Chief Medical Officer, Miami Transplant Institute, @JacksonHealth, portal HTN, IR/hep, disparities, vascular liver disease/ opinions mine alone
Joined November 2019
- Tweets 3,503
- Following 2,149
- Followers 2,586
- Likes 17,843
101 Photos and videos
Brett E Fortune MD retweeted
Jun 11
As #liverdisease rates continue to rise, the need for earlier detection and coordinated care is more urgent than ever.
AASLD’s new Liver Care for Frontline Clinicians program equips primary care and other non-specialty healthcare professionals with practical, evidence-based resources to improve liver disease outcomes. #WorldMASHDay #FattyLiverDay
Learn more: bit.ly/4xsX9ni
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Brett E Fortune MD retweeted
Jun 10
🔥 HOT TOPIC
📗 @HEP_Journal
Potentially practice-changing for patients with #MASLD and #type2diabetes, this study found that a #GLP-1 receptor agonist–SGLT-2 inhibitor combination was associated with a lower risk of major adverse liver and cardiovascular outcomes compared with either therapy alone.
The study also highlights an innovative use of emulation trial methodology to evaluate potential clinical efficacy in the absence of prospective randomized trials.
Read the article here ➡️ bit.ly/4e9OME9
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Brett E Fortune MD retweeted
Jun 6
🎉 Join us in celebrating the #AASLD 2026 Distinguished Award recipients!
Learn more about their remarkable contributions and accomplishments in #hepatology: bit.ly/4vzuhrN
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Efficacy and Safety of Carvedilol in Cirrhosis Patients... : Official journal of the American College of Gastroenterology | ACG journals.lww.com/ajg/abstrac…
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Barriers and Facilitators of Alcohol Use Disorder Treatment ... : Official journal of the American College of Gastroenterology | ACG journals.lww.com/ajg/fulltex…
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Brett E Fortune MD retweeted
Need to encourage more high quality liver transplant research @EASLedu #EASLcongress. It’s the reason many hepatologists went into their field of medicine
May 30
⏬Download the Best of #EASLCongress Slide Decks on #EASLCampus!
These editable Slide Decks bring together the top selected abstracts from the Congress in each topic track. 📚
🔗easlcampus.eu/Documents/best…
@EASLNews @CornbergMarkus @JasmohanBajaj @hlcortezpinto @Alexfornergon @horstef @SilviaAffo
#LiverX #BestOf
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Brett E Fortune MD retweeted
May 30
⏬Download the Best of #EASLCongress Slide Decks on #EASLCampus!
These editable Slide Decks bring together the top selected abstracts from the Congress in each topic track. 📚
🔗easlcampus.eu/Documents/best…
@EASLNews @CornbergMarkus @JasmohanBajaj @hlcortezpinto @Alexfornergon @horstef @SilviaAffo
#LiverX #BestOf
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Brett E Fortune MD retweeted
May 28
HBV Functional cure with Bepirovirsen
B-Well 1 and B-Well 2 phase 3 studies
➡️ 24 weeks of Bepi s/c q1 week
(all on NUCs)
~19% if qHBsAg <3000
~26% if qHBsAg <1000
#EASL2026 #IDxposts
Presented at #EASL:
In two phase 3 trials, 19% of patients with chronic hepatitis B infection had a functional cure with the antisense oligonucleotide bepirovirsen, 24 weeks after stopping all HBV treatment; functional cure was not seen with placebo. Full results of the B-Well 1 and B-Well 2 trials: nej.md/4fKe9ib
Editorial: A Major Step toward a Cure for Hepatitis B Infection nej.md/4o31etZ]
@EASLnews
ALT Graphs illustrating study outcomes for bepirovirsen versus placebo. Graph A presents the primary outcome for patients with baseline HBsAg levels <3000 IU/ml. Graph B illustrates the key secondary outcome for patients with baseline HBsAg levels <1000 IU/ml. Both graphs indicate p-values <0.001.
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Brett E Fortune MD retweeted
🧫 Post-TIPS heart failure (EuroTIPS)
🗣️ @anna_baiges | #EASLCongress
🔬 HF in 11% — Toulouse algorithm ❌ fails in real-world
🆕 EuroTIPS HF score (NT-proBNP, MetSyn, Na⁺, sex) → high risk 45% vs 3% (validated n=824)
⚠️ Check cardiac biomarkers BEFORE TIPS!
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Brett E Fortune MD retweeted
📜 Preemptive TIPS — Baveno VIII
🗣️ M. Rudler | #EASLCongress
🔬 72h 🪟 is open! Up to 14 d CPC / 7 d CPB — no MELD futility cut-off
💡 pTIPS preferred in AVB from GOV2/IGV1
🍺 Severe AH: No futility criteria if pTIPS criteria met
🧠 Consider LT in refractory OHE after pTIPS
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Brett E Fortune MD retweeted
🧫 CKD predicts worse outcomes after TIPS for ascites
🗣️ @luistevilla | #EASLCongress
Key results (EuroTIPS cohort, n=653):
🔬 CKD → ↑ mortality (aHR 2.26) & ↑ persistent ascites (aRR 3.35)
⚠️ MASH CKD = extreme risk: aRR 7.06!
💡 Screen for CKD before TIPS
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Brett E Fortune MD retweeted
🧫 Ongoing Phase III RCTs in ascites & HRS
🗣️ C. Ripoll | #EASLCongress
🔬 Ongoing trials:
- Ascites → ALBTRIAL | eTIPS (early TIPS vs SOC)
- HRS-AKI → Ambrisentan/ET-A antagonist | OCE-205 | Liver-HERO (TIPS)
- SGLT-2 inhibitors also under investigation
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Brett E Fortune MD retweeted
🧫 Infection & HE in cirrhosis
🗣️ T. Thévenot | #EASLCongress
🔬 Rifaximin & cotrimoxazole (ASEPTIC trial) for 1 PF SBP prophylaxis → no benefit — Baveno VIII agrees
⚠️ Antibiotic prophylaxis in GI bleeding also questioned in Child-Pugh A pts
💡 Future: albumin, probiotics & FMT
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Brett E Fortune MD retweeted
📜 Underdilated TIPS (≤7mm) in refractory ascites
🗣️ D. Saltini | #EASLCongress
🔬 ↓ mortality & ↓ OHE — similar ascites control
⚠️ Dilation diameter = key modifiable determinant — not hemodynamic targets
💡 Step-up strategy: start with under-dilation
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Brett E Fortune MD retweeted
🧫 Ongoing Phase III RCTs in variceal bleeding & cirrhosis
🗣️ @DTrip2015 | #EASLCongress
🔬 Ongoing trials:
- NSBB → BOPPP (carvedilol vs placebo, small varices) & CROSBY (carvedilol ± EVL)
- pTIPSS → REACT-AVB (early pTIPSS vs SOC)
- APEACH (apixaban) | SACRED (simvastatin)
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Brett E Fortune MD retweeted
🧫 New multisociety consensus on PSVD
🗣️ L. Elkrief | #EASLCongress
🔬 PSVD & NCPF now interchangeable
⚠️ Biopsy mandatory | can be diagnosed WITHOUT portal hypertension
💡 First globally endorsed framework (EASL/AASLD/APASL/ALEH)
🔗 journal-of-hepatology.eu/art…
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Brett E Fortune MD retweeted
📜 Preventing decompensation in cACLD — Baveno VIII 🗣️ @bogdanprocopet | #EASLCongress
🔬 PH = main driver of decompensation
⚠️ Ascites = most common & deadliest event
💡 Treat the etiology → ↓PH → ↓decompensation risk
💊 NSBBs (carvedilol) → ↓ decompensation (ascites)
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Brett E Fortune MD retweeted
📜 Anticoagulation for PVT in cirrhosis
🗣️ N. Riva |
💡 Treat based on: LT candidacy, thrombus extension & cirrhosis severity
🔬 DOACs in cirrhosis:
✅ Child A → all DOACs OK
⚠️ Child B → apixaban/edoxaban with caution, avoid rivaroxaban
❌ Child C → avoid all DOACs
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Brett E Fortune MD retweeted
#CGH4ALL @AGA_CGH 📣
⚠️Cardiometabolic risk factors have additive impact on mortality in MASLD 📈💥
The cardiometabolic profile may matter as much as the liver itself 🧠🫀
#MASLD #MASH #LiverTwitter #Hepatology
Find out more at 👇
🔗doi.org/10.1016/j.cgh.2025.0…
Reported by @talal_khurshid
@norahterrault @juanpabloarab @RichSterlingMD @ajay_duseja @NoureddinMD @SanjayaSatapath @AlinaAllenMD @norahterrault @ArunJSanyalVCU @BrettEFortuneMD @Dr_Vijay_Shah @DougSimonetto @AlinaAllenMD @AlkhouriNaim @mqkMD @scottisaacsmd @serperm @nadimmahmud
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Brett E Fortune MD retweeted
📜 NITs: How thresholds redefine prognostication
🗣️ @docberza
🔬 Tailored NITs for CLD risk stratification
⚠️ Binary cut-offs lose prognostic info
💡 Risk modelling → individualized estimates per etiology
📈 Longitudinal NITs refine risk stratification
#EASLCongress
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