@ProfClark profile picture
Simon J. Clark @ProfClark

Helmut Ecker Endowed Professor of AMD & Co-Founder - Complement Therapeutics. A British Biochemist in Europe 🇬🇧 🇪🇺 @prof-clark.bsky.social

Joined June 2021
  • Tweets 554
  • Following 145
  • Followers 225
54 Photos and videos
Could Ginkgo biloba help target complement dysregulation in dry AMD? New computational evidence identifies potential disease-relevant interactions. #AMD #DryAMD #VisionScience #DrugDiscovery buff.ly/4MPNPCw

Complement-Modulating Mechanisms of Ginkgo biloba Extract in Dry AMD: Insights From Molecular...

Because the blood-retinal barrier limits the efficacy of systemic drugs for retinal diseases, nanomaterial-based ocular delivery systems are gaining attention. However, identifying suitable bioactive...

pubmed.ncbi.nlm.nih.gov
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New study identifies tissue-resident choroidal macrophages as key guardians against AMD, linking their loss to complement-driven retinal degeneration. #AMD #Immunology #Complement #Macrophages #Retina #Ophthalmology #VisionResearch #Aging buff.ly/JThGbjk

Tissue-resident macrophages maintain choroidal homeostasis by complement dependent and independent...

These data demonstrate that long-lived, tissue-resident macrophages are essential for maintaining CC-RPE homeostasis while monocyte-derived macrophages are dispensable in this context. Further,...

pubmed.ncbi.nlm.nih.gov
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A distinct genetic AMD subtype emerges: rare CFH/CFI variants are linked to earlier geographic atrophy and severe drusen burden. #AMD #GeographicAtrophy #Genetics #PrecisionMedicine buff.ly/9Zjotxq

Geographic Atrophy in Patients with Age-Related Macular Degeneration Is Associated with Rare...

The authors have no proprietary or commercial interest in any materials discussed in this article.

pubmed.ncbi.nlm.nih.gov
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I'll be chairing a session at this years ISER meeting in Valencia on 'The role of opsonisation and phagocytosis in ocular immune homeostasis' 23rd to 27th August in Valencia Spain! buff.ly/hGELKaF #Ophthalmology #ISER #retina #AMD #phagocytosis #microglia #macrophage
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Simon J. Clark retweeted
Anna Blom@annamariablom
May 29
Please do not forget to nominate! svarlifescience.com/svar-com…

Svar Complement Excellence Award

Svar Complement Excellence Award – a prize handed out annually to support researchers working on projects within the complement field

svarlifescience.com
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Out new retinal multi-omics study maps 1.48M eQTLs and links rare non-coding variants to AMD & IRDs. #Genomics #Ophthalmology #RNAseq #PrecisionMedicine nature.com/articles/s41467-0…

Paired DNA and RNA sequencing uncovers common and rare variation regulating human retinal gene...

Nature Communications - Here the authors develop a new detailed genetic map of gene expression in the human eye, including both common and rare genetic variation, through the generation of genome...

nature.com
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36-month data show pegcetacoplan slowed subfoveal GA progression by up to 31%, reinforcing complement inhibition in AMD. #Ophthalmology #Retina #AMD buff.ly/GR4RiLN

Efficacy of Continuous Pegcetacoplan Treatment for Subfoveal Geographic Atrophy in Age-Related...

Long-term efficacy of pegcetacoplan in slowing GA progression was demonstrated over 36 months in eyes with subfoveal GA.

pubmed.ncbi.nlm.nih.gov
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I'll be chairing a session at this years ISER meeting in Valencia on 'The role of opsonisation and phagocytosis in ocular immune homeostasis' 23rd to 27th August in Valencia Spain! buff.ly/hGELKaF #Ophthalmology #ISER #retina #AMD #phagocytosis #microglia #macrophage
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Welcome to Katia Ihadadene, who starts her PhD journey through the #Limits2Vision programme, studying the impact of damaged Bruch´s membrane on RPE metabolism, and how underlying genetic risk may alter this response. #VisionScience #Neuroscience #Collaboration #PhDJourney
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New: THN391 — a single antibody that blocks neuroinflammation in Alzheimer's, MS & macular degeneration, without disrupting blood clotting. First-in-class. 🧠👁️ #Neuroscience #Biotech #AlzheimersResearch buff.ly/kvn5Com

Development of a humanized anti-fibrin monoclonal antibody for the treatment of neuroinflammatory...

The online version contains supplementary material available at 10.1186/s12974-025-03650-w.

pubmed.ncbi.nlm.nih.gov
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Aging ECM alone can drive AMD-like pathology—new human Bruch’s membrane model reveals complement activation & lipid buildup. #Aging #AMD #Ophthalmology #ECM #Complement #DrugDiscovery buff.ly/LtiPTkj

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium...

Age-related macular degeneration (AMD), a chronic inflammatory disease, is a major cause of irreversible blindness worldwide. It involves the degeneration of the retinal pigment epithelium (RPE) and...

pubmed.ncbi.nlm.nih.gov
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Study finds AR visual noise may improve sight in AMD, pointing to a novel non-invasive digital therapy for vision loss. #DigitalHealth #MedTech #AMD buff.ly/a3gbxQ5

Visual noise in augmented reality improves vision in age-related macular degeneration - PubMed

Exudative age-related macular degeneration (eAMD) is a degenerative eye disease of the central retina that results in central vision loss, significantly affecting the daily functioning and quality of...

pubmed.ncbi.nlm.nih.gov
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🚀 Ray Therapeutics raises $125M for genetic eye therapies targeting blindness. Strong signal for gene therapy and bold biotech innovation. 👁️✨ #Biotech #GeneTherapy #VisionRestoration buff.ly/BpoemQ4

Ray Therapeutics shines a light on $125M round targeting genetic eye therapy

Gene therapy biotech Ray Therapeutics has announced the closing of a $125 million series B financing to support the company’s vision restoration candidates for patients with retinal degeneration.&n |...

fiercebiotech.com
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Complement Factor H as a Novel Predictive Biomarker for Deep Vein Thrombosis Recurrence: A Prospective Cohort Study buff.ly/t6uUByX

Complement Factor H as a Novel Predictive Biomarker for Deep Vein Thrombosis Recurrence: A Prospe...

Complement Factor H as a Novel Predictive Biomarker for Deep Vein Thrombosis Recurrence: A Prospective Cohort Study

pubmed.ncbi.nlm.nih.gov
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Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular Degeneration buff.ly/GwUDS23

Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular...

Age-related macular degeneration (AMD) is a common, complex disease affecting older individuals that can lead to severe vision loss. It is characterized by early anatomical changes in the retina,...

pubmed.ncbi.nlm.nih.gov
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Human retinal organoid model of disease-relevant photoreceptor cell death amenable to drug screening buff.ly/YVGEGls

Human retinal organoid model of disease-relevant photoreceptor cell death amenable to drug screen...

Dry age-related macular degeneration (AMD) is characterized by the progressive loss of retinal pigment epithelium cells in the macula, leading to photoreceptor degeneration and loss of central...

pubmed.ncbi.nlm.nih.gov
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While one may 'fail' to achieve a primary outcome, the generation of data is never a failure. We can all learn and improve from data reported in these trials. FDA urges clinical trials report results buff.ly/hdvFE4y #clinicaltrials #clinicaltrials.gov #FDA #BioTech

FDA urges clinical trial sponsors to report the results of their studies

An FDA review of records in the U.S. clinical trials database shows that results have not been reported for 30% of clinical studies, the agency said on Monday. To remedy this shortfall, the U.S. | An...

fiercebiotech.com
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Previously overlooked: a novel, potent factor B inhibitor scaffold enters phase 3 for PNH, emerging as a potential rival to Iptacopan and advancing complement-targeted therapeutics. #DrugDiscovery #Complement #PNH #Pharma buff.ly/P8kMHvI

Discovery of (3 R,4 R)-15: An Advanced Factor B Inhibitor Entering Phase 3 for Complement-Mediated...

The alternative pathway (AP) of the complement system plays a critical role in the pathogenesis of various human diseases, including age-related macular degeneration (AMD), paroxysmal nocturnal...

pubmed.ncbi.nlm.nih.gov
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New study reveals FHR-1 as both a driver of complement-mediated injury in IgAN and a novel therapeutic target, reshaping disease biology and treatment strategies. #IgAN #Nephrology #ComplementSystem #Immunology #MedTwitter buff.ly/giVErnc

Dual Role of Factor H-Related Protein 1 in IgA Nephropathy Kidney Injury - PubMed

FHR-1 exacerbates kidney injury in IgAN by accelerating complement activation and inflammation. FHR-1SCR1-2 effectively attenuated FHR-1-induced inflammation, demonstrating promising therapeutic...

pubmed.ncbi.nlm.nih.gov
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Metabolomics genetics reveal a powerful new way to predict AMD risk at population scale—linking systemic biology to eye disease. #AMD #Metabolomics #Genomics #AI #PrecisionMedicine #MedTech #PublicHealth buff.ly/RIz7oqv

Metabolic vulnerability index and MetaboHealth score as risk factors for age-related macular...

The online version contains supplementary material available at 10.1186/s12967-026-07863-2.

pubmed.ncbi.nlm.nih.gov
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