Impact of SARS-CoV-2 infection on subclinical myocardial injury in the general population: the Trรธndelag Health Study
๐จNORWEGIAN CONFIRMATION BOMBSHELL:
COVID infection leaves lasting, hidden scars on the heart muscle, even years later.
"An elevated cardiac troponin I (cTnI) level indicates the presence of heart damage!"
โก๏ธStudy:
- This was a prospective longitudinal cohort study within the Trรธndelag Health Study (HUNT), a large population-based survey in Norway,
- Researchers measured high-sensitivity cardiac troponin I (hs-cTnI), a sensitive blood marker of subclinical myocardial (heart muscle) injury, at baseline before the COVID-19 pandemic (2017โ2019) in 37,823 general-population adults,
- The same marker was then re-measured after the pandemic wave (2021โ2023) in the 19,550 participants who returned for follow-up,
- SARSCoV2 infection status was rigorously determined at follow-up via spike and nucleocapsid IgG antibody tests in blood, combined with self-reported infection history and any available laboratory confirmation of prior infection,
- Infection was defined using nucleocapsid IgG (specific to natural infection, not vaccination) plus spike IgG, self-report, and lab confirmation, precisely to capture true infections regardless of vaccination,
โก๏ธPre-infection result:
- Higher baseline hs-cTnI was associated with a lower risk of subsequent SARSCoV2 infection,
โก๏ธPost-infection result:
- Confirmed SARSCoV2 infection (any definition) was independently linked to higher post-pandemic hs-cTnI concentrations and a significantly greater probability of an increase in hs-cTnI from pre- to post-pandemic levels, after full adjustment for confounders and baseline troponin,
โก๏ธVaccination:
- Study reports that 98.9% of participants were vaccinated and explain(in Methods) why they used nucleocapsid IgG (not spike) to avoid vaccine confounding,
โก๏ธLimitations:
- Correctly sited and commented,
- No data on symptoms, asymptomatic/mild/severe cases, or hospitalization, but one may rightfully assume that the majority were mild SarsCoV2 cases,
โก๏ธConclusion:
โSARSCoV2 infection is associated with increased risk of developing chronic subclinical myocardial injury in the general population, but pre-existing chronic subclinical myocardial injury is not associated with increased risk of contracting SARS-CoV-2.โ
โผ๏ธTo all minimiser still shrugging off SARS-CoV-2 as โjust a coldโ or โoverโ: this Norwegian study proves every infection silently scars hearts across the general public with lasting subclinical damage, and with the now-established cumulative cardiac injury from reinfections, your denial is quietly killing many! WAKE-UP!
#AvoidSars2 #AvoidReinfections
academic.oup.com/eurjpc/advaโฆ