The ISARIC Coronovirus Clinical Characterisation Consortium is recruiting COVID-19 patients. Urgent public health research supported by @NIHRresearch @HPRUezi
Joined February 2020
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4 Photos and videos
Pinned Tweet
28 Feb 2022
Recruitment to @CCPUKstudy stops today. We hibernate now and prepare for the next exposure of Public Health Interest. Our Outbreak Data Analysis Platform is open for research with over 303k cases of #COVID19 isaric4c.net/sample_access/ @kennethbaillie @p_openshaw @ProfCalumSemple
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ISARIC4C retweeted
30 Sep 2023
Timely collation, linkage and analysis of data has been key to informing the public health and clinical response in outbreaks of MERS, COVID-19, and Childhood Acute Severe Hepatitis of Unknown Origin @CCPUKstudy @ISARIC1 #DataSavesLives
29 Sep 2023
I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research gov.uk/government/speeches/u…
The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.
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29 Sep 2023
I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research gov.uk/government/speeches/u…
The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.
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ISARIC4C retweeted
29 Sep 2023
I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research gov.uk/government/speeches/u…
The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.
27 Sep 2023
Concerns about sharing data should never be at the expense of patient care say @CMO_England @NDGoffice and @ICOnews. Their call to action encourages health and care staff to confidently and safely share data for patient care across organisations.
➡️transform.england.nhs.uk/inf…
ALT Health staff member at a desk and using a laptop
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ISARIC4C retweeted
20 Sep 2023
In general, the impact of Covid-19 on causing critical illness, i.e needing intensive care, in children lessened over the first two years of the pandemic, including when the omicron variant became dominant @CCPUKstudy @ISARIC1
19 Sep 2023
Researchers from @livuni have contributed to a paediatric study that provides valuable insights into the impact of Covid-19 on hospitalised children during the pandemic.
Read more here news.liverpool.ac.uk/2023/09…
@ProfCalumSemple
ALT An illustration of a doctor using a stethoscope on a child sitting on a mother's knee. Text overlaid reads: "These findings highlight the importance of considering different paediatric age groups when assessing disease severity in Covid-19 and can help play a role in public health policies." Professor Calum Semple, Professor of Outbreak Medicine and Child Health
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ISARIC4C retweeted
25 Aug 2023
Yes, along with loss of biodiversity, changing habitats of animals, illegal wild life trade, urbanisation, trade and travel. All key drivers more frequent & complex epidemics & pandemics. The epidemic events are symptoms of our changing world & need to address the key drivers
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ISARIC4C retweeted
30 Mar 2023
TL;DR:
Our preprint was 1ST to report association btwn #AAV2 & hepatitis cases, found on metagenomic sequencing in 9/9 early 🏴cases vs 0/58 controls. #adenovirus found in 6/9 cases.
Cases also >likely to carry HLA DRB1*04:01 allele (8/9; 89%) vs 🏴blood donors (16%) 2/
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30 Mar 2023
Doctors, scientists, & public health teams are working together, learning lessons from their responses to past outbreaks pandemics. This new way of working has led to the rapid discovery of the cause of this mystery disease @ISARIC1 @kennethbaillie @ProfCalumSemple
30 Mar 2023
🌟Proud to share our paper 'Adeno-associated virus 2 infection in children with non-A-E hepatitis', out in @Nature today!🌟
nature.com/articles/s41586-0…
@CVRinfo @UofGlasgow @P_H_S_Official @RHCGlasgow @CCPUKstudy
A🧵highlighting key updates from preprint released in July 2022 1/
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ISARIC4C retweeted
2 Mar 2023
U.S. FDA Advisory Committee (VRBPAC) voted support the safety and effectiveness of GSK AREXVY™ (RSVPreF3 OA), 12-0 on effectiveness and 10-2 on safety.
precisionvaccinations.com/rs…
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ISARIC4C retweeted
25 Jul 2022
Cases (n=9):
- admitted 14 March-4 April 22
- recruited to @CCPUKstudy
- 4 male; median age 3.9 (IQR 3.4-5.1)
- most had GI symptoms 1-11 wks b4 hepatitis
- no immunocompromise
- none had covid 💉
- Hep A-E, EBV/CMV, HHV6/7, HSV, autoantibodies neg
- no transplants/ deaths
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ISARIC4C retweeted
3 Aug 2022
@ISARIC1 @CCPUKstudy publication on our data platform. Thank you all partners & members for your contributions.
rdcu.be/cSWBU
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ISARIC4C retweeted
3 Aug 2022
Comment piece from David Ulaeto, Miles Carroll & me: Evolutionary implications of human transmission of monkeypox: the importance of sequencing multiple lesions thelancet.com/journals/lanmi…
We need multiple lesion samples & sequencing now to prove this @ISARIC1 @CCPUKstudy
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ISARIC4C retweeted
12 Aug 2022
Timely release of our latest @CCPUKstudy study, led by @LanceTurtle, evaluating impact of #immunocompromise (IC) on outcome in hospitalised #COVID19.
TL;DR: Despite effective 💉& Rx, IC individuals remain at ⬆️ risk of death from COVID19 compared to immunoconpetent persons.
12 Aug 2022
Today there is a lot of coverage of immune compromised people and whether the antibody treatment #Evusheld would benefit this population. Of relevance to this, is our latest pre-print on COVID-19 in hospitalised immune compromised people.
@evusheld4theuk
medrxiv.org/cgi/content/shor…
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ISARIC4C retweeted
25 Jul 2022
🚨New preprint🚨
Adeno-associated virus 2 infection in children with non A-E #Hepatitis
A case-control investigation of 9 early cases in #Scotland & 58 controls.
@CVRinfo @P_H_S_Official @RHCGlasgow @CCPUKstudy @ucl @UKHSA @emcat1
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medrxiv.org/content/10.1101/…
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25 Jul 2022
Great result and further evidence of the value of preparedness studies set up in readiness for future outbreaks of novel disease @gail_carson (the original CI), @ProfCalumSemple (CI & coLead) @kennethbaillie (coLead), @p_openshaw (coLead), @OutbreakJake & many more
25 Jul 2022
🆕 Recent acute #hepatitis cases of unknown origin in children have now been linked to the virus AAV2, with no evidence of a direct link to #SARSCoV2 infection, in two new studies led by @UofGMVLS @GreatOrmondSt and @UCLchildhealth.
Find out more ➡️ bit.ly/3vcAzRc
ALT Centre For Virus Research
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ISARIC4C retweeted
6 Jul 2022
Brilliant News Jo and Team. Thank you so much for your help with @CCPUKstudy @ISARIC1
6 Jul 2022
We won!!! So happy and so nice for all of us to be recognised for what we do during such a stressful time. Now let’s party!!! @LivuniILCaMS @livuniHLS @drchrisfrench
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ISARIC4C retweeted
6 Jul 2022
Many many congratulations to @ShonaCMoore, winning the Outstanding Contribution During The Covid-19 Pandemic, Shona and the team in our outbreak laboratories delivered the @CCPUKstudy which saved lives and enabled discovery on #COVID19
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1 Jun 2022
For UK hospitals that are ISARIC4C sites or are treating monkeypox patients and want to offer participation in the UK version of the CCP, see the updated UK CRF at isaric4c.net/protocols/
@CCPUKstudy
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ISARIC4C retweeted
1 Jun 2022
For UK hospitals that are ISARIC4C sites or are treating monkeypox patients and want to offer participation in the UK version of the CCP, see the updated UK CRF at isaric4c.net/protocols/ @CCPUKstudy
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