Cell Discovery, published by Springer Nature & CEMCS, CAS, presents research of high significance and broad interest in all areas of molecular and cell biology
#TMEM41B is an endoplasmic reticulum Ca2 release channel maintaining naive T cell quiescence and responsiveness by Min Peng, Bingqing Xia, Zhaobing Gao & co nature.com/articles/s41421-0…
RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease by Hua-Bing Li, Jing Zhou, Ping Wang & co @sjtu1896nature.com/articles/s41421-0…
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics by Ling-Qiang Zhu, Dan Liu, Kai Shu & co @2024_HUSTnature.com/articles/s41421-0…
MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury by Weiwei Yang & co @ CEMCS, CAS nature.com/articles/s41421-0…
Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure by Han Zhao, Zi-Jiang Chen, Yuqing Zhang @ShandongU & co nature.com/articles/s41421-0…
Human DDIT4L intron retention contributes to cognitive impairment and amyloid plaque formation by Xu Zhang, Ying Mao & co nature.com/articles/s41421-0…
NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters by @ahoffmann2716, Jennifer J. Chia & co @UCLAnature.com/articles/s41421-0…
A tumor-secreted protein utilizes glucagon release to cause host wasting by Wei Song, Zhiyong Yang, Yufeng Yuan & co @WHU_1893nature.com/articles/s41421-0…
Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in #hepatocellular carcinoma by Jia Fan, Kui Wu, Yidi Sun, Hu Zhou, Qiang Gao & co nature.com/articles/s41421-0…
Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells by Feng Liu @ IOZ, CAS, Jing-Dong Jackie Han @PKU1898 & co #HSPCnature.com/articles/s41421-0…
Don't miss this new @CellDiscovery release! 📣
Findings suggested that placental hemogenic endothelial cells possess the potential to transform into self-renewing induced #HSPCs through retinoic acid treatment.
🔎 Discover more: go.nature.com/3WEEGTI
Scientists from @CAS__Science generated functional HSPCs in vitro from #endothelial cells (ECs) at various sites, including the aorta-gonad-mesonephros region and the placenta, by engineering vascular niche ECs.
🖨️ @CellDiscoverygo.nature.com/3WEEGTI
By combining pathological image analysis with spatial proteomics, scientists with Dr. Jia Fan revealed two stromal archetypes in #HCC with different biological functions and #ECM compositions.
👉 Read their @CellDiscovery study: go.nature.com/3Cv2pz4
In this new @CellDiscovery study, researchers established a fusion system between androgenetic-haploid ESCs (haESCs) and parthenogenetic-haESC lines with parent-of-origin-specific-DMR edits to produce diploid #ESCs carrying DMR-deletion combinations.
🔗 go.nature.com/3CkOr2I
Thrilled to introduce a new single-cell 3D genome analysis tool to our toolkit! Our high-throughput droplet Hi-C (dscHi-C) and dscHi-C-multiome methods use droplet microfluidics to generate tens of thousands of single-cell Hi-C profiles with high sensitivity in a single batch.