Author, The Ultimate Asset: a.co/d/hUjS9AU. Physician, CEO & Founder @join_velocity ex- @harvardmed @mayoclinic

Joined December 2021
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We’re officially live! Get The Ultimate Asset here Your playbook for how to dominate midlife and beyond a.co/d/hUjS9AU
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Sandeep Palakodeti, MD MPH retweeted
TOMORROW IS THE DAY! Eric Hinman, 5x Ironman, goes LIVE with his Velocity PRO clinical team lead by @DrDeepMD to talk about his training for the HYROX World Championship in Stockholm, Sweden. They’ll be walking through the full slate of tests Velocity PRO offers to close the gap between performance and health: -Cleerly CCTA heart scan -Springbok MRI -DUTCH hormone panels -NutrEval nutritional diagnostics -Onera At-Home sleep study -And many more In a time when athletes push themselves harder then ever, we make sure they have the health to handle the demand.
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Sandeep Palakodeti, MD MPH retweeted
Dear US government, Since you've just blocked Fable and Mythos on critical national security grounds, here are some other tools that pose a similar threat to the American people: - Microsoft Teams - SAP - Salesforce - Jira - Outlook Please do what you must to save America 🇺🇸
‼️🚨 BREAKING: Amazon researchers snitched to the US government about jailbreaking Fable 5 and Mythos 5, forcing Anthropic to immediately shut down worldwide access. A security export control directive from Commerce Secretary Howard Lutnick enforced the action. Anthropic is fighting the directive and calls it a misunderstanding. This isn't the first clash. The Trump administration had already tried to get Anthropic to pause the release of its latest models before this directive landed.
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Sandeep Palakodeti, MD MPH retweeted
THE PEPTIDE KING RETURNS You’re probably doing peptides wrong. In Anthony Castore’s return to The Ultimate Asset Podcast to he goes over all the mistakes he’s made, and tells you how to not do the same. Watch as he sits down with @DrDeepMD and @brocktreichert to help you get the most value out of your peptides, and stay safe while doing it. 📺 YouTube: youtu.be/tOk8eX5F2Hw?is=rtKE… 🍎 Apple: podcasts.apple.com/us/podcas… 🎵 Spotify: open.spotify.com/episode/6GT…
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Alright y'all, HERE IT IS I know everyones talking about the *other* one out right now, but IMHO, this is absolutely the most comprehensive, detailed, and in-depth discussion on peptides I've ever heard Anthony Castore is truly one the MOST knowledgeable peptide specialists in the world Take a listen to The Ultimate Asset, like, share, and please give us your feedback
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Entrepreneurship is being told 1,000 “no’s” and “you’ll nevers” over and over and over again And still doing it anyway Because there’s some small part of you that keeps coming back and saying “it just takes one” And then the next. And the next. Keep going
> you’ll never start a rocket company > you’ll never build your own engines > you’ll never be able to use off-the-shelf parts > you’ll never survive three launch failures > you’ll never reach orbit > you’ll never win NASA’s trust > you’ll never launch cargo to the ISS > you’ll never compete with Boeing > you’ll never compete with Lockheed > you’ll never make rockets reusable > you’ll never land a rocket vertically > you’ll never land one on a drone ship > you’ll never reuse a booster > you’ll never fly the same booster 10 times > you’ll never fly the same booster 20 times > you’ll never fly the same booster 30 times > you’ll never recover and reuse the fairing > you’ll never lower launch costs > you’ll never launch every month > you’ll never launch every week > you’ll never launch multiple times a week > you’ll never carry astronauts > you’ll never replace Roscosmos > you’ll never fly civilians to orbit > you’ll never manufacture satellites at scale > you’ll never build the biggest constellation ever > you’ll never make satellite internet work > you’ll never make satellite internet fast > you’ll never make satellite internet affordable > you’ll never serve rural customers > you’ll never serve aircraft and ships > you’ll never build a methane rocket engine > you’ll never make full-flow staged combustion work > you’ll never build the most powerful rocket ever > you’ll never build a rocket bigger than Saturn V > you’ll never build it out of stainless steel > you’ll never launch Starship > you’ll never separate Super Heavy and Starship > you’ll never relight Raptor in space > you’ll never bring Super Heavy back > you’ll never catch a booster with Mechazilla tower arms > you’ll never launch 85% of mass to orbit worldwide > you’ll never change the economics of space > you’ll never force the entire industry to copy you > you’ll never win > you’ll never IPO   Congratulations to @elonmusk and the SpaceX team. You did what countless people said was impossible, and you did it time and time again.   Today is your day. You deserve this. May it be a glorious one.
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Sandeep Palakodeti, MD MPH retweeted
Everyone asks which GLP-1 to take. Almost no one asks whether their body is ready for one. The Peptide King, Anthony Castore, breaks it down in his return to The Ultimate Asset: a stressed, sleep-deprived system is already flooding the bloodstream with cortisol and sugar. Add a GLP-1, and you can make the problem worse. The fix is the order you do things in.
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What I love about Anthony’s approach: he builds the structure before he lets in the signal. Most people I see go the other way. They stack compound after compound onto a body that’s already depleted and inflamed, then wonder why nothing works. You could send the perfect signal into a cell, but if it’s too loud, your body won’t hear it.
A peptide is a signal, but a signal only works if the body can hear it. By doing too much at one time, it’s like having a conversation where everyone is talking all at once. Anthony Castore, the peptide king, returns to The Ultimate Asset to explain why structure comes before the stack.
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Sandeep Palakodeti, MD MPH retweeted
A peptide is a signal, but a signal only works if the body can hear it. By doing too much at one time, it’s like having a conversation where everyone is talking all at once. Anthony Castore, the peptide king, returns to The Ultimate Asset to explain why structure comes before the stack.
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Sandeep Palakodeti, MD MPH retweeted
Insane advice from Fable 5
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This is the best guidance I give to aspiring med students as well Medicine’s knowledge base will be democratized. But it’s the JUDGMENT that truly defines a good doctor. We all have access to open evidence and pubmed How you synthesize and make decisions is the true moat
Incredible advice from Claude on what to study in college today
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Anthony Castore “The Peptide King” is BY FAR (by a lot) the most knowledgeable person I have ever talked to or listened to on the topic I know what you’re all thinking Yes, he is. Literally. This will be one of those podcasts that just blow your mind Coming to you Saturday!
Peptides might be the most hyped, least understood molecules in health right now. So The Ultimate Asset brought back the guest who explains them best. Anthony Castore, the peptide king, returns.
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Sandeep Palakodeti, MD MPH retweeted
If a 5x Ironman can have nutritional deficiencies, where does that leave the average athlete? Meet Eric Hinman; a 5x Iron Man and HYROX Pro. His labs came back green across the board. Training dialed, clean diet, and a supplement stack most would call overkill. Every marker optimal, except one. And it was the kind of imbalance that undercuts recovery.
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Sandeep Palakodeti, MD MPH retweeted
What you're looking at is the inside of a real human heart, captured in 20 minutes with no incision. It's called a Cleerly CCTA. And it shows the cardiac risk a normal physical and EKG were never built to catch.
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Good question: does added sugar drive accelerated aging in older adults, and cause endocrine disruption in developing teens? YES and YES. Here’s how: For older adults (40s ish and up) excess added sugar acts like an accelerator on the aging process. We already deal with inflammaging (baseline chronic low grade inflammation that comes with getting older) but sugar pours gas on that fire It drives advanced glycation end products that cross-link collagen and elastin in your skin, blood vessels, and tissues. We call it “sugar sag”: stiffness, faster wrinkles, worn out look It also spikes oxidative stress, insulin resistance, and epigenetic changes that make your biological age pull ahead of your chronological one with telomeres shortening faster, and mitochondrial function taking massive hit On the kids and adolescent side, their endocrine systems are still developing and incredibly sensitive. Added sugar isn’t a classic toxin like phthalates or BPA (which also play into all of this), but it does function as a potent endocrine disruptor anyway It causes repeated insulin and IGF-1 spikes that mess with the signals controlling growth and puberty timing. I’m seeing more signals of central precocious puberty in the data and my own eyes, especially in girls, but it plays out in opposite way in boys (too much estrogen). High fructose intake during these critical years can reprogram liver metabolism, fat storage, glucose handling, and the gut microbiome in sex specific ways that stick with them into adulthood We’re quietly shifting metabolic set points and hormone sensitivity at the population level during the exact window when the body is calibrating for the rest of life These effects are also dose dependent and sometimes independent of total calories or obesity. The ultra processed foods loaded with added sugar make it worse because of the glycemic load and the whole pro inflammatory package w these “foods” Most major guidelines already say keep added sugar under 25 grams a day (roughly 6 teaspoons). We need to replace sweetened drinks, hidden trash in “healthy” snacks, and the obvious desserts most days If you have kids, follow your own advice: protein first meals, whole foods, movement, sleep, and sunlight Much work to do in our environment and general consumption. But start w the basics, and stop subjecting our children and ourselves to the disruption of our biochemistry that is fundamentally shifting aging
Replying to @DrDeepMD
هل ترك السكر المضاف له دور في ذلك؟
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Aging, from my lens, has become an increasingly weird phenomena I regularly talk to 45-50 year olds (mostly men) who genuinely look like they 65-70. I deal with people all day so I have a good barometer. I’m often just shocked and have to double check the DOB On the other end, the 25 year olds (mostly men) look like they are 16. Actual baby faced teenagers who should be looking like prime aged men The underlying inflammation and endocrine disruption are completely changing our phenotypes Much work to do
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To all your entrepreneurs out there For every day you think to yourself "is this shit ever going to work? are we actually going to make it?" Just keep pushing. With enough persistence and enough shots on goals, there will come a day where it becomes "holy eff this is massive"
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Sandeep Palakodeti, MD MPH retweeted
Eric is one of the fittest humans alive and still had biological gaps capping his output. If that's true for a 5x Ironman, it's true for the rest of us. He didn't break through by training harder. He did it by seeing his own data. Comment PRO in the post below for the webinar link and I'll see you on the 15th.
Are you training harder than ever but still hitting a performance plateau? Most dedicated athletes assume they just need to put their head down and push through the fatigue. In reality, hidden biological gaps are likely stalling your recovery, throwing off your hormonal balance, and capping your power output. If you want to maximize your training, you need to find out whats hurting your performance at a cellular level instead of just relying on generic advice. On Monday June 15th at 8 PM EST, Velocity Health is hosting a live webinar breaking down the exact clinical strategy behind elite athletic preparation. You will hear directly from five time Ironman competitor Eric Hinman, former Mayo Clinic physician Dr Sandeep Deep Palakodeti, and Chief of Clinical Operations Brock Reichert. We will reveal how we used advanced diagnostics to eliminate guesswork from Erics protocol for the HYROX World Championship, covering everything from managing systemic physical stress to optimizing oxygen delivery and cellular energy. This is your opportunity to audit your own approach, understand your baseline data, and discover exactly what is holding your body back from its true potential. Due to live room limitations, we have only 100 spots available for this broadcast. To secure your seat before the room fills up, comment the word PRO below and our team will instantly send the private registration link directly to your messages.
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It’s not crazy to say that we’ll all have access to the worlds most advanced diagnostics, in each of our homes, for less than the price of an average car note
There's a startup in the current YC batch that built an MRI machine in 101 days.
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This is really the best travel advice there is No reason to shove airport slop down the gullet Use it as a meditative day of fasting while you soar through the skies & go look up the dirtiest places on airplanes, the whole mask fiasco will be laughable & dont drink the water
Dana White’s jet lag hack is wild. He fasts the entire long flight (he already does intermittent fasting) and drinks hydrogen water the whole way. He’s done it to Australia, Abu Dhabi, and New York, and says he gets zero jet lag. He’s so into it he just bought a bigger hydrogen water machine. Fasting during travel helps reset circadian rhythms by aligning meal timing with the destination’s local time, reducing jet lag symptoms. Molecular hydrogen (in hydrogen-rich water) acts as a selective antioxidant, reducing oxidative stress and inflammation caused by high-altitude flight conditions, which may further aid recovery and energy levels. Jet lag ruins travel. If this combination really works, it’s a simple, low-cost hack for frequent flyers. Have you tried fasting on long flights before?
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