We’re feeling a little lonely up here in Chatsworth :) Some of you slackers need to open a factory nearby.

15,986,000 VIEWERS 🤯 Last night's U.S.-Paraguay game was the MOST watched @USMNT game ever on U.S English language television. AND it was the second most watched FIFA Men's World Cup game ever. EVER. We are a soccer nation.

👀 @TheFoundryTeam

This has quietly been a miracle month in medicine. In the last 5 weeks we’ve got news on: - retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels - RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life - small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol - Mayo’s AI-assisted radiology showing vastly improved cancer detection - this new therapy for metastatic solid tumors This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

Was trying to catch up with Ricky Medina from AnySignal at El Segundo Tech Breakfast Club but then Jacques Sisteron (Upfront VC) crashed the conversation If you're a founder and considering setting up shop in El Segundo - get it touch. Everywhere else in California is red tape. In El Segundo it's the red carpet

Coming soon to El Segundo!

X is shutting down Communities on May 6. I just reserved my spot in the new home for #buildinpublic. Come with me: buildinpublic.com/?ref=Brice

California has increased spending by 75% in six years. Are your bills 75% cheaper? Are our schools 75% better? No. Because the problem isn’t how much we spend — it’s how we spend it. And I’ll only spend taxpayer dollars on policies that actually make people’s lives better. Plan out tomorrow. Thanks for the conversation @friedberg!

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🚨 DIABETES CURE… OR THE BEGINNING OF A MEDICAL REVOLUTION? For over a century, diabetes has meant daily injections, constant monitoring, and a lifetime of management. But now, scientists in China and researchers at Vertex Pharmaceuticals in the United States have done something shocking, they used stem cells to create new insulin-producing cells and transplanted them into real patients. And here’s the twist… Some people with Type 1 diabetes started making their own insulin again. No pump. No syringe. Just living cells doing their job. It’s not a full cure yet. Trials are still small, and long-term results are unknown. But for the first time, medicine isn’t just managing diabetes, it’s trying to rebuild the pancreas itself. Science fiction? Not anymore..

Midterm messaging.

Wait… There’s an API for x that doesn’t suck? 🤔

New Engineering blog: We tasked Opus 4.6 using agent teams to build a C compiler. Then we (mostly) walked away. Two weeks later, it worked on the Linux kernel. Here's what it taught us about the future of autonomous software development. Read more: anthropic.com/engineering/bu…

Expanding our manufacturing footprint right here in LA 😍

Glaring hole in the product lineup for a family size vehicle 6-7 seater that fits real humans.

Mood: Intrigued

Cool to see a creator admit when things don’t work out. (And target why) Waiting for these show ratings to rollout must be painfully slow for @MrBeast given the feedback he’s used to with YouTube.

Interesting thought: Compute/Population will be how we rank the success of geopolitical systems in the future. That ratio will be the single biggest indicator of prosperity.

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China as we know it was 2 hours away from being completely flipped upside down less than a week ago. Yet we think there is going to be a post-America world with a stable China? 🤔