed conventional bone graft shelf acetabuloplasty in a rabbit DDH model, suggesting its potential as a superior clinical option for DDH treatment during endoscopic shelf acetabuloplasty surgery. #BJR #Hip #FOAMed ow.ly/e8JS50Z7eiN
Bone & Joint Research. Abstract text for article titled 'Autologous osteoperiosteal graft shows superior outcomes to bone graft in shelf acetabuloplasty for acetabular dysplasia'.

ALT Bone & Joint Research. Abstract text for article titled 'Autologous osteoperiosteal graft shows superior outcomes to bone graft in shelf acetabuloplasty for acetabular dysplasia'.
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This article provides a brief and practical introduction to commonly used state-of-the-art methods, as well as some ‘classic’ methods, to measure different outcome metrics during in vitro mechanical testing. #Orthopedics #Ortho #OrthoResearch ow.ly/qrXl50Z6ynX
Mechanical testing methods for orthopaedic research. a) Diagram of typical in vitro measurements on any bone, joint, cartilage, soft tissue, or implant.

ALT Mechanical testing methods for orthopaedic research. a) Diagram of typical in vitro measurements on any bone, joint, cartilage, soft tissue, or implant.
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Growth differentiation factor 15 (GDF-15) levels are elevated in the serum of rheumatoid arthritis (RA) patients and increase with the severity of disease activity, demonstrating the potential of GDF-15 to predict RA activity. #BJR #Arthritis #Patients ow.ly/TRRg50Z5jFg
Systematic review exploring growth differentiation factor 15 as a diagnostic biomarker for rheumatoid arthritis activity and severity.

ALT Systematic review exploring growth differentiation factor 15 as a diagnostic biomarker for rheumatoid arthritis activity and severity.
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This study quantifies time- and position-dependent peracute responses of cartilage redox balance to impact injury at controlled oxygen tension. #Cartilage #Injury #Trauma #Orthopedics #BJR #OpenAccess ow.ly/3oFa50Z6c7x
Representative images of the articular surface of two impacted samples. Cracks were visualized by wiping the articular surface with India ink.

ALT Representative images of the articular surface of two impacted samples. Cracks were visualized by wiping the articular surface with India ink.

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In conclusion, in this study we demonstrated that hBMSC-Exos and hADSC-Exos have similar microRNA profiles but are largely different from hiPSC-Exos. #BJR #StemCells #Research #FOAMed ow.ly/3hkk50Z5jtC
Comparison of miRNA profiles in exosomes from human iPSCs, ADSCs, and BMSCs showing distinct expression patterns related to chondrocyte function.

ALT Comparison of miRNA profiles in exosomes from human iPSCs, ADSCs, and BMSCs showing distinct expression patterns related to chondrocyte function.
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This study investigated the cellular and molecular mechanisms by which diabetes mellitus exacerbates osteoarthritis, through multiomics analysis of synovium and cartilage from patients with both conditions. #Diabetes #Osteoarthritis #BJR #OpenAccess ow.ly/Ujt950Z6bMF
Single-cell atlas of human knee articular cartilage in patients with osteoarthritis (OA) and type 2 diabetes mellitus (T2DMOA). The t-distributed stochastic neighbour embedding (t-SNE) plot of the 11 identified main subpopulations in cartilage.

ALT Single-cell atlas of human knee articular cartilage in patients with osteoarthritis (OA) and type 2 diabetes mellitus (T2DMOA). The t-distributed stochastic neighbour embedding (t-SNE) plot of the 11 identified main subpopulations in cartilage.
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In this study we compared infection clearance and bone healing in early and delayed fracture-related infection treated with debridement, antibiotics, and implant retention in a rabbit model. #BJR #Fracture #Infection #OrthoTwitter ow.ly/hxuv50Z5jk6
Image depicts representative contact radiographs in anteroposterior and lateral view of the rabbit humerus after euthanasia, with arrows marking the osteotomy site in: a) the early group at eight weeks; b) the delayed group at 11 weeks; and c) the control group at 11 weeks.

ALT Image depicts representative contact radiographs in anteroposterior and lateral view of the rabbit humerus after euthanasia, with arrows marking the osteotomy site in: a) the early group at eight weeks; b) the delayed group at 11 weeks; and c) the control group at 11 weeks.
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This article provides an introduction to important aspects of the design process for orthopaedic implants. #BJR #OrthoTwitter #Surgery #Biomechanics ow.ly/flJf50Z5fE5
Overview of the design process for orthopaedic implants, highlighting engineering, materials, and clinical considerations for various surgical uses.

ALT Overview of the design process for orthopaedic implants, highlighting engineering, materials, and clinical considerations for various surgical uses.
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