Scientist - Single Molecules, Biophysics, Droplets, Membranes, Microfluidics & SynBio - Cardiff University Research Fellow & Senior Lecturer

Joined April 2016
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Haven't been on here much, mainly due to recovering from longcovid and it being exhausting. Despite all that, v.pleased with our latest collaborative work (aptly) on rapid SARS-CoV-2 variant detection with ability to discriminate single nucleotide changes. medrxiv.org/content/10.1101/…
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Oliver Castell retweeted
3/ The cross-School @cardiffuni Screening Service based in @CUBiosciences , led by Dr Tomasz Jurkowski and Prof Pete Kille - winner of the “Exceptional Enhancement of Staff Wellbeing” award
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Congrats to Tomasz!! Well deserved.
Replying to @CUBiosciences
1/ Dr Tomasz Jurkowski - winner of the "Vice-Chancellor’s Award for Outstanding Contribution to the University" - for his "extraordinary action" in his central role establishing the university's #COVID19 testing service. This is the only award chosen by the Vice-C!
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Oliver Castell retweeted
7 Feb 2022
The first comprehensive assessment of the cardiovascular complications of #LongCovid at 1 year, just published @NatureMedicine nature.com/articles/s41591-0… by @zalaly and colleagues @WUSTLmed
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People seemed to quite like levitating droplets, so a couple more vids from @JinLi_AOR First, Jin shows you can spin and reshape droplets, using this to break/reform lipid bilayers (DIBs) between internal cores, and to reconfigure the droplet network. biorxiv.org/content/10.1101/…
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@JinLi_AOR did an great job driving this work. I’m sure he’d be keen to give a talk/seminar if anyone's keen to hear more. Give him a follow too!
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Excellent stuff from @WDJamieson on the protein assays and microscopy too!
Oliver Castell retweeted
Wordle 2022 5/5 (with apologies to outbreak.info)
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We've a new pre-print "Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation" up on @biorxivpreprint. Great effort by @JinLi_AOR on this work. biorxiv.org/content/10.1101/…
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As @DrMikeBooth's team point out in their recent review (frontiersin.org/articles/10.…) control of artificial cells is going to be vital for future applications. Here we address this by using ultrasonic & magnetic fields to selectively activate MscL channels in work with @phatmattbaker
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Levitating artificial cells is kinda fun in itself, but @JinLi_AOR also shows how this can be used with microfluidics to reorganise, pattern and manipulate the internal structure and connectivity of artificial cells & also control function with selective activation/deactivation.
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Think I found myself in a rarely occupied room today. "if you have returned from certain towns in regions of northern Italy...."
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Oliver Castell retweeted
Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation biorxiv.org/cgi/content/shor… #bioRxiv

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This is a great move...
Oliver Castell retweeted
VarLOCK approach for rapid detection of SARS-CoV-2 variants of concern and wastewater monitoring news-medical.net/news/202201… @medrxivpreprint @cardiffuni @BangorUni #SARSCoV2 #COVID19 #coronavirus #covid #virus #variantofconcern #wastewatermonitoring
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Haven't been on here much, mainly due to recovering from longcovid and it being exhausting. Despite all that, v.pleased with our latest collaborative work (aptly) on rapid SARS-CoV-2 variant detection with ability to discriminate single nucleotide changes. medrxiv.org/content/10.1101/…
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We applied to wastewater samples as well. In Cardiff, Swansea & Newport. We see the change in dominance from wildtype to Alpha to Delta - perhaps not surprising - but we also pick up the presence of Beta VoC in the community in a high background of Alpha. Useful for surveillance?
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Can be readily adapted to any newly identified VOCs or other pathogens. Lots of hard work from Xinsheng and @tomek_criters and everyone really, but especially these two. Great project to be involved in. Have a read here (pre-print, not yet peer-reviewed) medrxiv.org/content/10.1101/…