@BryaMatthews profile picture
Brya Matthews @BryaMatthews

Kiwi, bone biology nerd and (wannabe) traveller

Joined October 2020
  • Tweets 94
  • Following 166
  • Followers 147
6 Photos and videos
Great talk @NatalieASims. I have a question. Mice are clearly not ideal for studying coupling. What sort of models would you like to see used to better elucidate the role of these putative coupling factors in the BMU?
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View from the chairs’ table at the skeletal stem cell session this morning #ASBMR2023
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Uploaded my #vote for the NZ election from JFK airport. Love how straightforward it is to vote from overseas🙂
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Our paper looking at skeletal cell populations in adult human tissue, particularly the periosteum is out in Bone! authors.elsevier.com/sd/arti… We did a large spectral flow panel on matched samples from 21 patients and find that the periosteum looks very different overall from the BM

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Congratulations to @Ye_Cao_ for doing most of the work (and defending your thesis!!!). Thanks to @AnnaBoss100 and @DrAnnaNZ for helping get the flow panel and analysis going, and Scott, Nicola, Raewyn and the surgeons for making sure we could get plenty of hips.
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Whoops, forgot @hcmurray6 for lending your immunostaining expertise and reagents!
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And thanks to @AucklandUni library CAUL agreement the paper is open access 😃
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We also found that the CD90 CD34 population in periosteum is enriched for cells with in vitro stem/progenitor properties (CFU-F formation, clonal trilineage differentiation, tertiary colony formation)
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We think this population needs to be refined further, but looks like a good starting point for enriching for periosteal stem/progenitors in adult humans
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Articular cartilage has surprisingly high % of markers we expected to be enriched in stem cells, and performs remarkably well in CFU-F assays
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Brya Matthews retweeted
JBMRPlus@JBMRPlus
21 Jun 2023
A recent study in #JBMRPlus sought to uncover the impact of preptin KO in mice on the response to a moderately high-fat diet (HFD) and low-fat diet (LFD) @EmmaBuckels @BryaMatthews @WileyHealth #OpenAccess #ASBMR ow.ly/5WxJ50OS00C
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Excited that this work we were involved with is out in Nature Aging. This drug extends lifespan and healthspan in male and female mice. Bones didn't look so good, so more research to be done!
Peter Shepherd@ShepherdPeterR
23 Jan 2023
It’s been a long time coming but our paper showing long term beneficial effects of inhibitors targeting PIK3CA is out today. Awesome effort by Chris Hedges ⁦who did most of work and lead by ⁦@TMerry_NZ⁩ with input from many other NZ researchers. nature.com/articles/s43587-0…
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I made my exam question about avoiding the negative effects of a 'vampire lifestyle', and it makes marking so much more entertaining!
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...as the vampire life indoors is unlikely to come with a treadmill they will need to ensure strong bones from many sources such as calcium. ... my friend should practise the vampire lifestyle occasionally but ensure they are getting enough sun in between.
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...in which the vampire friend is at high risks of fractures from adopting a lifestyle that avoids sun exposure
Just received an order from Sigma that was placed in February. Don't think having to get to NZ can be an excuse for an 8 month wait!
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I started to dabble in genealogy online after visiting the Mormon ancestry center in Salt Lake City, and it turns out that King James I of Scotland was my 15ish x great grandfather!
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Brya Matthews retweeted
Dr Andrew Digby@takapodigs
13 Aug 2022
Not everything since 2016 has been bad: the #kakapo population has grown by 100% since then! 252 are alive today. #kakapo2022 #conservation Pic: Deidre Vercoe
A photo of five kākāpō chicks “begging” on a person’s hand in a hand-rearing facility, New Zealand. Credit: Deidre Vercoe

ALT A photo of five kākāpō chicks “begging” on a person’s hand in a hand-rearing facility, New Zealand. Credit: Deidre Vercoe

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Brya Matthews retweeted
Tom Wilks@tom_wilks
10 Aug 2022
Bohemian rhapsody for postdocs: Is this a real job? Or more like a PhD? Caught in short contracts No chance of stability Open your eyes Look up to PIs and see I'm just a postdoc I get no sympathy Because I'm easy come, easy go Stress is high Pay is low
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Brya Matthews retweeted
Dr Andrew Digby@takapodigs
9 Aug 2022
2️⃣5️⃣2️⃣ #kakapo! Today the youngest of this year’s chicks became a juvenile, taking the known population to the highest count ever recorded. Let’s enjoy this zenith: we expect that numbers won’t increase again until 2025. #conservation #kakapo2022 #parrots
A juvenile kākāpō on the forest floor at night.

ALT A juvenile kākāpō on the forest floor at night.

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