In ECCO, we work to engage early-career scientists in the complement field. We share information about science, job ops, fellowships and social activities.
Joined August 2018
- Tweets 1,850
- Following 171
- Followers 380
- Likes 3,136
122 Photos and videos
ECCO retweeted
17 Nov 2025
Please join @EccoComplement this Thursday, Nov 20, for our free online seminar, “New Methods and Techniques in Complement Research.” Early-career complement scientists will be presenting a range of research techniques. All are welcome! Register here: complement.org/event-6410862
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7 May 2025
PAPER OF THE WEEK! (1/4) This week’s paper by Prasad et al. explores how the complosome drives metabolic and inflammatory changes in vascular fibroblasts in pulmonary hypertension (PH)...
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7 May 2025
PAPER OF THE WEEK (4/4) Every week, ECCO highlights a new & exciting research article about the complement system. We strive to promote the work of early-career scientists. Did you recently publish a paper relevant to the complement field? Submit your work and we will promote it!
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7 May 2025
PAPER OF THE WEEK (3/4) These findings highlight intracellular complement activation as a potential therapeutic target for PH management. Read the full text here: insight.jci.org/articles/vie…
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7 May 2025
PAPER OF THE WEEK (2/4) The authors found that PH fibroblasts exhibit elevated expression of complement proteins (C3, CFD, CFB), which promote mitochondrial dysfunction, metabolic reprogramming, and pro-inflammatory signaling.
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11 Mar 2025
📢 Attention Complement Biologists!! The abstract and travel award deadline for ICW2025 has been extended to April 14! There are many great travel awards available for Early Career Researchers! Register and find more information here 👉 complement.org/icw-2025
@ComplementSoc
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10 Mar 2025
Congratulations to February's ECCO Scientist of the Month, Dr. Marie-Sophie Meuleman! Marie-Sophie studied for an MD in Nephrology at the Université Paris Cité and a PhD in Immunology at Cordeliers Research Center in the lab of Prof. Cremer. (1/4)
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10 Mar 2025
Marie-Sophie would like to share her recent publication in which she focused upon both the activation of the terminal complement pathway and the intrarenal immune response in C3 glomerulopathy. Find it here! 👇 (3/4) pubmed.ncbi.nlm.nih.gov/3870…
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10 Mar 2025
Marie-Sophie was introduced to complement during her master’s degree where she studied complement activation by monoclonal immunoglobulins under the supervision of Sophie Chauvet. C3 is her favourite complement protein because “without it nothing would be possible!”. (2/4)
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ECCO retweeted
28 Feb 2025
Genetic variants in C3 and FH play a crucial role in determining renal outcomes post-transplantation - perhaps this indicates a genetic-mediated tailoring of treatments? #complement #allograftrejection #kidney
buff.ly/4182roF
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ECCO retweeted
17 Feb 2025
Excited to be hosting the International Complement Workshop in Brisbane! Join us from Sept 14th-19th for cutting-edge complement science and unique Australian experiences. Submit abstracts by March 14! More info: complement.org/icw-2025 #ICW2025 #ComplementScience #Complement
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4 Feb 2025
PAPER OF THE WEEK (1/4) This week's paper by Chi et al. explores C3-C3aR-mediated astrocyte-neuron communication in Parkinson’s disease (PD). They found that complement C3 colocalizes with astrocytes in the CNS, with expression regulated by TLR2 and NF-kB.
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4 Feb 2025
PAPER OF THE WEEK (4/4) Every week, ECCO highlights a new & exciting research article about the complement system. We strive to promote the work of early-career scientists. Did you recently publish a paper relevant to the complement field? Submit your work and we will promote it!
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4 Feb 2025
PAPER OF THE WEEK (3/4) The authors suggest these findings could be applied as a potential therapeutic strategy for PD by modulating astrocyte-neuron interactions. Read the full paper here! 👇
pubmed.ncbi.nlm.nih.gov/3928…
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4 Feb 2025
PAPER OF THE WEEK (2/4) Overexpression of C3 increased dopaminergic neuron loss in a PD mouse model. The study highlights the role of C3/C3aR signaling between neurons and astrocytes in regulating apoptosis and alpha-synuclein pathology.
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31 Jan 2025
📢January’s ECCO Scientist of the Month is Dr. Lewis Watkins!🎉 Dr. Watkins earned his PhD at Swansea University studying complement in Multiple Sclerosis (MS). He is now a postdoc at Cardiff’s Dementia Research Institute, where he studies the role of complement in dementia (1/4)
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31 Jan 2025
Dr. Watkins would like to share his recent publication (Evans, Watkins, Hawkins et. al., 2023) in which he and other members of Dr. Howell's lab highlight the association between complement activation and grey matter pathology in multiple sclerosis. (4/4) pubmed.ncbi.nlm.nih.gov/3703…
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31 Jan 2025
His favourite complement system component is Factor H and its related proteins. He selected Factor H because whilst it has been identified as dysregulated in dementia, its role in the disease’s aetiology and progression is not fully understood. (3/4)
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31 Jan 2025
Dr. Watkins was introduced to the complement system while working as a research technician in Dr. Owain Howell’s lab. His interest grew when he realized that while complement was well studied in the white matter pathology of MS, its role in grey matter remained unexplored. (2/4)
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