"Bioinformaticien, je développe des outils pour retrouver les chemins que tu empruntis... en te spécialisant" Quelle joie d'expliquer son métier avec humour ! InVivo, merci @FondationARC et @KarimDuvalShow. @Univ_CotedAzur @discovAIR_HCA tinyurl.com/dtndkjj4

(1/n) The first preprint from our lab is now out in @NatureGenet! We tried to tackle a key challenge in spatial biology to quantitatively characterizing cellular niches by learning spatial gene programs using NicheCompas led by @SebastianBirk_. Paper: shorturl.at/b4Hjk

Excited to share Nicheformer! Led by @Alejandro__TL & @AnnaCSchaar, Nicheformer is a foundation model for single-cell & spatial omics. Its innovation is going beyond disassociated analysis to capture & predict local tissue context at single-cell level. biorxiv.org/content/10.1101/…

L'article "IA et bioinformatique : exploitons les réseaux convolutionnels (CNN)" bioinfo-fr.net/ia-et-bioinfo… est maintenant disponible ! Suite de "Bioinformatique et IA : un premier pas", nous explorons ici les classifications à classes multiples.

L'aventure commence ! 💪😁🤩 J'entame la rédaction de mon HDR. (Titre provisoire)

Thank you to all the volunteers who manned the #sfbi stand throughout the #ISMBECCB2023 conference. Thank you to the "Bioinformatics in France" session organizers and especially to our president @afiston for her commitment. @EG_bioinfo @CorentinMarco34 @Seajulll Jérémy Riwan

Full auditorium for @LauCan88 keynote @ISCB_RegSys on "Multi-modal learning for single-cell multi-omics data integration" #RegSys #ISMBECCB2023

A wonderful evening in your company! Thanks to all! #ISMBECCB2023

Come and see us at the SFBI stand at the ISMB/ECCB 2023 conference in @villedelyon. #ISMBECCB2023

This morning at #ISMBECCB2023 kicked off by a Dana Pe’er keynote on ML meeting single-cell biology. Started with a disclaimer that she went to Paul Bocuse last night and it was a late one

Ever analyze a scRNAseq dataset and wonder if a specific cell state has been seen before? And if so, where in the human body? Under what conditions? Well, now you can use our lightning fast SCimilarity search and foundational model for that! ⚡️🔎🧬 biorxiv.org/content/10.1101/… (1/11)

A mind-blowing paper has come out today in @Nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/scie…). Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome. The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution. Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell. When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part. The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival. The conclusion of the paper is metaphorically a quote from the Jurassic Park movie: “Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (scienmag.com/artificial-cell…) nature.com/articles/s41586-0…

JOBIM2023 @VilledeNice .....ils savent recevoir ! On le note pour les prochaines éditions ;) @jobim2023 #bioinformatics

Fin de 3eme journée, journée très dense, qui va se finir... Ici ! Début du gala @jobim2023 @nice

3eme jour de @jobim2023 visite du musée d'archéologie de Nice et des thermes romains

On clos ici les conférences pour aujourd'hui ! Merci pour votre participation et pour vos questions pertinentes 💡 ! 📸 Vous nous tweeter des photos de vos activités sur site ? #JOBIM2023

Bilan de la 2eme journée de @jobim2023 Amphithéâtre de l'INSPE plein toute la journée !!! @Univ_CotedAzur A demain 😉