Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq
A UC Irvine-led research team showcases how the use of methylarginine targeting chimeras controls the body’s protein degradation pathway. This method signals a new approach to developing drugs that can more effectively treat disease. Read the full story: bit.ly/3QIhqEr
We’re proud to share that Dr. Lauren Albrecht has been promoted to tenured Associate Professor at UC Irvine!
Join us in congratulating Professor Albrecht on this significant milestone and her contributions to our academic community, school, and students! @TheAlbrecht_Lab
RESEARCH | M Campos, LV Albrecht et al. (UC Irvine)
Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.
nature.com/articles/s42255-0…
Honored to have our latest MrTAC research article featured on the Cover of Cell Chem. Here, we develop the first endogenous MrTAC and decode the rules of protein degradability, expanding tissue-specific degrader modalities.
Thanks to @NatureSMB for publishing a "Research Briefing" on our recent work, highlighting the discoveries and providing context on the story behind our research into how vitamin B2 metabolism regulates FSP1 stability to suppress ferroptosis.
1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
nature.com/articles/s41594-0…
A mitochondrial transport protein promotes carnitine synthesis in mice when fat consumption is needed.
Learn more in a new #SciencePerspective: scim.ag/4bWnC4h
PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington’s Disease | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
📣 First preprint from the TeSlaa lab 📣 We investigated how methyl-rich nutrient, choline, is used in the body and how systemic one-carbon metabolism responds to dietary methyl-donor deficiency.
biorxiv.org/content/10.64898…
Dr. Suzann Duan has received a $45,000 American Cancer Society Institutional Research Grant (ACS-IRG) Seed Grant Award to improve strategies to prevent or treat neuroendocrine tumors. Read more: pharmsci.uci.edu/2026/02/12/…