✝️🇹🇼🇺🇸MD/PhD candidate studying pancreatic cancer in @Chinnaiyanlab and @Lyssiotislab at @UmichMedSchool
Joined December 2019
- Tweets 917
- Following 615
- Followers 571
- Likes 2,476
68 Photos and videos
Pinned Tweet
23 Apr 2025
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
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Caleb Cheng retweeted
RESEARCH | @YatrikShahLab, H Crawford, @LyssiotisLab et al. (U of Michigan):
Disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions.
dlvr.it/TSQjRX
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Caleb Cheng retweeted
May 3
18 years. Detroit had to endure 18 years without a playoff series win. Everyone called us a fraud #1 seed.
We deserve this win!!! DEEEETROIT BASKETBALL!!!!
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Caleb Cheng retweeted
Last evening we celebrated the installation of Filip Bednar, MD, PhD as the Maud T. Lane Research Professor in Surgical Oncology. A distinguished pancreatic surgeon, brilliant researcher and highly respected teacher and mentor. Congratulations, Dr. Bednar! @Fil_Bednar @timofran1 @LyssiotisLab @Pasca_Lab
ALT Filip Bednar Professorship Ceremony
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Apr 29
Thanks for all your support @LyssiotisLab!!! 🤩👑
Apr 29
A magnificent presentation from @DJCalebC, capping off a remarkable PhD 💪🏼 GOAT status 🐐
@Chinnaiyanlab, @yuanyuan_qiao, @UMCDB, @UMICHpancreas, @UMRogelCancer
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Apr 27
24 hrs left I better finish my slides soon 🥶😬
Apr 24
My defense is in 4 days on Tuesday April 28th at 2PM!! I made an unofficial flyer and my department made an official one. Which is better?? (Btw love my committee and professors I am not scared of them)
Please feel free to join! Zoom link available by QR in the official one 😁
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Apr 24
My defense is in 4 days on Tuesday April 28th at 2PM!! I made an unofficial flyer and my department made an official one. Which is better?? (Btw love my committee and professors I am not scared of them)
Please feel free to join! Zoom link available by QR in the official one 😁
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Caleb Cheng retweeted
Unprecedented overall survival benefit from Phase 3 RASolute 302 in previously treated metastatic pancreatic cancer.
Read the press release: ir.revmed.com/news-releases/…
#Oncology #PancreaticCancer
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Caleb Cheng retweeted
Apr 13
That Phase 3 overall survival data is in second line #PancreaticCancer which makes the numbers even more astounding. I cannot recall any other example in pancreatic cancer when OS in a Phase 3 trial basically doubled over existing standard of care.
statnews.com/2026/04/13/revo…
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Caleb Cheng retweeted
Apr 13
🚨🚨🚨
RASOLUTE-302 Ph3 is POSITIVE
"Daraxonrasib demonstrated a median OS of 13.2 months versus 6.7 months for chemotherapy, with a hazard ratio of 0.40 (p < 0.0001)".... WOW!
AMAZING news for patients with #PancreaticCancer
The RAS Revolution is ON!!
ir.revmed.com/news-releases/…
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Apr 13
🔥🔥🔥Phase III results for RASolute 302 (2 L metastatic PDAC) OS 13.2 months vs 6.7 months on chemo. $RVMD
ir.revmed.com/news-releases/…
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Apr 11
Writing the acknowledgements section of my PhD thesis... So many feelings 😭😭😭
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Apr 11
saving this for my future reference as well
Apr 10
I'm not sure I've personally witnessed anyone die as well as @BenSasse.
He's set the standard in my mind for when it's my time.
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Apr 8
One of the greatest series ever
Apr 7
16 days and 4,000 kilometers later we crossed China. We ate like people in China, smoked like people in China, and spoke like absolute idiots never before seen in China.
This trip was harder than last years. Getting sick, navigating the magical 207, and failing to say the word hotel every night all the while referring to myself as “p*ssy burger” took its toll
I’m lucky to be able to do this cat line with Michael. It’s not easy to find someone you can spend everyday and every night without some tensions brewing- but I could hangout with that dude everyday until I die and never get sick of him.
A big thank you to my crew who are the only reason anyone was able to follow our journey and turn the hours of chaos into an actual series. Editors, translators, producers, fixers, assistants, designers, a dude named Li, and many more people are the reason tip2tip exists.
A special thanks to Cam, Dan, Alicia, Dave, Lucky, and Zhang Wei who followed us in an RV for 16 days <3
Finally, shoutout everyone in China the people there were unforgettably nice to two white colored foreigners riding motorcycles across China 🇨🇳😄✊
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Caleb Cheng retweeted
University of Michigan researchers @yuanyuan_qiao and @ArulChinnaiyan have identified a new target that can suppress tumor growth in gastroenteropancreatic neuroendocrine tumors.
Learn how their findings can be used to develop new treatment methods: michmed.org/VdBz7.
ALT Illustration of a vintage microscope with abstract yellow circles overlapping parts of it, set against a textured beige background.
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Caleb Cheng retweeted
Apr 7
Congratulations to @CoachDustyMay, Elliot Cadeau, and @UMichBBall on winning their first title since 1989! This team dominated the tournament from start to finish. Well deserved. Go Blue!
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Caleb Cheng retweeted
Apr 6
🚨New @LyssiotisLab paper led by Dr. Megan Radyk in @NatureMetabolism
"NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions"
🧵Follow for a tweetorial... and bonus highlight of @LabVousden co-published study and News & Views link from @WellenLab!
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Caleb Cheng retweeted
UM researchers from @LyssiotisLab identify cellular pathways that drive precancerous lesions to form pancreatic tumors.
Learn how their results could help researchers treat benign lesions before they become tumors: michmed.org/JDRQ8.
ALT Microscopic tissue images of a healthy pancreas on the left and a diseased pancreas on the right
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Mar 24
Congrats @Chinnaiyanlab !!
Mar 24
Extremely grateful and honored to receive the 2026 Harrington Prize for Innovation in Medicine from the @HarringtonDI_UH along with Dr. Charles Sawyers @SawyersLabMSKCC!
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Caleb Cheng retweeted
Mar 23
The biological rationale of targeting RAS and autophagy in combination in #PancreaticCancer is sound, the agents used are simply not tolerable. Hopefully direct RAS inhibition (versus MEK) plus newer generation autophagy inhibitors (ULK1 or PIKFyve) will have greater success.
Our phase I study tested binimetinib (BINI, MEK inhibitor) hydroxychloroquine (HCQ, autophagy inhibitor) in KRAS‑mutant, previously treated metastatic pancreatic cancer.
Rationale: dual MEK autophagy inhibition ➡️ therapeutic synergy in PDAC models (as shown by @cjder23)
@DrShubhamPant @Fen_Saj @OncJournal
academic.oup.com/oncolo/arti…
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