MB-PhD candidate • Bioinformatics and immunology • @Cambridge_Uni • @Kings_college • @Gates_Cambridge alumnus 🇸🇬🏃🏻⚽️
Joined November 2020
- Tweets 611
- Following 516
- Followers 493
- Likes 1,544
34 Photos and videos
Pinned Tweet
24 Jan 2024
Interested in tumour immunity, dendritic cells and immunotherapy? Excited to share our study on CCR7 dendritic cells (DCs) in cancer out today, a joint effort between @LabWithers and @ClatworthyLab. (🧵 1/8)
nature.com/articles/s41467-0…
7
37
164
23,742
Colin Lee retweeted
Jun 11
THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS:
Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/10.1056/NEJMoa2…
12
103
435
46,775
Colin Lee retweeted
Feb 9
Sneak peak of upcoming sc-dandelion 1.0.0 release!
Read, process and plot 1M single-cell AIRR data e.g. @ParseBio's data in <15min without GPU! #singlecell #bcr #tcr
2
3
401
Feb 4
Great to see this really cool piece of work now out in @NatureGenet led by superstar @elizabetha_coop. Check it out!!
I am excited to share our latest research out today
@NatureGenet; here we discovered childhood brain tumours instruct cranial hematopoiesis and identify a clinically relevant mechanism to re-educate the skull bone marrow.
nature.com/articles/s41588-0…
1
254
Colin Lee retweeted
28 Sep 2025
Very excited to share our latest preprint – We find that childhood brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. A thread 1/11
biorxiv.org/content/10.1101/…
@Gilbertson_Lab @CRUK_CI @LPTrustUK @BrainTumourOrg
3
17
52
5,470
Colin Lee retweeted
20 Sep 2025
PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.
32
175
937
73,602
Colin Lee retweeted
23 Sep 2025
In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
doi.org/10.1158/2326-6066.CI… @ColinYCLee @ClatworthyLab and @LabWithers
1
3
426
21 Aug 2025
Our latest study using the photo-convertible Kaede model to track tumour-infiltrating leukocytes and their changes over time is now out in @CIR_AACR! doi.org/10.1158/2326-6066.CI… @ClatworthyLab @LabWithers
1
3
11
680
21 Aug 2025
We identify spatially, temporally and functionally distinct tumour-associated macrophage (TAM) populations that undergo rapid changes following tumour infiltration. Immune checkpoint therapy promotes pro-inflammatory IFNγ-driven responses in newly-entered monocyte-derived TAMs.
1
1
207
21 Aug 2025
If interested, do also check out our previous related work using the Kaede model to study the temporal dynamics of *DCs* (doi.org/10.1038/s41467-024-4…), *NK cells* (doi.org/10.1038/s41467-024-4…) and *T cells* (doi.org/10.1084/jem.20210749); review article (doi.org/10.1111/imcb.12787).
109
Colin Lee retweeted
6 Jun 2025
We have a PhD position opening for Australian domestic students interested to work at the intersection of immunology, data science, and paediatrics! Check out the full description here!
linkedin.com/posts/ian-fraze… @YUmmunology
1
5
4
838
Colin Lee retweeted
7 Apr 2025
CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type!
nature.com/articles/s41588-0…
2
151
542
54,945
Colin Lee retweeted
29 Mar 2025
Thank goodness people are waking up to the fact that there is a crisis for clinical research in the UK @FT
High on the list are the bureaucratic processes that have become such an obstacle to getting things done
5
32
86
10,834
Colin Lee retweeted
27 Mar 2025
Review @jacionline @ClatworthyLab @ColinYCLee
Profiling immune cell tissue niches in the spatial -omics era
jacionline.org/article/S0091…
7
58
3,556
7 Mar 2025
Check out our discussion (@ClatworthyLab) on the use of Spatial Transcriptomics for investigating immune niches in this month's issue of @jacionline
The March issue of JACI is now online! Check it out here: jacionline.org/current
This month's theme focuses on Spatial Transcriptomics.
Read the Editors' Choice summaries from the March issue here (free to read/download): authors.elsevier.com/a/1khQa…
2
12
874
Colin Lee retweeted
Recent developments in high-throughput spatial -omics technologies have facilitated a more comprehensive understanding of tissue immunity. Learn how they have generated new insights in translational immunology and what the future might hold. bit.ly/41tH15E
1
2
457
25 Feb 2025
Huge! 🎉🎉
24 Feb 2025
Veryy happy to share that I got lucky this round and was successful in my #NHMRC Investigator Grant! Thanks to my past and present mentors @YUmmunology @ClatworthyLab @teichlab who helped shaped my career thus far!
3
243
Colin Lee retweeted
24 Feb 2025
Veryy happy to share that I got lucky this round and was successful in my #NHMRC Investigator Grant! Thanks to my past and present mentors @YUmmunology @ClatworthyLab @teichlab who helped shaped my career thus far!
Congratulations to TRI-based researchers/clinicians sharing in @nhmrc support to advance work in kidney disease, blood cancer and gut health (pictured from right): @DWJohnsonNeph, @KelvinTuong and @AyeshaShah717. @UQ_News, #FrazerInstUQ, @qldhealth
5
1
23
1,391
Colin Lee retweeted
22 Feb 2025
Fancy a 4-year post-doc in Cambridge, working in both the biggest biomedical centre in Europe @psychiatry_ucam @CambridgeBRC and the genetic powerhouse of the @sangerinstitute?
1
13
22
3,353
Colin Lee retweeted
20 Feb 2025
Cancer neuroimmunology is real. Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis | Nature nature.com/articles/s41586-0…
2
44
177
21,201