As always, such a pleasure to work with Erin Templeman from the @UniofExeter team, @RAOram, and Lauric Ferrat, as well as an excellent team of collaborators like @cevansmo@catespeake and others who are not on this platform. @IUSweetTweets
Super excited this paper on islet autoantibody positive adults is finally online- we analyzed screening and #T1D progression in 100K adult relatives screened as part of @T1D_TrialNet . Available at: bit.ly/4md4scn
We found important differences exist in screening and progression amongst children and adults. For example:
1. Adults were more likely to screen single Ab positive compared to kids
2. Unlike those were were single Ab positive or met stage 1 T1D criteria, adults with stage 2 T1D at screening progressed at the same rate as children (78% in 5 years)
Thrilled to share our study: Risk associated with single autoantibody shifts after age 10, with men at higher T1D risk. Thanks to @EmKsims, @RAOram, @FerratLauric, and @T1D_TrialNet for their support. Read full press release here: shorturl.at/QojjQ#T1D#DiabetesResearch
Congrats to the global experts recognized as 2024 @WIELDvoice Trailblazers, especially @IUMedSchool Drs. Evans-Molina & DiMeglio and @EliLillyandCo Dr. Gimeno. We're proud and fortunate to have many female leaders in diabetes making an impact in Indiana! womenleadingdiabetes.com/dia…
Great work by @JacobsenLM and @Heba_T1D supporting the idea that metabolic endpoints can give us a quick readout of T1D disease modification. And we know based on @DrPeteTaylor and Colin Dayan's data that these changes have clinical relevance for our patients with T1D!
@T1D_TrialNet identifies earlier trial end points that demonstrate a beneficial treatment effect at 6 months and predict benefit out to 12 months. This could allow for shorter early phase trials or adaptive designs. @ADA_Pubs
Read Here➡️doi.org/10.2337/dc24-0171
Registration is now open to attend the 20th Immunology of Diabetes Society Congress in Bruges, Belgium on Nov 4-8, 2024! Learn more about this year's program, register and submit an abstract by visiting idsbruges2024.com.
#T1DResearch#DiabetesResearch#IDS2024
Do metabolic measures perform similarly for predicting T1D vs. assessing immunotherapy? Not necessarily. However, combined glucose and C-peptide measures were consistent performers for both purposes. Check out at bit.ly/482qeIc ! @T1D_TrialNet@IUSweetTweets
Thrilled to represent @IUDeptPeds and co-lead the newly funded Heartland Children’s Nutrition Collaborative with @ssimsek22 from @PurdueFoodSci. We're extremely grateful for the Ricks Family Foundation's investment in pediatric health and precision nutrition research
Bestill my❤️! Truly bench to bedside work funded by @JDRFResearch showing that β cell drug targets may stabilize insulin secretion in T1D! And I get to work with @rmirmira and @DoctorDiMeglio ! bit.ly/46QZJWz . Thread with TLDR to follow:
(6/6) TLDR: Drugs targeting beta cell health may have potential as agents in a combination regimen to improve insulin secretion in T1D. Next step? Fully powered TADPOL trial in new onset T1D! Find out more at: bit.ly/3tY8QpT