Group of UK scientists and international advisors aiming to advance research in cryobiology and cryonics. Our goal is to use technology to defeat death.

Joined May 2015
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Cryonics and Cryopreservation Research Network retweeted
Another book on curing aging promised - in 2000 - that science was on the verge of providing physical immortality thanks to genetic engineering, neuroscience, and cloning. A quarter-century later, we're still waiting. Sadly, the author passed away last year.
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Cryonics and Cryopreservation Research Network retweeted
There is no future for anyone currently reading this if we don’t solve aging. Awesome Vision Weekend in London from @foresightinst discussing what the future may look like and the technologies shaping it.
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Cryonics and Cryopreservation Research Network retweeted
Gene expression can be used to predict age and mortality 🚨 Impressive study from @gladyshev_lab @harvardmed using RNA-seq data to develop accurate transcriptomic clocks across mammalian species (inc. humans) and tissues to predict age, lifespan and mortality. A great example of the power of big data in aging research. Major processes changing with age include inflammation, mitochondrial function, epigenetic regulation, cell cycle (inc. markers of cellular senescence) and extracellular matrix remodeling. These clocks will have applications in personalised medicine, drug discovery and clinical trials. They also suggest some degree of coordination of aging changes. However, many questions remains. Are age-related transcriptomic changes drivers of aging or merely passengers? In other words, if we normalized these aging changes back to youthful levels, would this be beneficial, detrimental, or have no effect? And with so many aging clocks now available, how will researchers determine which ones are most biologically meaningful and clinically useful? Link to original paper: nature.com/articles/s41586-0… My thoughts on the study: nature.com/articles/d41586-0…
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Electric fields for warming cryopreserved tissue sciencedirect.com/science/ar…
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Cryonics and Cryopreservation Research Network retweeted
This is all solid advice on sleep, diet, exercise and lifestyle. I encourage folks to follow it. But we're not going to sleep our way to 150 years. We need interventions that target the biology of aging to make real progress in longevity.
This is it. Everything learned spending millions on longevity. From: Your Immortal Unc and Auntie. To: Our Immortal nieces and nephews. 0. Sleep is the world's most powerful drug. 1. Be in your bed for 8 hours 2. Same bedtime every night, any time before midnight 3. Don’t eat right before bed 4. Calm foods for dinner 5. No screens 1 hour before bed 6. Avoid added sugar (be aware it’s in everything) 7. Avoid all things in an American convenience store 8. Avoid fried foods 9. Shoes off at the door 10. Eat whole foods, particularly veggies fruits nuts legumes berries 11. Walk a little after meals or air squats 12. Get your heart rate high routinely 13. Lift heavy things 14. Stretch daily 15. Water pik, floss, brush, tongue scrape, morning and night 16. Make an effort to drink water 17. Get sunlight when you wake up (UV is low) 18. Protect skin in midday sun 19. Stand up straight 20. See at least one friend once a week 21. Avoid plastic where you can (in all things) 22. Circulate air in rooms 23. When stressed, breathe, learn to calm your body 24. Go to the dentist 25. Avoid sitting for long times 26. Protect your hearing, the world is too loud 27. Alcohol is bad for you 28. Finish coffee before noon 29. Avoid bright lights after sunset 30. If obese, look into a GLP 31. Sleep in a cold room 32. Texting while driving is dangerous 33. Turn off all notifications 34. Limit social media use 35. Don’t smoke anything 36. If you struggle to sleep, read a physical book before bed 37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music 38. The body is a clock and loves routine. Have a daily morning and evening schedule. 39. Avoid long distance travel where you can 40. Baby steps first: incorporate new things slowly 41. Do less… most things don’t work. Bonus points if you get your blood checked. Start here, it will change your life.
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Cryonics and Cryopreservation Research Network retweeted
Biogerontology will not save most people alive today. Even in an optimistic scenario, it will likely deliver gradual therapies: less inflammation, better immunity, less frailty, some organ improvements, maybe 5–15 years for some people. But not mass rescue from death. There are around 8.2 billion people in the world today. Global life expectancy is around 73 years; as the population ages, the number of deaths will rise. WHO gives global life expectancy as 71.3 years in 2021; the UN gives 73.3 years in 2024. Replacement is hard to scale and will not rejuvenate everything — for example, the blood vessels of the brain. Without a radical change in strategy, several billion people alive today will die before true negligible-senescence medicine arrives. Five billion deaths is my lower estimate. Realistically, it will be more. This leads to an unpleasant conclusion: We need not only biogerontology, but a strategy for survival through death. Without cryonics, immortalism is effectively agreeing to write off almost everyone who will not live long enough to reach radical medicine. Do we want death for our parents and for 80% of everyone we know?
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Cryonics and Cryopreservation Research Network retweeted
Ageing isn't one disease, it's a network. Excited to share our latest study exploring the genetic links between ageing and age-related diseases 🧬 We show how shared pleiotropic genes connect disease clusters, revealing two distinct genetic architectures: one driven by ageing-related pathways and another by immune processes. Using machine learning, we also predict new candidate ageing genes associated with intracellular signalling and programmed cell death. Fantastic work by PhD student Gustavo Magdaleno 👏 link.springer.com/article/10…
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Cryonics and Cryopreservation Research Network retweeted
This is what it looks like when a “future question” becomes a real one. Cryonics is already being discussed in terms of responsibility, law and institutions — not just technology.
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Cryonics and Cryopreservation Research Network retweeted
"Being frozen is horrible. The alternative is worse." — David Ettinger, son of #cryonics founder Robert Ettinger. I interviewed him 12 years ago on cryonics, vitrification & betting on life vs death. Still one of my best conversations. 🎙️ snglrty.co/4hfV7xO
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Cryonics and Cryopreservation Research Network retweeted
Letter to SoTA: Defeating Entropy Hackathon & SoTA Debate. On 20th-22nd March, the Society for Technological Advancement (SoTA) and @LonLongevity are organising a debate on whole brain emulation and the Defeating Entropy Hackathon focused on radical life extension technologies. The “Defeating Entropy” Hackathon (21–22nd March, London) will explore frontier approaches to defeating ageing, focusing on: • Replacement — technologies to replace ageing cells, tissues, and organs (tissue engineering, neural replacement, biohybrid systems, advanced surgical tech). • Biostasis / Cryobiology — technologies to slow or pause biological processes, with applications ranging from improved organ preservation to reproductive medicine to space exploration. The SoTA Debate (20th March) will be centered on the motion: “Can Whole Brain Emulation Deliver Radical Life Extension?” Debaters: @calarsenc (@netholabs ) @danburonline (@eightsixscience, @synconeticsorg) Thank you to our partners who make this possible: @pillar_vc , @angelversetti, Klona Biotech, @fiftyyears, @tomorrowbio Read our letter (linked in the comments below) to learn more.
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Cryonics and Cryopreservation Research Network retweeted
“If nobody builds it, everyone dies” Nick Bostrom’s latest piece on artificial superintelligence makes the point that, given we are all on course for dying in (by and large) the next few decades, developing a transformative technology like AGI is worth the risk.
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Ultrastructural preservation of a whole large mammal brain with a protocol compatible with human physician-assisted death biorxiv.org/content/10.64898…

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