Sharing brain research articles with today's most significant findings.
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Spatial transcriptomics revealed six serotonergic subpopulations in the dorsal raphe. Fluoxetine induced distinct acute and chronic gene-expression changes, affecting Htr1a, Ras/MAPK/cAMP signaling, axon guidance, and neuropeptides. nature.com/articles/s41380-0…
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Liraglutide exerts antidepressant effects independently of GLP-1R via a gut–brain mechanism. It increases Lactobacillus delbrueckii, restores endocannabinoid 2-AG levels, normalizes neuronal activity, and alleviates depression-like behaviors. cell.com/cell-host-microbe/f…
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Home alone: Remote work, isolation, and mental health | Science science.org/doi/10.1126/scie…
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Spatial transcriptomics identified six serotonergic subpopulations in the dorsal raphe nucleus and revealed acute/chronic fluoxetine-induced gene changes, including Htr1a regulation, signaling pathways, and neuropeptide expression. nature.com/articles/s41380-0…
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Young brains preserved memory after AβO exposure, whereas aging brains showed reduced resilience. Age and AβO exerted additive and region-specific synergistic effects, highlighting the importance of aging in preclinical AD models. link.springer.com/article/10…
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Sleep may have a unique role in vascular brain health and dementia risk alz-journals.onlinelibrary.w…
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Researching the Brain retweeted
The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
elifesciences.org/articles/1…
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The oscillatory biology of sleep: Linkage to dementia | Science science.org/doi/10.1126/scie…
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A genetic tracing system reveals compartmentalized brain protein-clearance routes to CSF and border tissues. Drainage follows a “nearest exit” rule, while inflammation and amyloid pathology disrupt clearance through distinct mechanisms. cell.com/cell/fulltext/S0092…
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Plasma-based staging may provide a scalable, minimally invasive approach to biological stratification of Alzheimer disease, with potential value for treatment selection and clinical trial enrichment. jamanetwork.com/journals/jam…
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An optogenetic model of accelerated TMS-like stimulation produced rapid antidepressant effects by enhancing prefrontal synaptic plasticity and activating a fronto-insular circuit. Human EEG/fMRI data confirmed this network as a key mediator. cell.com/cell/abstract/S0092…
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Direct recordings from the human thalamus revealed a novel 19–45 Hz oscillation present only during wakefulness and REM sleep. This signal, localized to the central thalamus, tracks REM microstates and may help regulate conscious brain states. nature.com/articles/s41562-0…
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Researching the Brain retweeted
This retrospective study found that adult status epilepticus mortality has risen over 2 decades, highest in elderly and non-Hispanic Black adults: hubs.la/Q04jd1ZX0
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Recent studies have revealed the synchronization of neuromodulators including norepinephrine, serotonin, acetylcholine, dopamine, and histamine during sleep.
A new #ScienceReview explores what potential role the synchronization of these oscillations may play in health. scim.ag/4ve9ObR
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Researchers identified inhibitory neurons linking the Rostral Ventromedial Medulla to the spinal cord that mediate “pain-inhibits-pain” effects, suppress widespread pain sensitivity, and may malfunction in chronic pain syndromes. nature.com/articles/s41467-0…
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Neuroligin-2 is essential for inhibitory plasticity in the hippocampus and its consolidation after induction. Disrupting neuroligin-2 erases inhibitory, but not excitatory, plasticity, with implications for epilepsy, autism, and schizophrenia. jneurosci.org/content/46/16/…
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Acute stress impairs memory integration and flexible inference by reducing hippocampal reactivation during new learning and promoting differentiation of overlapping memories into discrete representations. science.org/doi/10.1126/scia…
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Researching the Brain retweeted
Dual orexin receptor antagonism with lemborexant enhances #microglial clearance of β-#amyloid in mice
Ashish Sharma, Emiko Segawa, Xiaoying Chen...Erik S. Musiek @ErikMusiek @washumedicine #Sleep #AlzheimersDisease
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A biologically plausible model learned reward-specific values and state representations simultaneously via feedback alignment. Inhibition dominance was essential; excess excitation impaired learning, resembling schizophrenia-related symptoms. jneurosci.org/content/46/16/…
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In matched older adult cohorts, Aβ and tau biomarkers correlated with cognition in ADNI clinic participants but not in community-based U.S. POINTER subjects, suggesting reduced biomarker-cognition associations in real-world populations. alz-journals.onlinelibrary.w…
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