🎉 Happy to share this review on such a relevant topic. 🤗Thanks to @JHmeljak for being a great and very helpful editor and @dmm_journal @Co_Biologists for their fantastic editorial process. 🧵👇🏼 Caenorhabditis elegans for research on cancer hallmarks journals.biologists.com/dmm/…

Nice overview of one of the most amazing animals on Earth! @gusaneros1 @annajuanroch @AMV_REDOX @raticosde100cia @IISLaFe From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism | PNAS pnas.org/doi/10.1073/pnas.25…

Time to get ready for the Spanish Worm Meeting!! swm2026.com/

El pasado lunes recibimos a Gary Ruvkun, Premio Nobel de Medicina 2024, invitado por @PremiosReiJaume en el @IBV_CSIC Conoció a personal, IPs y estudiantes, compartiendo experiencias y consejos científicos. ¡Gracias a todos los participantes! 💙 #IBVCSIC #Ciencia #Nobel

We are geting closer to the deadline!! swm2026.com/ Register yourself, guys! Worms are one of the coolest creatures on Earth @ehuntingtones @AsociacionAVAEH @FEDER_ONG @LluisMontoliu

Come on guys and girls! We're getting closer to the deadline for the one and only, awesome, incredible, and amazing X Spanish Worm Meeting in the lovely city of Valencia! swm2026.com/

🧬 Compact CRISPR nucleases are small — but often slow to activate. A new strategy just fixed that. New preprint from Liu Junjie lab (Tsinghua): fusing ATPase DnaA to PlmCas12e (CasX) via a rigid N-terminal linker overcomes the conformational activation barrier. ⚡ 1.34× average editing boost across 7 endogenous loci in HEK293T 📈 More effective genome targets detected by GenomePAM/GUIDE-seq 🔬 MD simulation: single free-energy basin vs. rugged landscape in WT ❌ ATP hydrolysis mutant: activity drops below wild-type — mechanism confirmed Liu lab, Tsinghua | Preprint doi.org/10.65215/LTSpreprint… #CRISPR #Cas12e #CasX #ProteinEngineering #GeneEditing

📢 ¡𝗢𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝗱𝗮𝗱 𝗽𝗿𝗼𝗳𝗲𝘀𝗶𝗼𝗻𝗮𝗹 𝗲𝗻 𝗜𝗕𝗩-𝗖𝗦𝗜𝗖! Vacante para Investigador Distinguido en inmunología, identidad celular y biología computacional con IA. 🔒Posición permanente y start-up package. 👉Más Info en: call.valer-f.es #ibvcsic

🧬 CRISPR evolution — directly inside human cells — for the first time. PNAS: CRISPR-MACE uses adenovirus replication to continuously mutate, select, and amplify Cas9 variants in human cells, bypassing bacterial evolution limitations. Key results: 🔑 "Gatekeeper" G12D mutation: 3× higher DNA affinity 💪 DVKIH 5-mutant variant: ~1000× anti-CRISPR resistance ✅ Validated in CASFISH imaging — brighter, stronger signal Shoulders & Choudhary labs, Broad Institute | PNAS doi.org/10.1073/pnas.2536003… #CRISPR #DirectedEvolution #Cas9 #GeneTherapy #Broadinstitute

La burocracia es una lacra en todos los aspectos. Pero en el campo de la ciencia, va a acabar con ella...

The round table featuring all speakers and moderated by Francisco Martin and Marcello Maresca was a great brochure for the session on the novel Gene Editing Tools. @GeneHumdi #Granada2026 #AnnualMeeting @genyo_pts

We are back at @GeneHumdi #Granada2026 #AnnualMeeting with a session focussed on new tools for the advancement of #GenomeEditing at @genyo_pts with support of @FProgresoysalud

Closing the session, two short talks: First Araceli Aguilar @genyo_pts presents "A novel dual-guide CRISPR–Cas13 strategy for enhanced SNV detection" with clear implications to improve diagnostic use of CRISPR tools.

We are opening with Julian Cerón @CeronLab presenting how old Deep Ocean organisms can surface novel discories to help #GenomeEditing

Everything Ready for the 2026 @GeneHumdi #AnnualMeeting at @genyo_pts . Looking forward to the discussions and expositions paving the way for clinical gene editing