🚨New @LyssiotisLab paper led by Dr. Megan Radyk in @NatureMetabolism "NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions" 🧵Follow for a tweetorial... and bonus highlight of @LabVousden co-published study and News & Views link from @WellenLab!

The House Appropriations Committee passed its version of the FY27 spending bill, including an increase of $110 million compared to the current year’s budget for @theNCI 👏🏽👏🏽 From @TheCancerLetter cancerletter.com/capitol-hil… The Senate will now take up its version of appropriations.

Very nice resource paper in @Cancer_Cell that enables correlation of cell type specific expression data with survival in #PancreaticCancer. cell.com/cancer-cell/fulltex… Takes TCGA type datasets based on bulk RNA to the next level. Interactive web tool (ctPANDA) allows facile queries.

Great representation from our pancreas cancer researchers! @Pasca_Lab @Fil_Bednar @timofran1 @ABischoff17

For a variety of reasons, we’ve been quantitating many western blots & radioactive protein gels so made this app for doing so as unhappy with what is available. Can quickly quantitate gels/blots & make simple graphs from the data. Instruction tab in app. dms-western-blot-analyzer.ne…

Congratulations @CNuevoTapioles & Mark Philips @nyugrossman @Perlmutter_CC Beautiful work in @CellReports showing the mechanistic underpinning of how KRAS upregulates glycolysis. sciencedirect.com/science/ar…

Another successful Moses Gunn Research Conference is in the books! On Friday, faculty, residents, medical students and others came together to celebrate the incredible breadth of research happening in the department. Highlights from the day: michmed.org/3WVyg

There are now 710,082 total living alumni of the University of Michigan. 〽️

A patient came to the Rogel Cancer Center looking for answers to treat her rare neuroendocrine tumor. Alongside a multidisciplinary care team, Evan Glazer, MD, PhD, came up with a personalized treatment plan. The full story: michmed.org/9ZkwP

Excited to share our new paper out today in @NatureMetabolism! "Hyperglycosylation is a metabolic driver of Alzheimer’s disease" *We bridged spatial metabolomics (MALDI-MSI glycomics lipidomics isotopic pulse-chase tracing) directly to experimental biochemistry (genetic knockdown of glycan enzymes glucosamine supplementation in AD models) and real-world public health data (EHR analysis showing glucosamine use linked to faster MCI-to-AD progression and worse survival). **Key takeaway: The AD brain shows conserved hyperglycosylation driven by ramped-up glycan biosynthesis — not just a byproduct, but a causal driver. Reducing it helps cognition; boosting it (e.g., via glucosamine) worsens outcomes. ***We applied cutting-edge spatial tech to functional validation and clinical translation. Full open-access paper: nature.com/articles/s42255-0… Huge thanks to the incredible team, collaborators (incl. Matt Gentry, Stefan Prokop, @ji0ngbi0n , Yi Guo, @lichenbiostat, Ralph Deberardinis & others), and the patients/families who make this work possible.

Very cool study by @rushika_perera lab uncovers the mechanisms of autophagic degradation of MHC-I to achieve immune masking of PDAC cells

I am holding my breath. There are real health concerns and liabilities here.

The first participant to receive partial cellular reprogramming for eye disease (advanced glaucoma) in a pilot study of 12 patients was treated. Using 3 of the 4 Yamanaka stem cell factors to potentially achieve cellular rejuvenation @Nature nature.com/articles/d41586-0…

And plans to do this at the whole-body level @techreview What could go wrong? Inducing cancer, for one. technologyreview.com/2026/06…

More good news in pancreatic cancer: Daraxonrasib recently doubled survival in metastatic disease in Phase 3. Now, combined with vopimetostat, it has shown a 92% objective response rate. This is far above the 25–35% seen with either drug alone. Thread below 👇

GLP-1 drugs in people with obesity (no diabetes) and the link to reduction of cancer Among nearly 230,000 individuals, there was >40% overall reduction in 13 cancers associated with obesity with just 2 years of follow-up. Not proof of cause and effect, but consistent with many recent reports on the link between GLP-1 drugs with less cancer annalsofoncology.org/article…

Data from Tango slide deck of PRMT5inh plus KRASinh (Daraxonrasib, left and Zoldonrasib, right) in 2nd/3rd line #PancreaticCancer ir.tangotx.com/static-files/… In this recent study (Boston Gene), ~20% of pancreatic cancers have KRAS mut plus MTAP co-deletion. aacrjournals.org/clincancerr…

Important Request for Information (RFI) from @NIH “Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator to Support More Researchers and Maximize Scientific Productivity and Innovation” grants.nih.gov/grants/guide/… Some suggested caps & impact:

Special congratulations to the Frankel Lab! Drs. Frankel and Griffith are so deserving! @timofran1 @BGriffithMD

Cell death (and even senescence) this month! - Bcl-XL inhibition targets neutrophils - activation of caspase-3 by non-canonical inflammasomes - ferroptosis is immunosuppressive in cancer models (@LyssiotisLab ) - Inflammatory consequences of dead cells ... celldeath.wordpress.com/2026…

Congrats to @UMPhysiology PhD student @ChestaJain5 and the @YatrikShahLab for her paper in @Cell_Metabolism demonstrating that colorectal cancer cells, which use lots of iron, can survive normally toxic iron levels through altered metabolism. sciencedirect.com/science/ar…