Heading to the @ISCTglobal Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts. We’ve built an integrated platform designed to move programs from discovery into first-in-human studies with rigor, speed, and quality. What differentiates this model is not a single capability, but the integration: • cGMP Phase I manufacturing in 15 ISO 7 suites • Process development and scale-up for complex cell therapies • End-to-end QC analytics and FACT-aligned quality systems • Advanced correlative science, including multiparameter flow, molecular assays, and spatial biology • Deep experience translating across oncology and immune diseases We are actively looking to partner with biotech, pharma, and academic groups in three areas: • Manufacturing: early-phase and first-in-human CGT production • Process development: improving robustness, scalability, and comparability • Analytics and correlative studies: biomarker strategies that inform mechanism, response, and durability If you are advancing a program and need a partner who understands both the science and the realities of clinical translation, we should connect to build the next generation of cell and gene therapy together. #celltherapy #genetherapy #innovation #immunotherapy

Check out our latest paper, published @NatureComms. We show that STING activation induces IL18 secretion and thereby enhances CAR T function. Great collaboration between @CarlHJune lab and James Chen @UTSWMedCenter. @PennMedicine @PennMDForum @PennPPA nature.com/articles/s41467-0…

wonderful work from @sonia guedan, former post doc. From her lab in Barcelona,j ust published in Nature Communications doi.org/10.1038/s41467-024-4…

Anti-competitive practices of 10X genomics have forced Nanostring into chapter 11 restructuring. 10x has initiated litigation against not only Nanostring but also Vizgen, Curio Biosciences and Parse Biosciences. See below for more information: (genengnews.com/topics/bioper…) (genengnews.com/topics/omics/…)

x.com/sixers/status/17499155… My lab in Spotlight at 76ers historic game when Embiid scored 70 points and set a franchise record for the 76ers. @PennMedicine

Tons of promising work using CAR T cells beyond cancer. Already showing signs of efficacy in early clinical reports. Check out our review in @Nature of this rapidly evolving field! W/ @AranyLab @BaurLab @jonepstein1 @carlhjune nature.com/articles/s41586-0…

thrilled that Bruce Levine to receive PMWC 2023 Pioneer Award. linkedin.com/posts/pmwcintl_…

What can happen when #CARTcell Therapy Meets #ClonalHematopoiesis? @CarlHJune puts multiple scenarios InFocus @BCD_AACR aacrjournals.org/bloodcancer…

CAR T in Costa Rica

10 years ago Emily Whitehead’s family got the news that she was cancer free. We wondered whether these #carTcells could keep her in remission and cure her disease without BMT. Now we know. 10 years from this transformative clinical experience, 5 years from @FDA approval.

The June lab is excited to offer a postdoctoral position with a focus on T cell engineering and synthetic biology in the Center for Cellular Immunotherapies at the Perelman School of Medicine at the University of Pennsylvania.

Penn Patients with Decade-Long Leukemia Remissions after CAR T Cell Therapy Reveals New Details About Persistence of Personalized “Living Drug” Cells. Delighted to announce our study in Nature today

Was $NVS BELINDA #CARTCell #tcellrx vs SOC Phase III failure in #lymphoma due to manufacturing?? If 2% serum used in ex vivo media, acknowledged 2B inferior to 5% in #ASH21 poster 1768. 5% only used from end 2020 onwards. #lymsm #immunotherapy ash.confex.com/ash/2021/webp…

brave scientists against Texas Bravo Tom Curran and Myles Brown: Two members of the highest-level review board of the Cancer Prevention and Research Institute of Texas have submitted their resignations from the board of the state-funded institute.

I've had it with gun violence. The husband of my 3rd cousin was shot and is now hemiplegic in a senseless drive by shooting. Yakima man hit in drive-by shooting while working in yard in Barge-Chestnut area | Crime And Courts | yakimaherald.com yakimaherald.com/news/crime_…

Visionary philanthropist Barbara Netter has made a profound impact on science & medicine. With late husband Edward, they founded @ACGTFoundation whose mission is to fund #celltherapy #genetherapy #research to empower pioneering and innovative scientists phillyfightscancer.org/2020/…

AT 10 years I think we can say our first CAR T patient is cured.

We are so lucky to have you at the helm! Thanks for the leadership, inspiration, vision and steady hand in these challenging times.

Great article in the NYT from Gina Kolata. Nice analysis of what we know about immune heterogeneity and how it might relate to treatments How the Coronavirus Short-Circuits the Immune System - The New York Times nytimes.com/2020/06/26/healt…