PhD in Neurosciences, University of Ottawa. Synaptic electrophysiology & cortical plasticity.
Joined July 2011
- Tweets 111
- Following 296
- Followers 233
- Likes 280
18 Photos and videos
Pinned Tweet
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
14 Jul 2024
Wow, this is great!! Fantastic teaching resource to boot.
12 Jul 2024
For a refresher on the great classics, or a glimpse into the future, check out this review by @JCBeique & I on 50 years of Long-term Potentiation, and what the next 50 years might hold!
cell.com/current-biology/ful…
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12 Jul 2024
For a refresher on the great classics, or a glimpse into the future, check out this review by @JCBeique & I on 50 years of Long-term Potentiation, and what the next 50 years might hold!
cell.com/current-biology/ful…
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Léa Caya-Bissonnette, PhD retweeted
19 Feb 2024
Clustering model parameters across hundreds of synapses, we found five functional subtypes of synaptic dynamics in rodents and six functional subtypes in humans which show qualitative overlap (though based on existing data we don’t expect a perfect overlap).
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20 Feb 2024
MUST read - Amazing work showing functional clusters of short term plasticity! Congrats @jgbeninger 🎉👏
19 Feb 2024
Interested in short-term plasticity? Our recent findings have just been published! With @Neuronaud @mossy_fibers @j_rossbroich
Online: cell.com/cell-reports/fullte…
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Léa Caya-Bissonnette, PhD retweeted
11 Jan 2024
If you're interested in dendritic computation, our most recent findings are just published! With @Z_Friedenberger and at @NatComputSci
Direct access: rdcu.be/duzz9
Online: nature.com/articles/s43588-0…
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Léa Caya-Bissonnette, PhD retweeted
13 Dec 2023
I’m pretty overdue but this photo reminds me of this exciting day when I had a chance to moderate the trainee talks along with @CayaBissonnette at Centre for Neural Dynamics Research Spotlight organized by @uOttawaBMRI, & enjoy a beautiful talk by @nspruston back in September!
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Léa Caya-Bissonnette, PhD retweeted
23 Sep 2023
A new theory of serotonin function: it encodes "cumulative future reward" aka state value biorxiv.org/content/10.1101/… Compared to dopamine, serotonin is a lot more mysterious
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22 Sep 2023
Great piece of work by @efharkin_ on serotonin and value encoding 👏
21 Sep 2023
What do you get when you combine RL and predictive coding? The in vivo activity patterns of serotonin neurons.
Excited to share a new theory and analysis to back it up! doi.org/10.1101/2023.09.19.5…
With @NeuroNaud and @JCBeique in collab with @grossmancooper & @JeremiahYCohen.
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Léa Caya-Bissonnette, PhD retweeted
10 Aug 2023
Great work! We also have a calcium-dependent model of a different aspect of BTSP here: biorxiv.org/content/10.1101/…, I'd be interested in hearing your thoughts - maybe you can DM me and we can talk over Zoom some time?
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Léa Caya-Bissonnette, PhD retweeted
6 Jul 2023
Very interesting paper, thanks for sharing! So cool that you are also venturing into the molecular world and building a bridge to the circuit level.
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Léa Caya-Bissonnette, PhD retweeted
10 Jul 2023
Beautiful work by @CayaBissonnette @NeuroNaud @JCBeique
Cellular Substrate of Eligibility Traces biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
6 Jul 2023
Intracellular calcium steadily making its overdue comeback to the big stage 🫡🍿
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
5 Jul 2023
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
5 Jul 2023
Outstanding work by great people - a cellular model of eligibility traces! Check it out 🎉
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
22 Apr 2022
Part 2 of my PhD finally published! w/@ranczlab & @ZhiwenNeuron
How do feedforward and feedback connections target L5 neurons? 🧵
TLDR; Dendritic targets are tightly specified, but may surprise you. “FF = basal, FB = apical tuft” is not a universal rule!
bit.ly/tL5b
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Léa Caya-Bissonnette, PhD retweeted
1 Mar 2023
What does the serotonin system compute? 🤔
🎉 I'm excited to finally be able to share a long-term project with @JCBeique and @NeuroNaud to create an experimentally-constrained bottom-up model of the dorsal raphe nucleus, just published in @eLife!🎊
doi.org/10.7554/eLife.72951
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Léa Caya-Bissonnette, PhD retweeted
5 Jul 2023
Super cool results! Glad to see the full paper out after the preview we got at Cosyne
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
6 Jul 2023
How can individual neurons learn to associate events that don't happen at exactly the same time? 🤔 Léa provides a mechanistic answer: synaptic loading and unloading of ER calcium stores. 😲
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
6 Jul 2023
Few-shot plasticity in the cortex unfolds with big calcium events. With these rare events, calcium stores act as temporal buffers, extending the timescale for associating pre&post activity to seconds. But there is much more in Léa's work. Check it out!
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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Léa Caya-Bissonnette, PhD retweeted
6 Jul 2023
Possible mechanism of behavioral timescale plasticity!
5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique
biorxiv.org/content/10.1101/…
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