Group Leader, University of Minnesota Genomics Center Innovation Lab. Founder, CoreBiome (now Diversigen).
Joined May 2015
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39 Photos and videos
READ: “High-throughput genetic manipulation of multicellular organisms using a machine-vision guided embryonic microinjection robot.” Alegria et al. @NSF (ORIP support through 1R21OD028214, 1R24OD028444)
academic.oup.com/genetics/ar…
ALT Issue Cover: April 2024
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New paper in our lab led by Andrew Alegria and @Amey__Joshi published in @GeneticsGSA . Fun collab with @DarylGohl and Bischof group @umnme @UMNCSE We also made it to the cover! academic.oup.com/genetics/ar…
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Daryl Gohl retweeted
3 Apr 2024
On the cover of the April issue of GENETICS: An automated microinjection of Drosophila embryos by a computer vision-guided robot. Alegria et al. present a machine vision guided generalized robot that automates the process of microinjection in fruit fly and zebrafish embryos.
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ALT Automated microinjection of Drosophila embryos by a computer vision-guided robot.
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🚨 New pre-print alert!🚨 Led by the brilliant, twitter-less post-doc James Hope. We built a 🤖 exoskeleton for 🐭🐁 so we can study their 🧠's as they go around navigating their world. An e.g., imaging 1000s of neurons in the cortex when mice walk an 8-maze. A 🧵
7 Jun 2023
Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton biorxiv.org/cgi/content/shor… #bioRxiv
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Daryl Gohl retweeted
27 Apr 2023
I am really excited to share that our new pre-print on “A machine vision guided robot for fully automated embryonic microinjection” is out. Thanks to @AndrewAlegria37, all collaborators and @bksuhasa @DarylGohl
🚨🚨 New pre-print alert! A fun collaboration involving 🤖s, fruit🪰s,🐠, and 🧬 with @DarylGohl. Co-led by twitterless Andrew Alegria and @Amey__Joshi . A generalized machine vision guided robot for microinjections into whole intact embryos. biorxiv.org/content/10.1101/… (1/n)
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26 Apr 2023
Really excited to share this new preprint on automated microinjection of Drosophila and zebrafish embryos! See this thread by our collaborator @bksuhasa
🚨🚨 New pre-print alert! A fun collaboration involving 🤖s, fruit🪰s,🐠, and 🧬 with @DarylGohl. Co-led by twitterless Andrew Alegria and @Amey__Joshi . A generalized machine vision guided robot for microinjections into whole intact embryos. biorxiv.org/content/10.1101/… (1/n)
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26 Apr 2023
We also trained a separate machine learning model and used the same robot to successfully inject zebrafish embryos and believe that this robotic system can be readily generalized to carry out automated microinjection in many other species. (9/10)
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26 Apr 2023
This work was led by two amazing grad students, @Amey__Joshi and @AndrewAlegria37, with critical contributions from @sciberius and Jorge Blanco Mendana (not on Twitter). Many thanks to all our co-authors! (10/10)
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Daryl Gohl retweeted
24 Oct 2022
New paper! It’s absolutely wild what you see when studying bacteria using single-cell RNA-Seq! Unlike in eukaryotes, we found a genome-scale pattern of correlations among genes showing a strong dependency on global chromosomal locations.
biorxiv.org/content/10.1101/… @AndrewPountain
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Daryl Gohl retweeted
10 Oct 2022
What if you could image 🔬cells and then choose which ones to sequence 🧬?
What if you could go back and image 🔬cells that you previously sequenced 🧬?
Now you can 🔬 then 🧬 then 🔬 cells again with Light-Seq!
nature.com/articles/s41592-0…
Let’s dig in 🧵.
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Daryl Gohl retweeted
5 Oct 2022
Our ADAR-based RNA sensors just came online! rdcu.be/cWX7o It allows you to express protein payloads in live cells in direct response to the presence of specific RNA transcripts. Also @EerikKaseniit, welcome to twitter.
2 Feb 2022
As we work towards DNA-free circuits, we realized we could use some new RNA sensors in living cells. So we built RADAR biorxiv.org/content/10.1101/… Congrats to Eerik, @katznoa1, @NatalieSKolber, @claytoncalli, and thanks to our plant biologist neighbors, Diego, Will, and @Sattely_lab
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Daryl Gohl retweeted
4 Oct 2022
Check out our new preprint on the after-life of intestinal cells: biorxiv.org/content/10.1101/…. Cells that are shed each day from our gut are thought to die immediately upon their dissociation from the tissue. Here we show that this is not the case (1/6).
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