Caitlyn Holmes. Incoming Assistant Professor at the U of Minnesota studying Klebsiella-host interactions. Postdoc: Bachman Lab. Alum: UW-Madison, UCF. #KlebClub
An Update! π I am so happy to announce that in May 2025, I will be joining the University of Minnesota as an Assistant Professor in the Department of Microbiology & Immunology. My lab will study host-pathogen interactions during Klebsiella systemic infection.
I'm excited to announce our latest publication! We teamed up with @KHullahalli to barcode Klebsiella and ask basic questions about bacteremia pathogenesis: 1) how are bacteria shared between sites and 2) which host and bacterial factors influence dynamics?
nature.com/articles/s41467-0β¦
Klebsiella leaves the lung in two distinct patterns, termed "metastatic" and "direct", which are defined by the extent of clonal replication in primary tissues and predict bacterial burden across sites. Oxidative stress from the host and bacterial LPS influences these patterns.
Thank you to all collaborators for helping to sort through this huge set of data and to the barcoding community for your help in comparing our trends to other systems! This is truly a study were I made friends and collaborators along the way. β
It's that time of year! Registration and abstract submission for the 6th Klebsiella Seminar Series is now open. Participation is free and abstracts are due by February 16th. See the link below for details:
forms.gle/gxbvaC6FjzuSPtjD9#KlebClub
I'm so happy that this paper is finally published! This one was a long time coming: 9 years, 3 pairs of hands, 270 strains, 93 plasmids, and a lot of hard work. It started as a side project that eventually led to my entire dissertation, and I'm glad it did.
Superb @mSystemsJ study by @RuthlessRuth15 et al from @markjmandel
Functional analysis of cyclic diguanylate-modulating proteins in Vibrio fischeri
"protein OE to systematically characterize the functional potential of all 50 V. fischeri proteins"βοΈ
journals.asm.org/doi/10.1128β¦
New article!β¨In this review, we present a broad overview of bloodstream infections, consider microbial pathogenesis mechanisms, and discuss how these strategies could be used in future therapies. #KlebClub
Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention
Holmes, Bachman & co. explore major pathogens causing bloodstream infections, their pathogenesis, opportunities for prevention, diagnosis & treatment options.
An Update! π I am so happy to announce that in May 2025, I will be joining the University of Minnesota as an Assistant Professor in the Department of Microbiology & Immunology. My lab will study host-pathogen interactions during Klebsiella systemic infection.
This has truly been an exciting process, and I have been supported (from the very beginning) by an all-star team of mentors, collaborators, and coworkers. A big thank you to everyone who has helped make this a reality!
Hey #KlebClub! Are you going to #Microbe2024? Join us for our #KlebClub get-together π on Friday from 5-6 PM! If you plan on attending, please reply with the number of folks there so we can plan accordingly!
Come join us on the @KlebClub Organizing Committee! This community is a great way to engage with others in the field, and the committee is very flexible and supportive. Feel free to contact us if you have any questions.
KlebClub is looking for additional members to join our organizing committee!π§ͺ
Specifically, we are seeking 1-3 graduate and postdoc trainees to assist with new a community engagement initiative. If you are interested in joining, see the link below! π
forms.gle/JtYamucXrb9Wsqs57
So excited to share news of my K99 NOA from @NIAIDFunding! This award will allow me to expand my interests in Klebsiella pathogenesis and host-pathogen interactions during bacteremia, and I am thankful to continue this work into future projects.π¦
There are many people to thank for their support - I am fortunate to work with mentors who are dedicated to trainee success. Particularly, I want to highlight @Bachman_Lab, @andolive85, and @bmoore_beth for their encouragement starting all the way back at the first draft. π
New pre-print up today! We used bacterial barcoding to measure infection kinetics during bacteremia initiation from the lung. This collaboration was so fun (@KHullahalli and @kg_dailey) and the results were unexpected!
The fifth Klebsiella Seminar Series starts on Thursday! Join us to learn from our community about the latest Klebsiella research. Registration is still open!
It's time! Klebsiella Seminar Series starts this week!πWe are thrilled to announce the 2024 program and are excited to hear the latest Klebsiella research. #KlebClubπ¦ See you on Thursday!
Registration is free and still live at: sites.google.com/view/klebclβ¦