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De Schutter OIST Lab @DeschutterOIST

Computational neuroscience: nanoscale modeling of neurons, astrocytes and synapses, Purkinje cell

Joined August 2021
  • Tweets 45
  • Following 23
  • Followers 371
19 Photos and videos
Last post on X. Follow the OIST Computational Neuroscience Unit on deschutteroist.bsky.social/
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Because of the toxic atmosphere on X I am migrating to the blue skies… Same handle.
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Looking for for a postdoctoral researcher or technician to contribute to the software development of the nanoscale simulator of neuronal electrophysiology and molecular properties STEPS steps.sourceforge.net/STEPS/…. Experience in C & Python required. Mail erik@oist.jp if interested.
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Great new preprint on our modeling of astrocyte electrophysiology! We show that small K increases combined with glutamatergic activation of a few NMDA receptors can locally depolarize perisynaptic astrocytic processes by 20 mV and trigger K outflow. biorxiv.org/content/10.1101/…
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Preprint from collaboration with Justin Lee where we use modeling of granule cell tonic inhibition at different ages to predict maturation of motor skills in mice biorxiv.org/content/10.1101/…
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Paper describing our cool vesicle spatial and molecular modeling technology is now out at nature.com/articles/s42003-0… Software available at steps.sourceforge.net/STEPS/…
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A postdoctoral position is available in the Computational Neuroscience Unit (groups.oist.jp/cnu) of Prof. Erik De Schutter erik@oist.jp at the Okinawa Institute of Science and Technology for a researcher interested in modeling cerebellar properties and function.

Computational Neuroscience Unit (Erik De Schutter)

Go to the new website 新しいサイトへ

groups.oist.jp
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Novel Purkinje cell model with heterogenous ion channel densities has more uniform dendritic properties than the Zang and De Schutter 2018, 2021 model. CaP and Kv4 channels can largely compensate for morphological differences between dendritic branches. biorxiv.org/content/10.1101/…

Branch-specific clustered parallel fiber input controls dendritic computation in Purkinje cells

Most central neurons have intricately branched dendritic trees that integrate massive numbers of synaptic inputs. Intrinsic active mechanisms in dendrites can be heterogenous and be modulated in a...

biorxiv.org
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Okinawa/OIST Computational Neuroscience Course 2024 (OCNC 2024): Apply now! This unique summer course supports students to develop their own research project in computational neuroscience. groups.oist.jp/ocnc
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The Okinawa Institute of Science and Technology is recruiting new faculty in all areas of science, with a special interest in junior (female) computational neuroscientists. Experience a new model of scientific freedom in an innovative university! Info at groups.oist.jp/facultypositi…
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Review paper “Recent data on the cerebellum require new models and theories” with Yunliang Zang is available online. Challenging times for cerebellar theory! sciencedirect.com/science/ar…
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Preprint of our model of the complete synaptic vesicle cycle in a realistic hippocampal en passant bouton in unprecedented molecular and spatial detail thanks to the revolutionary new fully spatial and dynamic vesicle modeling technology we developed. biorxiv.org/content/10.1101/…
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Two papers out: first detailed model of early cerebellar development with simultaneous granule cell migration and Purkinje cell dendrite development journals.plos.org/ploscompbi… and the Neural Development Simulator software used frontiersin.org/articles/10.…. Need more experimental data!

Models of Purkinje cell dendritic tree selection during early cerebellar development

Author summary The mature structure of a Purkinje cell, the main neuron of the cerebellum, is composed of a large flat dendritic tree composed of a single or sometimes two primary dendrites. However,...

journals.plos.org
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De Schutter OIST Lab retweeted
Ellender Lab@TommasEllender
17 May 2023
📢 #jobopportunity 📢 Interested in brain development? Come join the lab in beautiful Antwerp! We have a #vacancy for a 3-year fully funded postdoc position🧠. For info ℹ and procedure: 👉tinyurl.com/yma8pbc5 📅 Application #deadline: 29 June 2023
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We’re proud to announce this new preprint describing our cool hybrid vesicle modeling technology. biorxiv.org/content/10.1101/…
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De Schutter OIST Lab retweeted
Sungho Hong@sungho_hong_
4 May 2023
Finally out! A landmark in our quest to understand cerebellum's role in coordinating movement and learning new coordination. Exciting developments ahead! Grateful to co-authors @AkshayMarkanday, Junya Inoue, @erik_deschutter (@DeschutterOIST), & Peter Thier.
New neuroscience papers in Nature Communications@NeuroPaperBot
3 May 2023
Multidimensional cerebellar computations for flexible kinematic control of movements ift.tt/kDFrN6T
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PhD students and postdocs can apply to join the 2023 Okinawa/OIST Computational Neuroscience Course at groups.oist.jp/ocnc
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New paper in eLife with Sergio Verduzco-Flores: Self-configuring feedback loops for sensorimotor control. A biologically constrained model that learns limb control in a few minutes by adapting the strength of motor cortex to spinal cord synapses. doi.org/10.7554/eLife.77216
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De Schutter OIST Lab retweeted
EPFL Blue Brain Project@BlueBrainPjt
31 Oct 2022
When attempting complex large-scale simulations, dedicating more computing power to the problem is good but not enough. Discover how the boundaries of biochemical diffusion-reaction models were pushed to the scale of entire neurons👇 actu.epfl.ch/news/steps-40-t… #Neuroscience #HPC
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De Schutter OIST Lab retweeted
Audrey Denizot@ADenizot
14 Sep 2022
Delighted to announce that our paper investigating the effect of the nanoscale morphology of astrocytes on Ca2 activity at synapses is out in @GLIA_Journal! Great interdisciplinary collaborative work with @NagerlL & @DeschutterOIST. #Astrocytes #Glia onlinelibrary.wiley.com/doi/…
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