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Trader Lab @DJTraderLab

Medicinal Chemistry and Chemical Biology Lab @ UC Irvine

Joined March 2018
  • Tweets 392
  • Following 256
  • Followers 727
60 Photos and videos
Please join us to learn more about applying for a PhD in PharmSci at UCI! uci.zoom.us/meeting/register…
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New degrader paper using the immunoproteasome and degrons! Congrats Cody Loy and Timothy Harris! pubs.acs.org/doi/full/10.102…

Degradation of Abl Utilizing an Immunoproteasome N-Degron Prodrug

Targeted protein degradation is an emerging therapeutic strategy that leverages the cell’s natural protein clearance pathways to eliminate proteins of interest (POIs). One common approach involves...

pubs.acs.org
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Trader Lab retweeted
Keriann Backus@Keribackus
24 Oct 2024
Thrilled to share our new study in @nchembio describing the proteome-wide impacts of electrophile stress in the context of covalent fragments. Big congratulations to first authors Ashley Julio @AshleyJulio4 and Flowreen Shikwana @FShikwana ! 1/5 nature.com/articles/s41589-0…

Delineating cysteine-reactive compound modulation of cellular proteostasis processes

Nature Chemical Biology - A cysteine-reactive degrader of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 14 (nsp14) was identified, which mediates degradation...

nature.com
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Trader Lab retweeted
Nature Chemical Biology@nchembio
16 Oct 2024
A new paper from @TheAlbrecht_Lab and @LJSeabrook developed a targeted protein degradation platform, MrTAC, that enables arginine methylation-driven degradation of intracellular proteins in lysosomes doi.org/10.1038/s41589-024-0…
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Trader Lab retweeted
Laurence Seabrook@LJSeabrook
16 Oct 2024
I’m so excited to welcome MrTAC to the world of targeted protein degradation! We created a chemical inducer of arginine methylation that can be used to degrade proteins in lysosomes 💊 So grateful for everyone involved in this project 🥳🥳 nature.com/articles/s41589-0…

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins

Nature Chemical Biology - Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins...

nature.com
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Congrats Cody and Saayak on your immunoproteasome probe paper! chemistry-europe.onlinelibra…

Synthesis and Application of a Versatile Immunoproteasome Activity Probe

The ONX-0914-alkyne probe described here allows for the conjugation to a variety of fluorophores through click chemistry. It can then be used to visualize immunoproteasome activity in gel-based,...

chemistry-europe.onlinelibrary.wiley.com
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Excited to see this happening. Go proteasome stimulation!!! linkedin.com/posts/feleciano…

#biotech #biotechinnovation #proteasomeactivation #neurodegenerativedisease | Diogo R. Feleciano |...

Introducing Booster Therapeutics! I’m very proud to announce the debut of Booster Therapeutics 🚀 With $15M in seed financing from Apollo Health Ventures and Novo Holdings, we are pioneering a new...

linkedin.com
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UC Irvine’s Pharmacological Sciences PhD Program is hosting a VIRTUAL Info Session on Wed, Sept 11 from 12 pm – 1 pm PST. Join us to learn about the Pharmacological Sciences PhD Program, the Admission process, and helpful campus resources. Register: bit.ly/3XhrGTD
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Congrats @CodyLoy45 on your RSC ChemBio paper on a caged luciferin probe for the immunoproteasome! doi.org/10.1039/D4CB00148F

Caged aminoluciferin probe for bioluminescent immunoproteasome activity analysis

The immunoproteasome (iCP) can be expressed under inflammatory conditions, such as exposure to interferon-gamma (IFN-γ), that alerts the cell to begin generating iCP preferentially over the standard...

pubs.rsc.org
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Congrats @CodyLoy45 on your recent review on the proteasome's primed substrate channel! doi.org/10.3390/molecules291…

Primed for Interactions: Investigating the Primed Substrate Channel of the Proteasome for Improved...

Protein homeostasis is a tightly conserved process that is regulated through the ubiquitin proteasome system (UPS) in a ubiquitin-independent or ubiquitin-dependent manner. Over the past two decades,...

mdpi.com
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Trader Lab retweeted
Cody Loy@CodyLoy45
14 Jun 2024
Had an amazing experience at my first Bioorganic Chemistry GRC! From the exciting talks to making some incredible friendships, I can’t wait to go back to science summer camp. 🧪🏕️ Oh, and winning an outstanding poster award wasn’t too bad either!
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Huge congrats to these FIVE amazing PhD candidates in the lab! Cody Loy, Kate Kragness, Tim Harris, Duno Dantis, and Jaida Osman
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Dr. Donna Huryn@DMHuryn
28 May 2024
We have an opening for a #chempostdoc in the @DMHuryn lab to work on our med chem / chemical biology kidney disease project. For more info - and contact info: web.sas.upenn.edu/hurynlab/

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Discover the secrets to PhD success! 🥼🔬 Listen to @TheAlbrecht_Lab on her tips to becoming a successful PhD student at @UCI_SPPS. #UCISPPS #UCIPharmSci #FuturePhD #PhDStudent #GradSchool
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Congrats Candidate Cody!
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Laura Kiessling@ChemicalBiology
3 Apr 2024
The @OnoPharmaFound sponsors a terrific series of Webinars in #chembio and this upcoming one will be excellent. Please retweet to get the word out.
ONO PHARMA FOUNDATION@OnoInitiative
13 Mar 2024
Join us for the 8th #chemicalbiology webinar featuring Dr. Michelle Arkin (UCSF), who will present on "Molecular glues for 14-3-3sigma/CRAF as potential probes and drugs for Noonan’s Syndrome" Apr 17, 4:30PM-5:30PM PT, Zoom For free registration, visit onofound.org/events/michelle…
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When your trainees have too much time on their hands, they make your lab into proteasome people!
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Trader Lab retweeted
Wendt Lab@WendtLab_cancer
20 Mar 2024
The wendtlab.com/ is looking for postdocs interested in collaborative work in breast cancer metastasis, novel therapeutics, and the tumor microenvironment. @uiowa @UIowaCancer @IntMedatIowa offer a great environment of translational research. rb.gy/yfonfc
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Looking forward to our session today 2-5pm in Room 356! Targeting Protein Homeostasis Networks and Recent Developments Towards Targeting the Proteasome with Small Molecules #ACSSpring2024 @DMHuryn
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Trader Lab retweeted
Lyn Jones@LynJonesChemBio
14 Mar 2024
We are looking for a postdoctoral research fellow to work with Eric Fischer and myself to pioneer next-generation covalent drug discovery. Please retweet. Apply here: careers.dana-farber.org/jobs… @fischerlab1
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